OCT 10, 2018 9:00 AM PDT

Understanding Cancer Through Whole-Genome Screening

Sponsored by: MilliporeSigma
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Senior R&D Scientist, Genome and Epigenome Editing, MilliporeSigma
    Biography
      Andrew obtained his Ph.D. in Cell Biology from Duke University, where he used mouse and zebrafish models to dissect cellular mechanisms of early tissue formation. He completed a postdoctoral fellowship in Pediatrics at the University of Colorado School of Medicine where he used pharmacological and genetic manipulations coupled with 4D imaging to investigate cell fate specification in the brain and spinal cord. Andrew joined MilliporeSigma in 2016 and has been developing novel mechanisms to modulate gene expression using CRISPR-Cas9.

    Abstract

    High-throughput screening is widely useful in identifying genes and pathways that drive changes in cell behavior such as cell cycle regulation, metastasis, and drug resistance.  MilliporeSigma develops and distributes a comprehensive portfolio of functional genomics tools for efficient, high quality, genome-scale analysis of cellular processes.  In this webinar, we will demonstrate the utility of three genome-wide approaches to unbiased identification of relevant gene pathways for cancer discovery: shRNA knock-down, CRISPR knock-out, and CRISPR activator libraries.

    Learning Objectives: 

    1. Learn how to select reagents for whole-genome screens
    2. Learn about complementarity between screening technologies 
    3. Learn example methods for candidate validation


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