JAN 20, 2020 6:35 PM PST

Did you know these non-cancer drugs can also fight cancer?

A study from MIT. Harvard and the Dana-Farber Cancer Institute has concluded that almost 50 existing non-oncological drugs have anti-cancer properties capable of killing cancer cells. The researchers conducted an extensive review of thousands of drug compounds and published their findings recently in the journal Nature Cancer.

"We thought we'd be lucky if we found even a single compound with anti-cancer properties, but we were surprised to find so many," said Todd Golub. Golub is the chief scientific officer and director of the Cancer Program at the Broad, Charles A. Dana Investigator in Human Cancer Genetics at Dana-Farber, and a professor of pediatrics at Harvard Medical School.

The work pulled from a dataset of over 6,000 FDA-approved drugs and compounds called Broad's Drug Repurposing Hub. The majority of the drugs are not purposed for cancer. The founder of the Hub, Steven Corsello, is also the first author of the study and an oncologist at Dana-Farber. "We created the repurposing hub to enable researchers to make these kinds of serendipitous discoveries in a more deliberate way.”

In conducting their analysis, the researchers utilized a method of molecular barcoding called PRISM, which tags cell lines of human cancer cells (578 in all) with DNA barcodes, which were then exposed to varying compounds and drugs. From this, they found almost fifty drugs – not specified for cancer – that were successful in killing cancer cells.

Some of these compounds, which were originally meant to lower cholesterol or reduce inflammation, had anti-cancer properties that were surprising. "Most existing cancer drugs work by blocking proteins, but we're finding that compounds can act through other mechanisms," said Corsello. However, as Science Daily explains, the researchers found that many of the non-oncology drugs destroyed “cancer cells that express a protein called PDE3A by stabilizing the interaction between PDE3A and another protein called SLFN12”. Other drugs killed cancer cells by interacting with previously unidentified molecular targets. These findings are revolutionary because offer us new information on how to fight cancer.

New research reports non-oncology drugs are capable of killing cancer cells, too. Photo: Pixabay

"The genomic features gave us some initial hypotheses about how the drugs could be acting, which we can then take back to study in the lab," said Corsello. "Our understanding of how these drugs kill cancer cells gives us a starting point for developing new therapies."

Sources: Science Daily, Nature Cancer

About the Author
  • Kathryn is a curious world-traveller interested in the intersection between nature, culture, history, and people. She has worked for environmental education non-profits and is a Spanish/English interpreter.
You May Also Like
MAR 12, 2020
Cell & Molecular Biology
MAR 12, 2020
Zika Virus Used to Treat Advanced Tumors in Dogs
Researchers found a use for the zika virus; they treated advanced tumors of the central nervous system of three elderly ...
MAR 14, 2020
Technology
MAR 14, 2020
Mass Cytometry Can Bring New Cancer Therapeutics
New technology may soon accelerate cancer therapeutic development. The revolutionary technique is called mass cytometry ...
APR 07, 2020
Cancer
APR 07, 2020
Chemo drugs are leaking into our water
With cancer as the second leading cause of death globally, it comes as a surprise that we know very little up until now ...
APR 23, 2020
Cancer
APR 23, 2020
Doctors, watch out for unexpected side effects in small clinical trials
Doctors who have patients in small-sized clinical trials that test new cancer drugs should be on the look-out for unexpe ...
MAY 02, 2020
Drug Discovery & Development
MAY 02, 2020
Glioblastoma Treatment Using Schizophrenic Drug Plus Radiation
A therapeutic used for the treatment of schizophrenia could be a gateway for targeting glioblastoma, one of the deadlies ...
MAY 21, 2020
Cancer
MAY 21, 2020
When is the best time to talk about end-of-life decisions with your teen who has cancer?
A study published recently in JAMA Network highlights the need for improved pediatric advanced care for adolescents with ...
Loading Comments...