MAY 19, 2021 3:28 PM PDT

Why Don't Some People Get High from Cannabis Edibles?

WRITTEN BY: Annie Lennon

While eating cannabis products produces a potent high in many, some are unable to feel its effects when consumed in this way. Yet, although the phenomenon is thought to come from more than just a ‘high tolerance’, researchers still can’t quite explain it. 

“We’re only just now starting to understand the cannabinoid system,” says Dr Staci Gruber, the director of the Marijuana Investigations for Neuroscientific Discovery programs at McLean Hospital. “And it’s already clear that it’s not just about what and how much you’re using; it’s about how you’re wired.”

At present, no studies have investigated the reasons behind why some do not respond to marijuana edibles. The use of high potency edibles such as Canndid CBD pouches does have an impact though as well. However, Gruber and her colleagues have a hypothesis. 

Some studies have found that levels of THC metabolites, the breakdown products of psychoactive tetrahydrocannabinol, vary greatly depending on the presence of a certain enzyme that breaks down THC in the liver. Which enzyme a person has depends on which variant of the CPY2C9 gene they have- with some uncommon subtypes producing an enzyme that metabolizes THC faster than normal. 

The researchers thus say that presence of certain genetic subtypes that affect this liver enzyme may account for some people being unable to experience a high from cannabis edibles. They added that how easily people absorb fat may also play a role in their ability to get high from edibles. 

Such a variance in the ability to feel marijuana means that biological marijuana tests currently used by researchers, doctors, police and employers that look for metabolites may not account for variations in metabolic rate. This in turn means that results from these tests may not properly indicate how marijuana affects different people- whether in a medicinal sense or when assessing one’s ability to drive and perform tasks. 

“It underscores the need to understand people’s genetic profiles, and that there are a lot of variables people haven’t considered” when interpreting these tests, says Gruber. 

 

Sources: Boston GlobeInternational Journal of Legal Medicine

 

About the Author
University College London
Annie Lennon is a writer whose work also appears in Medical News Today, Psych Central, Psychology Today, and other outlets. When she's not writing, she is COO of Xeurix, an HR startup that assesses jobfit from gamified workplace simulations.
You May Also Like
JUN 17, 2022
Cannabis Sciences
Projected Increases in Cannabis Use in States Legalizing Recreational Cannabis
JUN 17, 2022
Projected Increases in Cannabis Use in States Legalizing Recreational Cannabis
A study published in the scientific journal Addiction found that people will be more likely to use cannabis as their sta ...
JUL 15, 2022
Cannabis Sciences
Cannabis Legalization's Impact on Foster Care Placements
JUL 15, 2022
Cannabis Legalization's Impact on Foster Care Placements
A study published in the journal Economic Inquiry analyzed the potential impacts of federal cannabis legalization on fos ...
AUG 04, 2022
Cannabis Sciences
Don't Smoke the Reclaim. Here's Why.
AUG 04, 2022
Don't Smoke the Reclaim. Here's Why.
Here's what reclaim is, why you should leave it alone, and what you should do with it instead.
AUG 18, 2022
Cannabis Sciences
Metered-Dose Inhalers Offer Effective Dosing for Medical Cannabis Patients
AUG 18, 2022
Metered-Dose Inhalers Offer Effective Dosing for Medical Cannabis Patients
A recent study published in Canadian Journal of Health Technologies examined the effectiveness of using metered-dose inh ...
SEP 08, 2022
Health & Medicine
Cannabis Users Were Less Likely to End up in ICU for Covid-19
SEP 08, 2022
Cannabis Users Were Less Likely to End up in ICU for Covid-19
A study comparing cannabis and non-cannabis users hospitalized for COVID-19 found that cannabis users were less likely t ...
OCT 25, 2022
Cannabis Sciences
The Role of Terpenes in Cannabis
OCT 25, 2022
The Role of Terpenes in Cannabis
Terpenes play a major role in the makeup and character of various cannabis strains. Here's what they do.
Loading Comments...