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Nucleosomes
A nucleosome is the basic structural unit of DNA packaging in eukaryotes. The structure of a nucleosome consists of a segment of DNA wound around eight histone proteins, and looks like a thread wrapped around a spool. It's a fundamental subunit of chromatin.
APR 20, 2021 | 12:00 AM
The complete assembly of each human chromosome is essential for understanding human biology and evolution. Using complementary long-read sequencing technologies, we complete the first linear...
APR 29, 2020 | 6:00 AM
Histone post-translational modifications (PTMs) play pivotal roles in chromatin dynamics and function, with alterations in the healthy profile associated with diverse human pathologies. The...
MAY 08, 2019 | 6:00 AM
C.E. CREDITS
Genetic drivers of cancer can be dysregulated through epigenetic modifications of DNA. Although the critical role of DNA 5-methylcytosine (5mC) in the regulation of transcription is recognize...
OCT 31, 2018 | 8:00 AM
DATE: October 31, 2018TIME: 8:00AM PDTChromatin immunoprecipitation (ChIP) is a technique researchers employ to obtain a snapshot of protein-DNA interactions in the cell. ChI...
MAY 30, 2018 | 10:30 AM
NSD2 catalyzes the mono- and di-methylation of the e-amine of lysine 36 from histone H3, utilizing the methyl donor S-adenosyl-L-methionine. Increased catalytic activity of NSD2, either by ov...
OCT 12, 2017 | 6:00 AM
We developed two computational methods, CARE and TIDE, to predict response and resistance to targeted therapies and immunotherapies. CARE infers gene signatures of targeted therapy response b...
JAN 17, 2017 | 8:00 AM
Bivalent domains are thought to be controversial, yet crucial, regulatory hubs in the differentiation of stem cells. Listen in as Dr Philipp Voigt of the Wellcome Trust Centre for...
NOV 23, 2016 | 8:00 AM
DATE: November 23rd, 2016TIME: 8:00AM PT, 11:00AM ETThe structure of chromatin is critical for many aspects of cellular physiology and is considered to be the primary medium to store ep...