JUL 11, 2020 1:07 PM PDT

New drug combo could improve immunotherapy for SCCOHT ovarian cancer

Research published recently in PLOS ONE reports on SP-2577, a drug that could help girls and young women plagued with a type of ovarian cancer known as Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT). According to researcher Dr. Jeffrey Trent, who has been working on this topic at the Translational Genomics Research Institute (TGen) for years, SP-2577 could tap the immune system to help combat SCCOHT.

In the study, The novel reversible LSD1 inhibitor SP-2577 promotes anti-tumor immunity in SWItch/Sucrose-NonFermentable (SWI/SNF) complex mutated ovarian cancer, the researcher team proposes a two-fold attack, combining SP-2577, or Seclidemstat, with another immunotherapeutic compound. 

"Immunotherapy is the future of cancer treatment. Our combination of drugs should promote an immune response in an ovarian cancer that usually does not respond well to immunotherapies," said lead author Dr. Raffaella Soldi, a TGen Research Associate Professor. "One drug opens a biological gate, while the other drug helps push immune cells through the gate to attack the cancer."

SP-2577 works by inhibiting a protein called LSD1, which is known to play a role in SCCOHT ovarian cancer, among other cancer types. 

"We suggest in this paper that LSD1 inhibition should improve the immune-therapy response in these tumors. This treatment is exquisitely dependent on the mutation found by Dr. Trent and his group. Without that mutation, this treatment would not work," commented senior author Dr. Sunil Sharma, TGen Deputy Director of Clinical Sciences. 

Dr. Sharma is referring to a previous discovery that a single mutation in a gene called SMARCA4 triggered SCCOHT. Interestingly, this gene had been shown before to be associated with lung, brain, and pancreatic cancer.  "The correlation between mutations in SMARCA4 and the development of SCCOHT is simply unmistakable," explained Dr. Trent in reference to this finding.

The SP-2577 and Pembrolizumab combination is soon to be tested in clinical trials for patients with SCCOHT ovarian cancer. 

Sources: PLOS ONE, Eureka Alert

About the Author
  • Kathryn is a curious world-traveller interested in the intersection between nature, culture, history, and people. She has worked for environmental education non-profits and is a Spanish/English interpreter.
You May Also Like
MAY 29, 2020
Cancer
What can we do about drug-induced tetraploidy in cancer cells?
MAY 29, 2020
What can we do about drug-induced tetraploidy in cancer cells?
A paper published in the journal Trends in Cancer describes how cancer therapies sometimes fuel genetic changes in cells ...
JUN 04, 2020
Cancer
Inhibiting the Signals Critical for Cancer Growth in Merkel Cell Carcinoma
JUN 04, 2020
Inhibiting the Signals Critical for Cancer Growth in Merkel Cell Carcinoma
Merkel Cell Carcinoma (MCC) is a highly aggressive cancer of the skin. It is characterized by a high recurrence rate and ...
JUN 06, 2020
Cancer
Developing a Platform to Efficiently Test Antibody-Drug Conjugates
JUN 06, 2020
Developing a Platform to Efficiently Test Antibody-Drug Conjugates
Cancer has been one of the most persistent diseases modern medicine has faced. Due to its nature, treatments are often t ...
JUL 10, 2020
Cancer
Why do black men suffer disproportionately from prostate cancer?
JUL 10, 2020
Why do black men suffer disproportionately from prostate cancer?
Cancer disparities by race are widely acknowledged. One in every six black men will be diagnosed with prostate cancer in ...
JUL 14, 2020
Drug Discovery & Development
How Cancer Cells Influence Drug Responses
JUL 14, 2020
How Cancer Cells Influence Drug Responses
When studying a large number of brain samples, researchers were able to characterize how changes in cells influence drug ...
AUG 05, 2020
Cancer
A New Test to Analyze Cell-Free DNA in Cancer Diagnostics
AUG 05, 2020
A New Test to Analyze Cell-Free DNA in Cancer Diagnostics
Cell-free DNA (cfDNA) are small pieces of genomic DNA that have escaped into the bloodstream either through active relea ...
Loading Comments...