JUN 14, 2016 1:31 PM PDT

One Tiny RNA Could Break the Cycle of Arterial Thrombosis

WRITTEN BY: Kara Marker
Medication to dissolve blood clots and various surgical procedures can be done to reverse damage done to arteries with obstructive blood clots, a condition called arterial thrombosis. However, scientists have discovered a more natural way to resolve this condition to prevent increased risk of heart attack and stroke, and without resorting to invasive surgery.
Image Credit: UNC School of Medicine
MicroRNAs (miRNAs) are tiny molecules that play a big role in gene expression regulation. At only 22 nucleotides long, these single-stranded molecules are some of the shortest of known genetic material, and scientists in a new study published in The FASEB Journal believe their gene expression regulation capabilities could extend to proteins and genes involved in the development of arterial thrombosis.
 
In their study, scientists from Brigham and Women’s Hospital drew upon previous knowledge that a specific type of microRNA called miR-181b regularly balances the impact of both acute and vascular inflammation. Arterial thrombosis often results from arterial damage due to atherosclerosis, a condition that consists of plaque deposits in the blood vessels that can be exacerbated by inflammation. When these atherosclerotic plaques rupture, obstructive blood clots can form.
 
They saw that miR-181b targets a protein called Card10, which is involved in activating inflammation through apoptosis signaling and other highly specific interactions with other proteins. If inflammation isn’t under the right control, blood clots can form continuously, causing a “vicious cycle” of arterial thrombosis.
 
Building on this observation, researchers conducted preclinical studies of mouse models of thrombosis in the carotid artery. When they delivered a supply of miR-181b to these mice, they saw a 73 percent reduction in blood clot formation as well as a significant increase in the time the arteries took to become blocked. Similarly, when they went right to the suspected source of the blood clot formation, Card10, and directly blocked its activity, they saw the same trends in reduction.
 
Corresponding author Mark Feinberg explained the study’s significance:

“Delivery of miR-181b or Card10 inhibition may constitute a new therapeutic approach to reduce arterial thrombosis.”

 
This study has significant implications for conditions closely related to arterial thrombosis: heart attack, stroke, and peripheral artery disease.
 

 
Sources: Brigham and Women’s Hospital, Exiqon, National Health Service, Gene Cards Human Gene Database
 
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
JUN 27, 2020
Cardiology
Automating the Analysis of the Circle of Willis to Determine Vascular Health
JUN 27, 2020
Automating the Analysis of the Circle of Willis to Determine Vascular Health
The Circle of Willis (CoW) is a vital part of the brain’s anatomy that acts as a junction of blood flow. It i ...
JUL 02, 2020
Cardiology
Managing the Mitochondria After a Heart Attack
JUL 02, 2020
Managing the Mitochondria After a Heart Attack
Heart attacks are an unfortunately common occurrence across the country. One of the biggest consequences of a heart atta ...
JUL 03, 2020
Cardiology
How Diet and Gut Microbes May Impact Artery Health
JUL 03, 2020
How Diet and Gut Microbes May Impact Artery Health
Researchers are learning how dietary choices may be causing damage to the arteries as people age.
JUL 09, 2020
Cardiology
How Exercise Can Affect Blood Chemistry
JUL 09, 2020
How Exercise Can Affect Blood Chemistry
Nowadays, the health benefits of exercise seem to be advertised everywhere. While it is true that exercise has many bene ...
JUL 09, 2020
Cardiology
Broken Heart Syndrome Found to Increase During Pandemic
JUL 09, 2020
Broken Heart Syndrome Found to Increase During Pandemic
Reporting in JAMA Network Open, scientists have found that broken heart syndrome, called stress cardiomyopathy, has been ...
NOV 20, 2020
Neuroscience
The Link Between Sleep Apnea and Autoimmune Disease
NOV 20, 2020
The Link Between Sleep Apnea and Autoimmune Disease
Researchers from the University of Georgia have found more evidence for the link between obstructive sleep apnea (OSA) a ...
Loading Comments...