Bio-Layer Interferometry as a strategic platform to validate covalent "proximity inducing" small molecules with synthetic tumor Immunotherapeutic applications

Professor Rullo obtained scientific training and experience in several aspects of organic synthesis and carbohydrate chemistry, physical biochemistry, and immunology. After obtaining an undergraduate in Biochemistry from McMaster University, he engaged in structural carbohydrate chemistry and polysaccharide vaccine development with Dr. Mario A. Monteiro during his master's studies. As a doctoral student under the supervision of Dr. Mark Nitz at the University of Toronto, he developed fluorescent chemical probes of complex glycosaminoglycan binding interactions, in addition to new bio-orthogonal affinity labelling strategies. Dr. Rullo conducted his postdoctoral research in Dr. David A. Spiegel's laboratory at Yale University working to develop new small molecule based anti-cancer immunotherapeutic approaches. His research yielded the discovery of first in class antibody recruiting molecules capable of targeting highly metastatic cancers in vivo. His laboratory is currently initiating three platforms engaging both basic molecular science and translational cancer therapeutic research on the interface of chemistry and tumor immunology. These platforms are focused on the design of "proximity inducing" covalent and multivalent chemical tools to interrogate immune activation mechanisms, and the development of new synthetic molecule based tumor immunotherapeutic targeting strategies.

The Rullo Lab https://www.rullolab.com/
Dr Rullo's Pubmed publications https://pubmed.ncbi.nlm.nih.gov/?term=Anthony+Rullo
Additional publications https://pubmed.ncbi.nlm.nih.gov/?term=Rullo+A;+Rullo+AF

Nilshad Salim is a Marketing Applications Manager at ForteBio, and has been with the company since 2016. Nilshad is responsible for identifying, developing, and validating emerging applications and workflow solutions that enhance our label-free portfolio. His work focuses on several vertical markets including antibody discovery, cell line development, and biomolecular interaction analysis. Prior to joining ForteBio, he held postdoctoral research roles in the areas of virology and cancer biology at Indiana University School of Medicine, and the University of Kansas Medical Center. Nilshad obtained his Ph.D. in biochemistry from Wayne State University in 2011.