SEP 15, 2022 9:00 AM PDT

Advances and Challenges in Targeting Kinases in Cancer Therapeutics

Sponsored by: BPS Bioscience
Speakers

Abstract
Date:  September 15, 2022
Time: 9:00am (PDT),  12:00pm (EDT), 6:00pm (CEST)
 
Tyrosine kinases, a ubiquitous and diverse family of enzymes, are of considerable clinical interest because they directly contribute to the development of cancer. A growing number of tyrosine kinase inhibitors are in clinical use with many more in development.
 
Bruton's tyrosine kinase (BTK) is a receptor-type tyrosine kinase critical for B cell maturation. It is encoded by the BTK gene, located on the X chromosome. Mutations in BTK cause a primary immunodeficiency phenotype linked to the failure of pre-B cells to mature (a disease termed Bruton's agammaglobulinemia). Due to its control of B cell proliferation and survival, aberrant activity of BTK leads to B cell tumorigenicity. Several BTK inhibitors are used for the clinical treatment of various forms of lymphoma, including chronic lymphocytic leukemia (CLL). Covalent BTK inhibitors (BTKis) have led to an unprecedented improvement in CLL outcomes. However, disease progression on covalent BTKis, driven by histologic transformation or selective expansion of BTK-mutated CLL clones, remains a major challenge.
 
Dr. Aishath's talk will focus on:
- Targeting BTK in CLL
- Comparative analysis of covalent and non-covalent BTK inhibitors
- Resistance mechanisms to BTK inhibitors
 
Dr. Baron will speak about:
- Tools to study kinases
- CRISPR/Cas9 Human Kinase Knockout Lentivirus Library
- Unique assays to study JAK inhibitors
- Off-the-shelf cell-based reporter systems
 
 
 
Webinars will be available for unlimited on-demand viewing after live event.
 

Show Resources
You May Also Like
NOV 16, 2022 7:00 PM PST
C.E. CREDITS
NOV 16, 2022 7:00 PM PST
Date: November 16, 2022 Time: 2:00pm (AEST) Date: November 17, 2022 7:00pm (PST), 10:00pm (EST), 4:00am (CET) The growth in FDA-approved cell and gene therapy products for the treatment of d...
MAY 17, 2022 9:00 AM PDT
MAY 17, 2022 9:00 AM PDT
Date: May 17, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 8:00pm (CEST) Gene therapeutics have great potential to treat many severe diseases in an unprecedented, targeted manner. The biopharmace...
NOV 09, 2022 8:00 AM PST
NOV 09, 2022 8:00 AM PST
Date: November 09, 2022 Time: 8:00am (PST), 11:00am (EST), 5:00pm (CET) The field of cell and gene therapy is rapidly growing. In particular, the use of lentiviruses in CAR-T applications is...
SEP 13, 2022 8:00 AM PDT
SEP 13, 2022 8:00 AM PDT
Date: September 13, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Preparedness against pandemic diseases demands rapid-response vaccine technology and ready-to-use analytical methods...
AUG 16, 2022 11:00 AM PDT
AUG 16, 2022 11:00 AM PDT
Date: August 16, 2022 Time: 11:00am (PDT), 2:00pm (EDT), 8:00pm (CEST) Understanding genomic variation in the context of cancer is paramount to identifying disease drivers and informing pers...
SEP 22, 2022 9:00 AM PDT
SEP 22, 2022 9:00 AM PDT
Date: September 22, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEST) Optimizing platforms for surgical specimen collection and deep human phenotyping was used to enhance protein biomarke...
Loading Comments...
Show Resources