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    Scale-down

    In pharmaceutical sciences, a scale-down refers to processes that support manufacturing regulation. When a parameter needed for pharmaceutical development falls out of range, a scale-down is implemented to keep production on course. Good controls indicating when a point of failure may occur are needed to indicate when a scale-down should be implemented.

    Webinars

    • OCT 24, 2023 | 10:00 AM
      An epic advance in epigenomics: Automated CUT&RUN enables chromatin profiling for scaled research & drug discovery applications
      An epic advance in epigenomics: Automated CUT&RUN enables chromatin...
      Dynamic changes in chromatin drive gene expression programs during cellular development and contribute to pathological changes underlying disease. To date, efforts to characterize chromatin...
      Speaker: Andrea Johnstone, Ph.D. , Lori Euler
      Sponsored By: Beckman Coulter Life Sciences
      30
      JUN 06, 2023 | 9:00 AM
      Time-resolved electron microscopy: synaptic ultrastructure millisecond by millisecond with high-pressure freezing
      Time-resolved electron microscopy: synaptic ultrastructure millisecond...
      Transmission electron microscopy reveals the architecture of cells at nanometer resolution, but chemical fixation severely warps their native structure. The true ultrastructure of cells can...
      Speaker: Shigeki Watanabe, Ph.D , Grant Kusick
      Sponsored By: Leica Microsystems
      8
      DEC 01, 2022 | 7:00 AM
      Fighting Pandemics and Building a Healthier and more Equitable World - Getting back on track to end AIDS
      Fighting Pandemics and Building a Healthier and more Equitable...
      Date: December 01, 2022 Time: 7:00am (PST), 10:00pm (EST), 4:00pm (CET) Achievement of the UNAIDS 95-95-95 targets is in danger. Gaps are attributed to reaching key populations and equitable...
      Speaker: Dr. Deborah Birx , Solange Baptiste , Dr. Meg Doherty , Regan Hofmann , Micheal Ighodaro
      Sponsored By: Abbott
      23
      NOV 01, 2022 | 6:00 AM
      Vertical rotors and how to achieve higher purity and yield viral vectors with greater efficiency
      Vertical rotors and how to achieve higher purity and yield viral...
      Date: November 01, 2022 Time: 6:00am (PDT), 9:00pm (EDT), 3:00pm (CEST) Density gradient ultracentrifugation is known to provide high purity and high yield viral vector separations required...
      Speaker: Shawn Sternisha PhD
      Sponsored By: Beckman Coulter Life Sciences
      10
      MAR 09, 2022 | 10:00 AM
      Time-resolved electron microscopy: synaptic ultrastructure millisecond by millisecond with high-pressure freezing
      Time-resolved electron microscopy: synaptic ultrastructure millisecond...
      Date: March 09, 2022 Time: 10:00am (PST), 1:00pm (EST), 7:00pm (CEST) Transmission electron microscopy reveals the architecture of cells at nanometer resolution, but chemical fixation severe...
      Speaker: Shigeki Watanabe, Ph.D , Grant Kusick
      Sponsored By: Leica Microsystems
      5
      FEB 01, 2022 | 8:00 AM
      Iterative Genome Engineering for Rapid Improvement of Protein Activity and Production
      Iterative Genome Engineering for Rapid Improvement of Protein...
      Date: February 01, 2021 Time: 08:00am (PST), 11:00am (EST) The Design–Generate–Test–Learn (DGTL) cycle represents an efficient approach to biological engineering, from sing...
      Speaker: Eric Abbate
      Sponsored By: Inscripta
      13 1
      APR 21, 2021 | 12:00 AM
      Flex Analysis: A Safe, Integrated and Flexible Approach to Non-Invasive Aneuploidy Analysis
      Flex Analysis: A Safe, Integrated and Flexible Approach to Non-Invasive...
      NGS Bioinformatics software has come of age. Our workflows need software solutions that don’t only carry out the correct calculations to give the correct results reliably and unambiguo...
      Speaker: Matthew C. Forman, PhD
      Presented at: Genetics Week Virtual Event Series 2021
      1
      APR 07, 2021 | 12:00 AM
      Characterisation and Scale Translation of a parallel Microbioreactor System for Cell Culture Process Development
      Characterisation and Scale Translation of a parallel Microbioreactor...
      The advancement of microbioreactor technology in recent years has transformed early- and mid-stage process development. Their monitoring and control capabilities not only promote the rapid a...
      Speaker: Frank Baganz, PhD
      Presented at: Bioprocessing Virtual Event Series 2021
      1
      OCT 15, 2020 | 8:00 AM
      Zonal Rotor Ultracentrifugation: An Effective Tool for Nanoparticle Separations at Large Scale
      Zonal Rotor Ultracentrifugation: An Effective Tool for Nanoparticle...
      DATE: October 15, 2020 TIME: 8am PDT, 11am EDT Density gradient centrifugation is an effective method for the isolation and purification of small particles. Hollow rotors capable of hosting...
      Speaker: Dr. Alexander Wittemann , Dr. Simone Plueisch
      Sponsored By: Beckman Coulter Life Sciences
      9
      JUL 01, 2020 | 2:00 PM
      Operational strategies in molecular profiling of lung cancers
      Operational strategies in molecular profiling of lung cancers
      Lung cancer management has changed over the last few years with several actionable targets being recognised and mandated in the optimal management of these patients. The biomarker ordering p...
      Speaker: Sudha Murthy, MD
      Presented at: APJ Virtual Genetic Solutions Tour 2020
      1
      JUN 12, 2019 | 10:00 AM
      Unlocking the Potential of the Laboratory through Clinical Decision Support
      Unlocking the Potential of the Laboratory through Clinical Decision...
      DATE: June 12, 2019TIME: 10:00am PT/1:00pm ET With the ever-changing healthcare ecosystem, you are being asked to continually perform better than ever before. Your patients con...
      Speaker: Todd Wharton, RN , Katherine Metz, BSN, MBA, RN
      Sponsored By: Abbott Diagnostics
      3
      OCT 10, 2018 | 9:00 AM
      Understanding Cancer Through Whole-Genome Screening
      Understanding Cancer Through Whole-Genome Screening
      High-throughput screening is widely useful in identifying genes and pathways that drive changes in cell behavior such as cell cycle regulation, metastasis, and drug resistance.  Millipor...
      Speaker: Andrew Ravanelli, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
      Sponsored By: MilliporeSigma
      5
      MAY 10, 2017 | 12:00 PM
      Ask the Expert: Mammalian Transient Expression
      Ask the Expert: Mammalian Transient Expression
      Getting started Equipment Troubleshooting Scale up or scale down your expression runs Tackling difficult-to-express proteins 293 vs. CHO cell expression...
      Speaker: Henry Chiou, PhD , Richard Altman, MS , Jon Zmuda, PhD , Konrad Miatkowski
      Presented at: 2017 Gibco ExpressionWorld
      3
      JUN 30, 2016 | 7:30 AM
      Proteome centric precision medicine:  embracing pathological diversity
      Proteome centric precision medicine: embracing pathological diversity
      Precision medicine requires success in two intertwined aspects: precision therapy and personalized medicine. Precision therapy is being able to effectively treat the right disease; to have th...
      Speaker: Jennifer Van Eyk, PhD
      Presented at: Beckman Coulter Life Sciences Virtual Trade Show
      Sponsored By: Beckman Coulter Life Sciences, Beckman Coulter Life Sciences
      8
      FEB 24, 2016 | 8:00 AM
      Keynote Presentation - Integrating the digital universe of data with consumer-driven mobile apps and large-scale panomics data to better understand, treat, and prevent disease
      Keynote Presentation - Integrating the digital universe of data...
      One of the primary goals of precision medicine is the aggregation and interpretation of deep, longitudinal patient-specific data in the context of the digital universe of information, using a...
      Speaker: Eric Schadt, PhD
      Presented at: Precision Medicine Virtual Event Series 2016
      2
      JAN 21, 2016 | 8:00 AM
      How to identify key genes with CRISPR-Cas9 and shRNA screens
      How to identify key genes with CRISPR-Cas9 and shRNA screens
      DATE:  January 21, 2016 TIME:   8am Pacific time, 11am Eastern time In this webinar, you will learn:  basics of pooled lentiviral screening workflows implications of ...
      Speaker: Anja Smith, PhD
      Sponsored By: Dharmacon, Dharmacon
      18 1
      MAY 13, 2015 | 10:30 AM
      Population Scale Human Genome Analysis on the Cloud
      Population Scale Human Genome Analysis on the Cloud
      Advanced sequencing technologies have made population scale whole genome sequencing a possibility. However, current strategies for analysis of this data rely upon parallelization approaches t...
      Speaker: Peter White, PhD, James Hirmas
      Presented at: Genetics and Genomics Virtual Event Series 2015
      4
    OCT 24, 2023 | 10:00 AM
    An epic advance in epigenomics: Automated CUT&RUN enables chromatin profiling for scaled research & drug discovery applications
    An epic advance in epigenomics: Automated CUT&RUN enables chromatin...
    Dynamic changes in chromatin drive gene expression programs during cellular development and contribute to pathological changes underlying disease. To date, efforts to characterize chromatin...
    Speaker: Andrea Johnstone, Ph.D. , Lori Euler
    Sponsored By: Beckman Coulter Life Sciences
    30
    JUN 06, 2023 | 9:00 AM
    Time-resolved electron microscopy: synaptic ultrastructure millisecond by millisecond with high-pressure freezing
    Time-resolved electron microscopy: synaptic ultrastructure millisecond...
    Transmission electron microscopy reveals the architecture of cells at nanometer resolution, but chemical fixation severely warps their native structure. The true ultrastructure of cells can...
    Speaker: Shigeki Watanabe, Ph.D , Grant Kusick
    Sponsored By: Leica Microsystems
    8
    DEC 01, 2022 | 7:00 AM
    Fighting Pandemics and Building a Healthier and more Equitable World - Getting back on track to end AIDS
    Fighting Pandemics and Building a Healthier and more Equitable...
    Date: December 01, 2022 Time: 7:00am (PST), 10:00pm (EST), 4:00pm (CET) Achievement of the UNAIDS 95-95-95 targets is in danger. Gaps are attributed to reaching key populations and equitable...
    Speaker: Dr. Deborah Birx , Solange Baptiste , Dr. Meg Doherty , Regan Hofmann , Micheal Ighodaro
    Sponsored By: Abbott
    23
    NOV 01, 2022 | 6:00 AM
    Vertical rotors and how to achieve higher purity and yield viral vectors with greater efficiency
    Vertical rotors and how to achieve higher purity and yield viral...
    Date: November 01, 2022 Time: 6:00am (PDT), 9:00pm (EDT), 3:00pm (CEST) Density gradient ultracentrifugation is known to provide high purity and high yield viral vector separations required...
    Speaker: Shawn Sternisha PhD
    Sponsored By: Beckman Coulter Life Sciences
    10
    MAR 09, 2022 | 10:00 AM
    Time-resolved electron microscopy: synaptic ultrastructure millisecond by millisecond with high-pressure freezing
    Time-resolved electron microscopy: synaptic ultrastructure millisecond...
    Date: March 09, 2022 Time: 10:00am (PST), 1:00pm (EST), 7:00pm (CEST) Transmission electron microscopy reveals the architecture of cells at nanometer resolution, but chemical fixation severe...
    Speaker: Shigeki Watanabe, Ph.D , Grant Kusick
    Sponsored By: Leica Microsystems
    5
     
     
  • FEB 01, 2022 | 8:00 AM
    Iterative Genome Engineering for Rapid Improvement of Protein Activity and Production
    Iterative Genome Engineering for Rapid Improvement of Protein...
    Date: February 01, 2021 Time: 08:00am (PST), 11:00am (EST) The Design–Generate–Test–Learn (DGTL) cycle represents an efficient approach to biological engineering, from sing...
    Speaker: Eric Abbate
    Sponsored By: Inscripta
    13 1
    APR 21, 2021 | 12:00 AM
    Flex Analysis: A Safe, Integrated and Flexible Approach to Non-Invasive Aneuploidy Analysis
    Flex Analysis: A Safe, Integrated and Flexible Approach to Non-Invasive...
    NGS Bioinformatics software has come of age. Our workflows need software solutions that don’t only carry out the correct calculations to give the correct results reliably and unambiguo...
    Speaker: Matthew C. Forman, PhD
    Presented at: Genetics Week Virtual Event Series 2021
    1
    APR 07, 2021 | 12:00 AM
    Characterisation and Scale Translation of a parallel Microbioreactor System for Cell Culture Process Development
    Characterisation and Scale Translation of a parallel Microbioreactor...
    The advancement of microbioreactor technology in recent years has transformed early- and mid-stage process development. Their monitoring and control capabilities not only promote the rapid a...
    Speaker: Frank Baganz, PhD
    Presented at: Bioprocessing Virtual Event Series 2021
    1
    OCT 15, 2020 | 8:00 AM
    Zonal Rotor Ultracentrifugation: An Effective Tool for Nanoparticle Separations at Large Scale
    Zonal Rotor Ultracentrifugation: An Effective Tool for Nanoparticle...
    DATE: October 15, 2020 TIME: 8am PDT, 11am EDT Density gradient centrifugation is an effective method for the isolation and purification of small particles. Hollow rotors capable of hosting...
    Speaker: Dr. Alexander Wittemann , Dr. Simone Plueisch
    Sponsored By: Beckman Coulter Life Sciences
    9
    JUL 01, 2020 | 2:00 PM
    Operational strategies in molecular profiling of lung cancers
    Operational strategies in molecular profiling of lung cancers
    Lung cancer management has changed over the last few years with several actionable targets being recognised and mandated in the optimal management of these patients. The biomarker ordering p...
    Speaker: Sudha Murthy, MD
    Presented at: APJ Virtual Genetic Solutions Tour 2020
    1
     
     
  • JUN 12, 2019 | 10:00 AM
    Unlocking the Potential of the Laboratory through Clinical Decision Support
    Unlocking the Potential of the Laboratory through Clinical Decision...
    DATE: June 12, 2019TIME: 10:00am PT/1:00pm ET With the ever-changing healthcare ecosystem, you are being asked to continually perform better than ever before. Your patients con...
    Speaker: Todd Wharton, RN , Katherine Metz, BSN, MBA, RN
    Sponsored By: Abbott Diagnostics
    3
    OCT 10, 2018 | 9:00 AM
    Understanding Cancer Through Whole-Genome Screening
    Understanding Cancer Through Whole-Genome Screening
    High-throughput screening is widely useful in identifying genes and pathways that drive changes in cell behavior such as cell cycle regulation, metastasis, and drug resistance.  Millipor...
    Speaker: Andrew Ravanelli, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
    Sponsored By: MilliporeSigma
    5
    MAY 10, 2017 | 12:00 PM
    Ask the Expert: Mammalian Transient Expression
    Ask the Expert: Mammalian Transient Expression
    Getting started Equipment Troubleshooting Scale up or scale down your expression runs Tackling difficult-to-express proteins 293 vs. CHO cell expression...
    Speaker: Henry Chiou, PhD , Richard Altman, MS , Jon Zmuda, PhD , Konrad Miatkowski
    Presented at: 2017 Gibco ExpressionWorld
    3
    JUN 30, 2016 | 7:30 AM
    Proteome centric precision medicine:  embracing pathological diversity
    Proteome centric precision medicine: embracing pathological diversity
    Precision medicine requires success in two intertwined aspects: precision therapy and personalized medicine. Precision therapy is being able to effectively treat the right disease; to have th...
    Speaker: Jennifer Van Eyk, PhD
    Presented at: Beckman Coulter Life Sciences Virtual Trade Show
    Sponsored By: Beckman Coulter Life Sciences, Beckman Coulter Life Sciences
    8
    FEB 24, 2016 | 8:00 AM
    Keynote Presentation - Integrating the digital universe of data with consumer-driven mobile apps and large-scale panomics data to better understand, treat, and prevent disease
    Keynote Presentation - Integrating the digital universe of data...
    One of the primary goals of precision medicine is the aggregation and interpretation of deep, longitudinal patient-specific data in the context of the digital universe of information, using a...
    Speaker: Eric Schadt, PhD
    Presented at: Precision Medicine Virtual Event Series 2016
    2
     
     
  • JAN 21, 2016 | 8:00 AM
    How to identify key genes with CRISPR-Cas9 and shRNA screens
    How to identify key genes with CRISPR-Cas9 and shRNA screens
    DATE:  January 21, 2016 TIME:   8am Pacific time, 11am Eastern time In this webinar, you will learn:  basics of pooled lentiviral screening workflows implications of ...
    Speaker: Anja Smith, PhD
    Sponsored By: Dharmacon, Dharmacon
    18 1
    MAY 13, 2015 | 10:30 AM
    Population Scale Human Genome Analysis on the Cloud
    Population Scale Human Genome Analysis on the Cloud
    Advanced sequencing technologies have made population scale whole genome sequencing a possibility. However, current strategies for analysis of this data rely upon parallelization approaches t...
    Speaker: Peter White, PhD, James Hirmas
    Presented at: Genetics and Genomics Virtual Event Series 2015
    4
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