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JAN 17, 2017 8:00 AM PST

Regulation of Bivalent Domains by Histone Modifications

Speaker
  • Wellcome Trust Sir Henry Dale career development Fellow, Wellcome Trust Centre for Cell Biology at the University of Edinburgh
    Biography
      Dr Philipp Voigt received both his undergraduate and PhD degrees in Biochemistry from Freie Universität Berlin, Germany. For his thesis work, Philipp studied phosphoinositide 3-kinase gamma, a lipid and protein kinase controlling inflammatory processes.

      After receiving his PhD in 2007, he switched fields by joining the laboratory of Dr. Danny Reinberg at NYU School of Medicine, where he worked on the mechanisms of gene repression by Polycomb group proteins and nucleosomal asymmetry between 2008-2014. In late 2014, Philipp joined the Wellcome Trust Centre for Cell Biology at the University of Edinburgh as a Wellcome Trust Sir Henry Dale career development Fellow.

      Work in his lab focuses on understanding how the Polycomb and Trithorax systems of histone modifiers interact to regulate gene expression in stem cells, especially in the context of bivalent domains.

    Abstract

    Bivalent domains are thought to be controversial, yet crucial,  regulatory hubs in the differentiation of stem cells. Listen in as  Dr Philipp Voigt of the Wellcome Trust Centre for Cell Biology at the University of Edinburgh as he reviews the concepts of bivalent domains, the impact of nucleosomal asymmetry and bivalency, and current views on the functions and mechanisms of bivalent domains.


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