OCT 10, 2018 09:00 AM PDT

Understanding Cancer Through Whole-Genome Screening

SPONSORED BY: MilliporeSigma
C.E. CREDITS: P.A.C.E. CE | Florida CE
Speakers
  • Senior R&D Scientist, Genome and Epigenome Editing, MilliporeSigma
    Biography
      Andrew has spent more than a decade using genetic manipulation and analysis to dissect molecular mechanisms involved in cell fate specification and behavior in cell culture and in animal models of development and disease. He earned his Ph.D. in Cell Biology from Duke University and completed a postdoctoral fellowship in Pediatrics at the University of Colorado School of Medicine, developing expertise in high-throughput screening, developmental neuroscience, and gene editing. Andrew joined MilliporeSigma in 2016 and has been developing new tools and strategies to modulate gene expression using CRISPR-Cas9.

    Abstract:

    High-throughput screening is widely useful in identifying genes and pathways that drive changes in cell behavior such as cell cycle regulation, metastasis, and drug resistance.  MilliporeSigma develops and distributes a comprehensive portfolio of functional genomics tools for efficient, high quality, genome-scale analysis of cellular processes.  In this webinar, we will demonstrate the utility of three genome-wide approaches to unbiased identification of relevant gene pathways for cancer discovery: shRNA knock-down, CRISPR knock-out, and CRISPR activator libraries.

    Learning Objectives: 

    1. Learn how to select reagents for whole-genome screens
    2. Learn about complementarity between screening technologies 
    3. Learn example methods for candidate validation


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