Engineering T cells is a broad description of techniques used to modify a T cells obtained from a patient or healthy donor. T cells are a subset of immune cells responsible for targeting and killing tumor cells. Once harvested from a patient or donor, the T cells can be engineered in a laboratory making them better capable of killing a specific tumor. Examples of adoptive cell therapies using engineered T cells are T cell receptor (TCR)-engineered T cells and chimeric antigen receptor (CAR) T cells.
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The majority of disease-associated genetic variants are thought to have regulatory effects, including disruption of transcription factor (TF) binding and alteration of downstream gene expres...
Date: June 28, 2022 Time: 8:00am (PST), 11:00am (EST), 5:00pm (CEST) Developing safe and effective CAR T cell therapies is a challenging task. That’s why thinking translational early i...
Date: May 31, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEST) Introducing Nanostring’s latest spatial platform, CosMx Spatial Molecular Imager (SMI). Offering high-plex, multiomi...
Date: May 24, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEST) Recent breakthroughs in autologous cellular therapies have generated tremendous excitement for the industry; however, thes...
Date: May 03, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) CRISPR-Cas9 is one of the most commonly leveraged non-viral editing tools to engineer cells for therapeutics applications....
Next-generation sequencing (NGS) has become a foundational tool for both biological research and in-vitro diagnostics, particularly in oncology, immunology, and detection of genetic disorder...
Genetically engineered cellular models are an integral part of the drug discovery process from early discovery through clinical biomanufacturing. The various applications of these cellular m...
Date: December 9, 2021 Time: 8:00am (PDT), 11:00am (EDT) Engineering human regulatory T cells (Tregs) with a chimeric antigen receptor (CAR) targeting donorderived human leukocyte antigen (H...
Date: November 7, 2021 Time: 8:00am (PDT), 11:00am (EDT) Analysis of SARS-CoV-2–specific T cells is important to understand their role during acute disease and in long-term protection...
Date: November 18, 2021 Time: 8:00am (PDT), 11:00am (EDT) Keep ahead in CAR T and CAR NK cell research. We introduce advanced techniques for generating and characterizing engineered immune c...
Date: November 4, 2021 Time: 8:00am (PDT), 11:00am (EDT) The promise of tissue clearing techniques in combination with 3D-immunofluorescence (IF) microscopy is revolutionary. Complex biologi...
Date: September 16, 2021 Time: 7:00am (PDT), 10:00am (EDT) High-dimensional flow cytometry generates a wealth of data. Computational approaches can help to simplify the complexity of large d...
Date: October 12, 2021 Time: 8:00am (PDT), 11:00am (EDT) CRISPR-Cas9 is a nuclease-based genome editing system which has seen exponential growth in adoption with broad applications from basi...
Summary: Cancer neoantigens are highly specific to the tumor, potently immunogenic and can be targeted by both vaccines and engineered cellular therapies. This talk will introduce the defini...
T cells exquisitely discriminate between antigenic and self-peptide ligands presented on major histocompatibility complexes (pMHCs) despite subtle differences in affinities. This aspect of a...