Phosphoinositide 3-kinase (PI3K) describes a family of enzymes required for a variety of cellular functions.  PI3K pathways are important for processes, including cellular growth, proliferation, differentiation, and intracellular trafficking. 
            
            
            
         
     
    
        
                    
                                    
                
         
                
                    
                                        
                        
                    
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        Learning Objectives: 1. Understand how the outcome of PD-1 blockade is a summation of increased Teffector activity and increased Treg suppressive activity 2. Explain how PD-1 blockade leads...
     
 
 
                                    
                                                                    
                                    
                                        
    
    
    
        Activating mutations in PIK3CA are frequent in human breast cancer, and phosphoinositide 3-kinase alpha (PI3Kα) inhibitors have been approved for therapy. To characterize determinants...
    
    
            
     
                                     
                                    
                                                                    
                                    
                                        
    
    
    
        Combinatorial inhibition of effector and feedback pathways is a promising treatment strategy for KRAS mutant cancers. However, the particular pathways that should be targeted to optimize the...
    
    
            
     
                                     
                                    
                                                                    
                                    
                                        
    
    
    
        On measuring photons and ions: Impact on panel design, signal detection and data quality 10:30–11:00 am PDT Presented By: Tim Bushnell, PhD, MBA Monitoring immunotherapy with a mass cy...
    
    
            
     
                                     
                                    
                                                                    
                                    
                                        
    
    
    
        With over 200 validated antibodies and the option to add custom antibodies, the GeoMx DSP protein portfolio offers options to fit a wide range of spatial profiling application needs. NanoStr...