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Gene mutations
Gene mutations describe a change in the DNA sequence that makes up a gene. There are many kinds of gene mutations which have been characterized by scientists. The main categories of mutations are germline mutations, which occur in the gametes (haploid male or female reproductive cells), and somatic mutations, occur in all other cell types. Chromosomal alterations are mutations that change the structure of chromosomes in a variety of ways such as deletion, duplication, insertion, translocation, or inversion of a section of the chromosome. Point mutations include a single nucleotide change within the DNA and these mutations can be classified as silent (the mutation codes for the same amino acid so the change has no effect), missense (the mutation codes for an alternative amino acid), and nonsense (the mutation codes for a premature stop codon). Frameshift mutations occur when the addition or deletion of nucleotide(s) alter the reading frame of the sequence altering all subsequent amino acid coding.
JAN 16, 2024 | 8:00 AM
The clinical interpretation of genetic testing results remains one of the most significant hurdles in effectively applying genomics in modern medicine. Errors in variant interpretation, whet...
DEC 07, 2023 | 8:00 AM
As the vast landscape of genetic oncology continues to expand, the ability to understand and utilize the full potential of this rich data becomes increasingly challenging. As a result, resea...
NOV 16, 2023 | 10:00 AM
Across various stages of the clinical oncology workflow, from panel design to genomic testing and molecular tumor boards, the identification and validation of actionable genomic alterations...
JUL 26, 2023 | 12:15 PM
Genetically modified cell models accelerate the development of safe and effective therapeutics, making them indispensable in the quest for new drugs. Through manipulation of cell line geneti...
JUL 20, 2023 | 8:00 AM
Single-cell ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing, scATAC-seq) is a relatively new and powerful technique that allows researchers to identify open chromatin r...
JUL 11, 2023 | 8:00 AM
Our understanding of cancer mechanisms, genetics and complexities continues to expand rapidly. Without a streamlined, standardized and easy to understand organizational system to keep track...
APR 19, 2023 | 10:00 AM
Date: April 18, 2023 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Whilst a decade ago the prognosis of lung cancer patients has been very disappointing, nowadays a substantial evolutio...
APR 11, 2023 | 8:00 AM
Date: April 11, 2023 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Duchenne muscular dystrophy is caused by mutations in the dystrophin encoding DMD gene that disrupt the reading frame. M...
MAR 30, 2023 | 12:05 PM
In this study, we evaluated the concordance of targeted sequencing results between paired ctDNA and tumor samples from early breast cancers scheduled for curative surgery with or without adj...
MAR 30, 2023 | 12:05 PM
In this study, we evaluated the concordance of targeted sequencing results between paired ctDNA and tumor samples from early breast cancers scheduled for curative surgery with or without adj...
MAR 23, 2023 | 8:00 AM
Date: March 23, 2023 Time: 8:00am (PDT), 11:00am (EDT), 8:00pm (CEST) Across clinical oncology applications, from molecular testing to cancer research the ability to identify potentially act...
MAR 01, 2023 | 8:00 AM
Date: March 01, 2023 Time: 8:00am (PST), 11:00am (EST), 5:00pm (CET) Characterizing metastasis remains key for understanding and eradicating cancer. The study of circulating tumor cells (CTC...
FEB 22, 2023 | 12:00 PM
Have you ever tried to access the genomic profiles of cell lines before using them in your preclinical experiments just to come up empty-handed? Maybe you’ve scoured public databases f...
NOV 01, 2022 | 10:00 AM
Date: November 01, 2022 Time: 10:00am (PDT), 1:00pm (EDT), 6:00pm (CET) Our laboratory developed the Pig-a gene mutation assay as a means to simply and reliably evaluate the potential mutage...
OCT 06, 2022 | 5:00 PM
Genetic biomarkers have become increasingly important for disease prediction, early disease detection and progression, and options for intervention. Tumor biopsies are commonly used as sourc...
OCT 04, 2022 | 7:00 AM
Date: October 04, 2022 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) The ability to derive induced pluripotent stem cells (iPSCs) from differentiated cell types such as fibroblasts, has r...
SEP 27, 2022 | 8:00 AM
Date: September 27, 2022 Time: 8:00am (PDT), 11:00pm (EDT), 5:00pm (CEST) Temperature sensitive (TS) alleles are mutations in essential genes that allow for growth at permissive temperatures...
SEP 22, 2022 | 8:00 AM
Date: September 22, 2022 Time: 8:00am (PDT), 11:00pm (EDT), 5:00pm (CEST) Liquid biopsies are used to identify and track genetic mutationsin cancer patinets, enabling researchers to detect c...
SEP 20, 2022 | 7:00 AM
Date: September 20, 2022 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) Filtration is a critical component of sample preparation and choosing the correct filtration device affects the resu...
SEP 15, 2022 | 9:00 AM
Date: September 15, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEST) Tyrosine kinases, a ubiquitous and diverse family of enzymes, are of considerable clinical interest because they dir...
AUG 17, 2022 | 10:00 PM
Date: August 18, 2022 Time: 3pm AEST | 1pm SGT | 2pm JP/KR Kirsten rat sarcoma viral oncogene homologue (KRAS) is the most frequently mutated oncogene, present in approximately 25% of tumors...
JUL 27, 2022 | 9:00 AM
Date: July 27, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEST) Manufacturing of proteins, mRNA or small molecules requires comprehensive strain engineering approaches to increase yield...
JUN 02, 2022 | 8:00 AM
Date: June 02, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Artificial intelligence (AI) is currently a buzzword across almost all scientific disciplines and has the potential to re...
MAR 30, 2023 | 12:05 PM
In this study, we evaluated the concordance of targeted sequencing results between paired ctDNA and tumor samples from early breast cancers scheduled for curative surgery with or without adj...
MAR 23, 2023 | 8:00 AM
Date: March 23, 2023 Time: 8:00am (PDT), 11:00am (EDT), 8:00pm (CEST) Across clinical oncology applications, from molecular testing to cancer research the ability to identify potentially act...
MAR 01, 2023 | 8:00 AM
Date: March 01, 2023 Time: 8:00am (PST), 11:00am (EST), 5:00pm (CET) Characterizing metastasis remains key for understanding and eradicating cancer. The study of circulating tumor cells (CTC...
FEB 22, 2023 | 12:00 PM
Have you ever tried to access the genomic profiles of cell lines before using them in your preclinical experiments just to come up empty-handed? Maybe you’ve scoured public databases f...