OCT 17, 2016 7:40 PM PDT

Gene Therapy to Prevent Heart Failure

WRITTEN BY: Kara Marker
For reasons not completely understood by scientists, our own heart muscle cells, called cardiomyocytes, secrete a protein that ultimately leads to heart failure. In a new study from Kumamoto University, researchers find out why and how to stop it.
Angiopoietin-like protein 2 (ANGPTL2) reduces the contractile force of the heart by both decreasing the production of cellular energy and the ability of calcium concentration to be regulated within the cardiomyocytes. Excessive secretion of these proteins occurs when aged cells and/or cells under stress due to high blood pressure, the researchers found in the recent Nature Communications study, which investigated the potential of developing gene therapy to treat ANGPTL-2-related heart failure.

"We genetically engineered a non-pathogenic virus which was designed to infect cardiac muscle cells and reproduce a special RNA molecule that inhibit the production of the ANGPTL2 protein," said Kumamoto University Professor Yuichi Oike. “Among knockout mice that could not produce [ANGPTL2], the development of heart failure was suppressed in a manner similar to moderate exercise.”

Oike’s study suggests gene therapy to inhibit production of ANGPTL2, which could provide beneficial therapeutic effects for people at risk of heart failure. Oike showed that these beneficial effects are possible in both a heart failure mouse model and in human cardiomyocytes differentiated from induced pluripotent stem cells (iPSCs), due to a correction in calcium concentration regulation and energy production when ANGPLT2 production was suppressed.

Excessive secretion of ANGPTL2 by cells experiencing stress causes chronic inflammation, which leads to heart failure but also other lifestyle-related diseases like atherosclerosis, obesity, diabetes, and cancer. The protein causes the development of these diseases because of its debilitating effect on the contractile force of the heart, but the good news is that moderate exercise can reduce its excessive production by cardiomyocytes, which is one of the reasons regular physical activity is famous for maintaining a healthy heart.

Individuals with severe heart failure are only 50 to 60 percent likely to survive five years, so an effective gene therapy could give thousands of Americans with heart failure a much better prognosis. 
 


Sources: Kumamoto University, American Heart Association
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
JAN 25, 2021
Cardiology
Obesity's Poor Health Impact Not Overcome by Exercise
JAN 25, 2021
Obesity's Poor Health Impact Not Overcome by Exercise
While there has been limited evidence that activity and fitness can counter the health impacts of excess body fat, a new ...
FEB 10, 2021
Cardiology
Finding the Link Between Air Pollution & Heart Disease
FEB 10, 2021
Finding the Link Between Air Pollution & Heart Disease
While many studies have shown that air pollution is linked to negative health impacts including poor cardiovascular heal ...
MAR 25, 2021
Cardiology
Improved Triage Method to Get STEMI Patients from Door to Treatment
MAR 25, 2021
Improved Triage Method to Get STEMI Patients from Door to Treatment
A heart attack is an incredibly sudden and dangerous cardiac event that requires quick action for a successful recovery. ...
MAR 29, 2021
Cardiology
Learning More About How Stress Breaks the Heart
MAR 29, 2021
Learning More About How Stress Breaks the Heart
Scientists are learning more about what causes a real phenomenon known as broken heart syndrome, or stress-related cardi ...
APR 13, 2021
Cardiology
Can a Ketosis Metabolite Act as a Biomarker for Cardiovascular Diseases?
APR 13, 2021
Can a Ketosis Metabolite Act as a Biomarker for Cardiovascular Diseases?
Quick and reliable diagnostics are the key to controlling many diseases, including cardiovascular disease. Biomarkers ar ...
JUN 29, 2021
Immunology
The Heartbreaking Nature of COVID Revealed
JUN 29, 2021
The Heartbreaking Nature of COVID Revealed
Researchers at the Washington University School are getting to the root of heart damage resulting from COVID-19 infectio ...
Loading Comments...