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    In vitro biology

    In vitro biology is the study of cells, tissues, and organs from various organisms including plants, animals, and humans. When performed in vitro, these studies are performed outside of the living organism, in a laboratory.

    Webinars

    • SEP 30, 2020 | 12:00 PM
      Efficient Generation of Gene-edited Mouse Models and Cell Lines Using Synthetic sgRNA
      Efficient Generation of Gene-edited Mouse Models and Cell Lines...
      The CRISPR/Cas genome editing system has revolutionized nearly every aspect of the life science industry. Until recently, the most used formats for this technology have been plasmids, mRNA,...
      Speaker: Gurpreet Balrey, PhD , Peter Romanienko, PhD
      Presented at: CRISPR Virtual Event Series 2020
      Sponsored By: MilliporeSigma
      4
      SEP 30, 2020 | 10:30 AM
      Straightforward CRISPR knockout: Leveraging predesigned synthetic sgRNAs for highly functional and specific gene knockout
      Straightforward CRISPR knockout: Leveraging predesigned synthetic...
      CRISPR-based genome editing has accelerated biological research and holds great potential for studying and treating human diseases. The CRISPR-Cas9 system requires a Cas9 nuclease and a guid...
      Speaker: James Goldmeyer, PhD
      Presented at: CRISPR Virtual Event Series 2020
      Sponsored By: Horizon Discovery
      3 1
      SEP 23, 2020 | 3:00 PM
      Beyond the Culture Flask: How Membrane- and Microfluidic-based Platforms can create more Physiologically Relevant Tissue Culture Systems
      Beyond the Culture Flask: How Membrane- and Microfluidic-based...
      For more than a century, breakthroughs in biological sciences have relied on the ability to study cells outside of respective organisms. While majority of cell culturing is still performed u...
      Speaker: Jun Park, PhD
      Presented at: Cell Biology Virtual Event Series 2020
      Sponsored By: MilliporeSigma
      1
      SEP 23, 2020 | 12:00 PM
      Keynote Presentation: Sorting out the mechanisms of endocytic recycling
      Keynote Presentation: Sorting out the mechanisms of endocytic...
      Extracellular ligands bind to receptors on the cell surface leading to receptor internalization. Once internalized into small vesicles, the vesicles fuse with an organelle known as the sorti...
      Speaker: Steve Caplan, PhD
      Presented at: Cell Biology Virtual Event Series 2020
      1
      SEP 23, 2020 | 12:00 AM
      The role of Nox-derived Reactive Oxygen Species in Axonal Growth and Guidance
      The role of Nox-derived Reactive Oxygen Species in Axonal Growth...
      Reactive oxygen species (ROS) are well-known for their detrimental effects leading to oxidative stress, cell death, aging, and degenerative disorders. However, there is increasing evidence t...
      Speaker: Daniel M. Suter, PhD
      Presented at: Cell Biology Virtual Event Series 2020
      2
      SEP 23, 2020 | 12:00 AM
      Extracellular Vesicles and Chronic Kidney Disease
      Extracellular Vesicles and Chronic Kidney Disease
      Chronic kidney disease (CKD) is a major public health threat, affecting 11-15% of the U.S. population alone. Currently, there are no effective therapies to cure CKD. Drug therapies are not p...
      Speaker: Sargis Sedrakyan, PhD
      Presented at: Cell Biology Virtual Event Series 2020
      1
      SEP 17, 2020 | 12:00 PM
      Antibody therapy against SARS-CoV-2: A Global Collaboration
      Antibody therapy against SARS-CoV-2: A Global Collaboration
      Therapeutic antibody can provide key protection or lifesaving treatment for those who haven't been or can’t be vaccinated, or when vaccines don’t “take". We galvan...
      Speaker: Erica Ollmann Saphire, PhD
      Presented at: Coronavirus Series
      2
      SEP 16, 2020 | 12:15 PM
      High-resolution HCA-based phenotypic profiling of tumor spheroids and organoids
      High-resolution HCA-based phenotypic profiling of tumor spheroids...
      Image-based high-content screening (HCS) involving cancer cell lines grown in conventional two-dimensional (2D) cell culture, has provided a cornerstone assay for searching new agents to tre...
      Speaker: Meritxell B. Cutrona, PhD
      Presented at: 7th Annual Conference: SBI2 High Content
      2
      SEP 10, 2020 | 12:00 AM
      Visualizing viral replication of oncogenic human herpesviruses
      Visualizing viral replication of oncogenic human herpesviruses
      Viruses are the causative agents of approximately 12% of human cancers. The most recently discovered herpesvirus, Kaposi’s sarcoma herpesvirus (KSHV) is known to cause three human canc...
      Speaker: Lindsey M. Costantini, PhD
      Presented at: Microbiology Week Virtual Event Series 2020
      1
      SEP 09, 2020 | 12:00 AM
      A New KIR Haplotype MSA Empowers Two New Interpretation Algorithms
      A New KIR Haplotype MSA Empowers Two New Interpretation Algorithms
      Human chromosome 19q13.4 contains genes encoding killer-cell immunoglobulin-like receptors (KIR). The region has certain properties such as single nucleotide variation, structural variation,...
      Speaker: David Roe
      Presented at: Microbiology Week Virtual Event Series 2020
      1
      SEP 08, 2020 | 11:00 PM
      Development of Respiratory Syncytial Virus and Universal Influenza Virus Vaccines Conformationally Stabilized by Targeted Dityrosine Crosslinking
      Development of Respiratory Syncytial Virus and Universal Influenza...
      While viral fusion proteins are highly desirable for subunit vaccine generation, their inherent metastable nature complicates implementation and development. We have harnessed the structural...
      Speaker: Mark A. Yondola, PhD
      Presented at: Microbiology Week Virtual Event Series 2020
      1
      AUG 26, 2020 | 8:00 AM
      Bio-Layer Interferometry as a strategic platform to validate covalent "proximity inducing" small molecules with synthetic tumor Immunotherapeutic applications
      Bio-Layer Interferometry as a strategic platform to validate covalent...
      DATE: August 26, 2020 TIME: 8:00 am PDT The host immune "recognition" of cancer forms the basis of modern tumor immmunotherapy, a highly targeted treatment option with the demonstr...
      Speaker: Anthony Rullo , Nilshad Salim, Ph.D.
      Sponsored By: Sartorius
      13
      AUG 06, 2020 | 10:00 AM
      Part IX: Unraveling the interplay between transcription and RNA folding
      Part IX: Unraveling the interplay between transcription and RNA...
      RNA mediates essential biological processes in all organisms. These functions include catalysis of crucial biochemical reactions such as peptidyl transfer during translation and transesterif...
      Speaker: Eric Strobel, PhD
      Presented at: 2020 Beckman Symposium
      1
      JUL 29, 2020 | 9:00 AM
      Impedance-based assay to evaluate potency of immunotherapy products
      Impedance-based assay to evaluate potency of immunotherapy products
      Advances in genetic engineering have improved specificity, safety and potency of T-cell receptor (TCR) and Chimeric Antigen Receptor (CAR-T) based therapies for solid and non-solid tumours....
      Speaker: Juan Miguel Sanchez Nieto, PhD
      Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
      1
      JUL 01, 2020 | 8:00 AM
      Applied Biosystems™ TaqPath™ COVID-19 Combo Kit*: A highly sensitive, specific, and robust real-time PCR test
      Applied Biosystems™ TaqPath™ COVID-19 Combo Kit*: A highly sensitive,...
      DATE: July 1, 2020 TIME: 8:00 am PDT, 11:00 am EDT In late 2019, researchers identified the SARS-CoV-2 pathogen as the virus responsible for COVID-19. The virus spread rapidly throughout the...
      Speaker: Lauren Mikulski , Vijay Singh, PhD , Andrew Brooks, Ph.D.
      Sponsored By: Thermo Fisher Scientific
      25 2
      JUN 30, 2020 | 9:00 AM
      Quality Control for the Pharmaceutical Industry; Stage 3, Continued Verification, in the Lifecycle of Analytical Procedures
      Quality Control for the Pharmaceutical Industry; Stage 3, Continued...
      DATE: June 30, 2020 TIME: 9:00am PDT, 12:00pm EDT QC laboratories perform a critical role in demonstrating pharmaceutical products are consistently manufactured, safe, potent, and pure. At t...
      Speaker: Jane Weitzel
      Sponsored By: Sartorius
      17 1
      JUN 18, 2020 | 9:00 AM
      Unveiling the role of T cell dysfunction in the development and progression of glioblastoma
      Unveiling the role of T cell dysfunction in the development and...
      DATE: June 18, 2020 TIME: 9:00am PDT, 12:00pm EDT Despite the success of immunotherapy against several malignancies including melanoma and lung adenocarcinoma, glioblastoma remains the excep...
      Speaker: Felipe Galvez Cancino, Ph.D.
      Sponsored By: Thermo Fisher Scientific/Gibco
      18 2
      JUN 17, 2020 | 4:30 PM
      Critical raw material for mRNA-based vaccine development
      Critical raw material for mRNA-based vaccine development
      Accelerated development of mRNA-based vaccine has necessitated the transformation of standard, research grade in vitro transcription reagents into raw material specifically designed and manu...
      Speaker: Andrius Kočevas
      Presented at: Coronavirus Series
      Sponsored By: Thermo Fisher Scientific
      1
      JUN 17, 2020 | 1:30 PM
      Insights into the Pathogenesis of COVID-19 as Revealed by Spatial Biology
      Insights into the Pathogenesis of COVID-19 as Revealed by Spatial...
      Understanding the complex interplay between a pathogen and the host response is important to developing effective vaccines and therapeutics. The nCounter® Analysis System and GeoMx®...
      Speaker: Joseph M. Beechem, PhD , Christopher E. Mason, PhD , Robert Schwartz, PhD
      Presented at: Coronavirus Series
      Sponsored By: NanoString Technologies
      9
      MAY 19, 2020 | 11:15 AM
      A Multi-omic Single Cell and Spatial Atlas of Breast Cancer Reveals Stromal Suppression of Anti-Cancer Immunity
      A Multi-omic Single Cell and Spatial Atlas of Breast Cancer Reveals...
      We applied CITE-Seq to measure >150 cell surface immune markers and checkpoint proteins simultaneous to RNA-Sequencing. We resolve the tumour-immune milieu with high precision and reveal...
      Speaker: Alex Swarbrick, PhD
      Presented at: Advancing Science - A Virtual Oncology Conference
      4
      MAY 19, 2020 | 8:00 AM
      Looking Beyond PCR: Isothermal Amplification
      Looking Beyond PCR: Isothermal Amplification
      DATE: May 19, 2020 TIME: 8:00am PT, 11:00am ET Limited sample material resulting in insufficient DNA input is a common hurdle for downstream analysis. This problem can be solved using a vari...
      Speaker: Agne Alminaite, PhD , Remigijus Skirgaila, Ph.D.
      Sponsored By: Thermo Fisher Scientific
      71 5
      MAY 14, 2020 | 6:00 AM
      Embracing biological variation to improve reproducibility and reduce animal use
      Embracing biological variation to improve reproducibility and...
      In the course of the so-called reproducibility crisis, various sources of poor reproducibility of animal research have been identified, including a lack of scientific rigor, low statistical...
      Speaker: Hanno Würbel
      Presented at: Laboratory Animal Sciences Virtual Event Series 2020
      3 1
      MAY 14, 2020 | 12:00 AM
      Data Collection as Environmental Enrichment: Automated Behavioral Measurement in Voluntary Home Cage Operant Tasks
      Data Collection as Environmental Enrichment: Automated Behavioral...
      Biomedical research suffers from a translation gap, where most treatments that seem effective when tested on animals turn out not to work in human patients. This is likely due in large part...
      Speaker: Jamie Ahloy Dallaire, MSc, PhD
      Presented at: Laboratory Animal Sciences Virtual Event Series 2020
      0
      MAY 13, 2020 | 9:00 AM
      Get Closer to the Truth: STELLARIS - Confocal Re-Imagined
      Get Closer to the Truth: STELLARIS - Confocal Re-Imagined
      DATE: May 13, 2020 TIME: 9:00am PT, 12:00pm ET STELLARIS. Confocal re-imagined. In microscopy, our mission is to empower you to drive progress in science. To get you closer to the truth, we...
      Speaker: Petra Haas, Ph.D. , Julia Roberti, Ph.D.
      Sponsored By: Leica Microsystems
      14
    SEP 30, 2020 | 12:00 PM
    Efficient Generation of Gene-edited Mouse Models and Cell Lines Using Synthetic sgRNA
    Efficient Generation of Gene-edited Mouse Models and Cell Lines...
    The CRISPR/Cas genome editing system has revolutionized nearly every aspect of the life science industry. Until recently, the most used formats for this technology have been plasmids, mRNA,...
    Speaker: Gurpreet Balrey, PhD , Peter Romanienko, PhD
    Presented at: CRISPR Virtual Event Series 2020
    Sponsored By: MilliporeSigma
    4
    SEP 30, 2020 | 10:30 AM
    Straightforward CRISPR knockout: Leveraging predesigned synthetic sgRNAs for highly functional and specific gene knockout
    Straightforward CRISPR knockout: Leveraging predesigned synthetic...
    CRISPR-based genome editing has accelerated biological research and holds great potential for studying and treating human diseases. The CRISPR-Cas9 system requires a Cas9 nuclease and a guid...
    Speaker: James Goldmeyer, PhD
    Presented at: CRISPR Virtual Event Series 2020
    Sponsored By: Horizon Discovery
    3 1
    SEP 23, 2020 | 3:00 PM
    Beyond the Culture Flask: How Membrane- and Microfluidic-based Platforms can create more Physiologically Relevant Tissue Culture Systems
    Beyond the Culture Flask: How Membrane- and Microfluidic-based...
    For more than a century, breakthroughs in biological sciences have relied on the ability to study cells outside of respective organisms. While majority of cell culturing is still performed u...
    Speaker: Jun Park, PhD
    Presented at: Cell Biology Virtual Event Series 2020
    Sponsored By: MilliporeSigma
    1
    SEP 23, 2020 | 12:00 PM
    Keynote Presentation: Sorting out the mechanisms of endocytic recycling
    Keynote Presentation: Sorting out the mechanisms of endocytic...
    Extracellular ligands bind to receptors on the cell surface leading to receptor internalization. Once internalized into small vesicles, the vesicles fuse with an organelle known as the sorti...
    Speaker: Steve Caplan, PhD
    Presented at: Cell Biology Virtual Event Series 2020
    1
    SEP 23, 2020 | 12:00 AM
    The role of Nox-derived Reactive Oxygen Species in Axonal Growth and Guidance
    The role of Nox-derived Reactive Oxygen Species in Axonal Growth...
    Reactive oxygen species (ROS) are well-known for their detrimental effects leading to oxidative stress, cell death, aging, and degenerative disorders. However, there is increasing evidence t...
    Speaker: Daniel M. Suter, PhD
    Presented at: Cell Biology Virtual Event Series 2020
    2
     
     
  • SEP 23, 2020 | 12:00 AM
    Extracellular Vesicles and Chronic Kidney Disease
    Extracellular Vesicles and Chronic Kidney Disease
    Chronic kidney disease (CKD) is a major public health threat, affecting 11-15% of the U.S. population alone. Currently, there are no effective therapies to cure CKD. Drug therapies are not p...
    Speaker: Sargis Sedrakyan, PhD
    Presented at: Cell Biology Virtual Event Series 2020
    1
    SEP 17, 2020 | 12:00 PM
    Antibody therapy against SARS-CoV-2: A Global Collaboration
    Antibody therapy against SARS-CoV-2: A Global Collaboration
    Therapeutic antibody can provide key protection or lifesaving treatment for those who haven't been or can’t be vaccinated, or when vaccines don’t “take". We galvan...
    Speaker: Erica Ollmann Saphire, PhD
    Presented at: Coronavirus Series
    2
    SEP 16, 2020 | 12:15 PM
    High-resolution HCA-based phenotypic profiling of tumor spheroids and organoids
    High-resolution HCA-based phenotypic profiling of tumor spheroids...
    Image-based high-content screening (HCS) involving cancer cell lines grown in conventional two-dimensional (2D) cell culture, has provided a cornerstone assay for searching new agents to tre...
    Speaker: Meritxell B. Cutrona, PhD
    Presented at: 7th Annual Conference: SBI2 High Content
    2
    SEP 10, 2020 | 12:00 AM
    Visualizing viral replication of oncogenic human herpesviruses
    Visualizing viral replication of oncogenic human herpesviruses
    Viruses are the causative agents of approximately 12% of human cancers. The most recently discovered herpesvirus, Kaposi’s sarcoma herpesvirus (KSHV) is known to cause three human canc...
    Speaker: Lindsey M. Costantini, PhD
    Presented at: Microbiology Week Virtual Event Series 2020
    1
    SEP 09, 2020 | 12:00 AM
    A New KIR Haplotype MSA Empowers Two New Interpretation Algorithms
    A New KIR Haplotype MSA Empowers Two New Interpretation Algorithms
    Human chromosome 19q13.4 contains genes encoding killer-cell immunoglobulin-like receptors (KIR). The region has certain properties such as single nucleotide variation, structural variation,...
    Speaker: David Roe
    Presented at: Microbiology Week Virtual Event Series 2020
    1
     
     
  • SEP 08, 2020 | 11:00 PM
    Development of Respiratory Syncytial Virus and Universal Influenza Virus Vaccines Conformationally Stabilized by Targeted Dityrosine Crosslinking
    Development of Respiratory Syncytial Virus and Universal Influenza...
    While viral fusion proteins are highly desirable for subunit vaccine generation, their inherent metastable nature complicates implementation and development. We have harnessed the structural...
    Speaker: Mark A. Yondola, PhD
    Presented at: Microbiology Week Virtual Event Series 2020
    1
    AUG 26, 2020 | 8:00 AM
    Bio-Layer Interferometry as a strategic platform to validate covalent "proximity inducing" small molecules with synthetic tumor Immunotherapeutic applications
    Bio-Layer Interferometry as a strategic platform to validate covalent...
    DATE: August 26, 2020 TIME: 8:00 am PDT The host immune "recognition" of cancer forms the basis of modern tumor immmunotherapy, a highly targeted treatment option with the demonstr...
    Speaker: Anthony Rullo , Nilshad Salim, Ph.D.
    Sponsored By: Sartorius
    13
    AUG 06, 2020 | 10:00 AM
    Part IX: Unraveling the interplay between transcription and RNA folding
    Part IX: Unraveling the interplay between transcription and RNA...
    RNA mediates essential biological processes in all organisms. These functions include catalysis of crucial biochemical reactions such as peptidyl transfer during translation and transesterif...
    Speaker: Eric Strobel, PhD
    Presented at: 2020 Beckman Symposium
    1
    JUL 29, 2020 | 9:00 AM
    Impedance-based assay to evaluate potency of immunotherapy products
    Impedance-based assay to evaluate potency of immunotherapy products
    Advances in genetic engineering have improved specificity, safety and potency of T-cell receptor (TCR) and Chimeric Antigen Receptor (CAR-T) based therapies for solid and non-solid tumours....
    Speaker: Juan Miguel Sanchez Nieto, PhD
    Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
    1
    JUL 01, 2020 | 8:00 AM
    Applied Biosystems™ TaqPath™ COVID-19 Combo Kit*: A highly sensitive, specific, and robust real-time PCR test
    Applied Biosystems™ TaqPath™ COVID-19 Combo Kit*: A highly sensitive,...
    DATE: July 1, 2020 TIME: 8:00 am PDT, 11:00 am EDT In late 2019, researchers identified the SARS-CoV-2 pathogen as the virus responsible for COVID-19. The virus spread rapidly throughout the...
    Speaker: Lauren Mikulski , Vijay Singh, PhD , Andrew Brooks, Ph.D.
    Sponsored By: Thermo Fisher Scientific
    25 2
     
     
  • JUN 30, 2020 | 9:00 AM
    Quality Control for the Pharmaceutical Industry; Stage 3, Continued Verification, in the Lifecycle of Analytical Procedures
    Quality Control for the Pharmaceutical Industry; Stage 3, Continued...
    DATE: June 30, 2020 TIME: 9:00am PDT, 12:00pm EDT QC laboratories perform a critical role in demonstrating pharmaceutical products are consistently manufactured, safe, potent, and pure. At t...
    Speaker: Jane Weitzel
    Sponsored By: Sartorius
    17 1
    JUN 18, 2020 | 9:00 AM
    Unveiling the role of T cell dysfunction in the development and progression of glioblastoma
    Unveiling the role of T cell dysfunction in the development and...
    DATE: June 18, 2020 TIME: 9:00am PDT, 12:00pm EDT Despite the success of immunotherapy against several malignancies including melanoma and lung adenocarcinoma, glioblastoma remains the excep...
    Speaker: Felipe Galvez Cancino, Ph.D.
    Sponsored By: Thermo Fisher Scientific/Gibco
    18 2
    JUN 17, 2020 | 4:30 PM
    Critical raw material for mRNA-based vaccine development
    Critical raw material for mRNA-based vaccine development
    Accelerated development of mRNA-based vaccine has necessitated the transformation of standard, research grade in vitro transcription reagents into raw material specifically designed and manu...
    Speaker: Andrius Kočevas
    Presented at: Coronavirus Series
    Sponsored By: Thermo Fisher Scientific
    1
    JUN 17, 2020 | 1:30 PM
    Insights into the Pathogenesis of COVID-19 as Revealed by Spatial Biology
    Insights into the Pathogenesis of COVID-19 as Revealed by Spatial...
    Understanding the complex interplay between a pathogen and the host response is important to developing effective vaccines and therapeutics. The nCounter® Analysis System and GeoMx®...
    Speaker: Joseph M. Beechem, PhD , Christopher E. Mason, PhD , Robert Schwartz, PhD
    Presented at: Coronavirus Series
    Sponsored By: NanoString Technologies
    9
    MAY 19, 2020 | 11:15 AM
    A Multi-omic Single Cell and Spatial Atlas of Breast Cancer Reveals Stromal Suppression of Anti-Cancer Immunity
    A Multi-omic Single Cell and Spatial Atlas of Breast Cancer Reveals...
    We applied CITE-Seq to measure >150 cell surface immune markers and checkpoint proteins simultaneous to RNA-Sequencing. We resolve the tumour-immune milieu with high precision and reveal...
    Speaker: Alex Swarbrick, PhD
    Presented at: Advancing Science - A Virtual Oncology Conference
    4
     
     
  • MAY 19, 2020 | 8:00 AM
    Looking Beyond PCR: Isothermal Amplification
    Looking Beyond PCR: Isothermal Amplification
    DATE: May 19, 2020 TIME: 8:00am PT, 11:00am ET Limited sample material resulting in insufficient DNA input is a common hurdle for downstream analysis. This problem can be solved using a vari...
    Speaker: Agne Alminaite, PhD , Remigijus Skirgaila, Ph.D.
    Sponsored By: Thermo Fisher Scientific
    71 5
    MAY 14, 2020 | 6:00 AM
    Embracing biological variation to improve reproducibility and reduce animal use
    Embracing biological variation to improve reproducibility and...
    In the course of the so-called reproducibility crisis, various sources of poor reproducibility of animal research have been identified, including a lack of scientific rigor, low statistical...
    Speaker: Hanno Würbel
    Presented at: Laboratory Animal Sciences Virtual Event Series 2020
    3 1
    MAY 14, 2020 | 12:00 AM
    Data Collection as Environmental Enrichment: Automated Behavioral Measurement in Voluntary Home Cage Operant Tasks
    Data Collection as Environmental Enrichment: Automated Behavioral...
    Biomedical research suffers from a translation gap, where most treatments that seem effective when tested on animals turn out not to work in human patients. This is likely due in large part...
    Speaker: Jamie Ahloy Dallaire, MSc, PhD
    Presented at: Laboratory Animal Sciences Virtual Event Series 2020
    0
    MAY 13, 2020 | 9:00 AM
    Get Closer to the Truth: STELLARIS - Confocal Re-Imagined
    Get Closer to the Truth: STELLARIS - Confocal Re-Imagined
    DATE: May 13, 2020 TIME: 9:00am PT, 12:00pm ET STELLARIS. Confocal re-imagined. In microscopy, our mission is to empower you to drive progress in science. To get you closer to the truth, we...
    Speaker: Petra Haas, Ph.D. , Julia Roberti, Ph.D.
    Sponsored By: Leica Microsystems
    14
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