JUN 14, 2016 1:31 PM PDT

One Tiny RNA Could Break the Cycle of Arterial Thrombosis

WRITTEN BY: Kara Marker
Medication to dissolve blood clots and various surgical procedures can be done to reverse damage done to arteries with obstructive blood clots, a condition called arterial thrombosis. However, scientists have discovered a more natural way to resolve this condition to prevent increased risk of heart attack and stroke, and without resorting to invasive surgery.
Image Credit: UNC School of Medicine
MicroRNAs (miRNAs) are tiny molecules that play a big role in gene expression regulation. At only 22 nucleotides long, these single-stranded molecules are some of the shortest of known genetic material, and scientists in a new study published in The FASEB Journal believe their gene expression regulation capabilities could extend to proteins and genes involved in the development of arterial thrombosis.
 
In their study, scientists from Brigham and Women’s Hospital drew upon previous knowledge that a specific type of microRNA called miR-181b regularly balances the impact of both acute and vascular inflammation. Arterial thrombosis often results from arterial damage due to atherosclerosis, a condition that consists of plaque deposits in the blood vessels that can be exacerbated by inflammation. When these atherosclerotic plaques rupture, obstructive blood clots can form.
 
They saw that miR-181b targets a protein called Card10, which is involved in activating inflammation through apoptosis signaling and other highly specific interactions with other proteins. If inflammation isn’t under the right control, blood clots can form continuously, causing a “vicious cycle” of arterial thrombosis.
 
Building on this observation, researchers conducted preclinical studies of mouse models of thrombosis in the carotid artery. When they delivered a supply of miR-181b to these mice, they saw a 73 percent reduction in blood clot formation as well as a significant increase in the time the arteries took to become blocked. Similarly, when they went right to the suspected source of the blood clot formation, Card10, and directly blocked its activity, they saw the same trends in reduction.
 
Corresponding author Mark Feinberg explained the study’s significance:

“Delivery of miR-181b or Card10 inhibition may constitute a new therapeutic approach to reduce arterial thrombosis.”

 
This study has significant implications for conditions closely related to arterial thrombosis: heart attack, stroke, and peripheral artery disease.
 

 
Sources: Brigham and Women’s Hospital, Exiqon, National Health Service, Gene Cards Human Gene Database
 
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
DEC 01, 2019
Plants & Animals
DEC 01, 2019
Blue Whales Exhibit 'Extremely Low' Heart Rates When Performing Deep Dives
Blue whales have a reputation for being massive, and as far as we know, they’re the largest living animal in exist ...
FEB 05, 2020
Cardiology
FEB 05, 2020
Protein-Rich Foods May Damage Heart Health
High-protein diets are becoming more and more popular as a method to both increase muscle mass and lose weight. Now howe ...
APR 17, 2020
Cardiology
APR 17, 2020
How Men and Women Develop Heart Disease Differently
In the US alone, approximately 182,000 heart valve replacements are performed every year. Now, researchers from McGill U ...
APR 27, 2020
Cardiology
APR 27, 2020
Almost Half of College Female Athletes Have High Blood Pressure
According to the World Health Organization (WHO) an estimated 1.13 billion people worldwide have hypertension, or high b ...
MAY 04, 2020
Cardiology
MAY 04, 2020
Machine Learning May Help in the Diagnosis of Inherited High Cholesterol
Familial hypercholesterolemia, or FH, is an inherited genetic mutation in how the body recycles LDL cholesterol (bad cho ...
MAY 28, 2020
Cannabis Sciences
MAY 28, 2020
Cannabis-Free CBD More Effective than Regular CBD
Commonly known to come from the cannabis plant or hemp, cannabidiol (CBD) can also be found in a range of other plants. ...
Loading Comments...