APR 15, 2016 6:41 AM PDT

Study Reveals Gut Bacteria Delayed Onset of Cancers

WRITTEN BY: Xuan Pham
Good gut bacteria can promote a healthy immune system, which in turn, could reduce the risks for some types of cancers, say scientists at UCLA. The study, published in the journal PLOS ONE, finds that a common beneficial bacterial strain slowed the growth of lymphoma in mice through the production of anti-inflammatory metabolites.
 
Lactobacillus johnsonii has anti-inflammatory properties that could reduce cancer risks
The microbiome is a specialized collection of bacteria residing in the human body. Bacterial cells outnumber human cells ten to one: there are about 10 trillion bacteria compared to the 1 trillion human cells in the body. Mostly famous for their existence in the human gut, these communities of microorganisms have been known to influence processes like digestion and immune responses. In some cases, the bacteria can be harmful and have been linked to obesity, stomach cancer, and even male reproductive disorders. However, some collection of bacteria can actually promote health and wellness through their anti-inflammatory properties.
 
In their study, the UCLA team, led by Robert Schiestl, honed in on a specific strain of bacteria known as Lactobacillus johnsonii. This is the most abundant strain of the so-called “good” bacteria in our system, as it has been shown to reduce inflammation and DNA damage. The team also focused on mice genetically engineered to have mutations in ATM – DNA repair gene, which results in a neurologic disorder called ataxia telangiectasia (AT). A high incidence of cancers, such as leukemia and lymphomas, are associated with AT.
 
Separated into two groups, the team exposed one group to only the anti-inflammatory Lactobacillus bacteria, and the other group received mixture of microbes that normally exist in the intestines, including both good and bad bacteria.
 
They found mice with more anti-inflammatory Lactobacillus bacteria had delayed onset of lymphomas. This was published in a previous report in Cancer Research. In the current study, the team found additional evidence for the anti-cancer effects of the Lactobacillus bacteria. Specifically, mice exposed only to Lactobacillus produced metabolites known to protect against cancer, including 3-methylbutyrolactone, kyneurenic acid and 3-methyladenine.
 
The beneficial microbiota also had a role in prolong survival of the mice – they lived four times longer than those that received a mixture of bacteria, and showed less DNA damage overall.
 
 
The results provide good news for health experts and patients all around, as it suggests modulating the amount of good bacteria in your gut could actually have a positive effect on cancer risks. "Since it is a Lactobacillus strain, it makes excellent yogurt, kefir, kombucha and sauerkraut,” Schiestl commented.
 
Ultimately, the team sees chemotherapeutic potential in anti-inflammatory probiotics, which can easily be administered. "It is not invasive and rather easy to do," Schiestl said. “In the future, it is our hope that the use of probiotics-containing [supplements] would be a potential chemopreventive for normal humans, while the same type of microbiota would decrease tumor incidence in cancer susceptible populations."

Additional source: MNT
About the Author
  • I am a human geneticist, passionate about telling stories to make science more engaging and approachable. Find more of my writing at the Hopkins BioMedical Odyssey blog and at TheGeneTwist.com.
You May Also Like
FEB 02, 2021
Immunology
Pumping the Brakes on Stomach Cancer Progression
FEB 02, 2021
Pumping the Brakes on Stomach Cancer Progression
By the time stomach cancer is diagnosed, it’s often bad news for patients. The disease often presents with relativ ...
FEB 11, 2021
Clinical & Molecular DX
Seeing if Hormone Therapy Will Work for Breast Cancer Patients
FEB 11, 2021
Seeing if Hormone Therapy Will Work for Breast Cancer Patients
Only around half of women diagnosed with breast cancer will benefit from hormonal therapy, a cancer treatment that adds, ...
FEB 16, 2021
Cancer
Fecal transplants help melanoma patients
FEB 16, 2021
Fecal transplants help melanoma patients
Introducing new microorganisms to the gut microbiome can improve patients’ response to immunotherapy, suggests res ...
MAR 04, 2021
Clinical & Molecular DX
Is the Cancer Treatment Working? Liquid Biopsies Provide Answers.
MAR 04, 2021
Is the Cancer Treatment Working? Liquid Biopsies Provide Answers.
A newly-developed tool could help physicians monitor the performance of colorectal cancer therapies simply by examining ...
APR 02, 2021
Cancer
Missing link identified for "bad" cholesterol
APR 02, 2021
Missing link identified for "bad" cholesterol
New research from a team at the University of Alberta has identified the protein that is associated with low-density lip ...
MAY 08, 2021
Cancer
More evidence supports the evils of sugary drinks
MAY 08, 2021
More evidence supports the evils of sugary drinks
New research published online in the journal Gut from researchers at the Washington University School of Medicine i ...
Loading Comments...