SEP 07, 2017 2:50 PM PDT

Fixing What Goes Wrong During Sepsis

WRITTEN BY: Kara Marker

A lot of things go wrong during sepsis, but one of the worst is heart complications. In the past researchers determined that boosting energy production in the heart could help, but they didn’t know why. The most recent study, from the same group of scientists, provides an explanation and a plan of action.

3D rendering of mouse brain cortex. Credit: Antonino Paolo Di Giovanna

Sepsis is an extreme overreaction to a bacterial infection, causing blood clots, faulty blood vessels, and organ failure. Heart complications are responsible for 80 percent of sepsis-related deaths, and scientists from Temple University want to alleviate some of the devastation with their new findings.

What happens to the heart during sepsis? It becomes weak and fails to generate enough energy to pump effectively due to systemic inflammation. When the heart can’t pump effectively, oxygenated blood doesn’t make it to the cells and tissues of the body, and organ failure ensues. The new Temple University study began to identify and explain the mechanism responsible for the heart’s loss of energy during sepsis. If they can prevent the heart from losing energy, they could potentially increase the amount of time anti-inflammatory drugs have to be effective to treat sepsis.

“Anti-inflammatory therapies fail to improve survival,” explained senior investigator Konstantinos Drosatos, PhD. “We think that this happens because there simply is not enough time for the anti-inflammatory drugs to begin working before critical organs begin to fail."

Konstantinos and her team worked with a mouse model of sepsis, treating heart muscle cells with lipopolysaccharide, an endotoxin produced by many types of bacteria that triggers the immune system and induces sepsis. However, they blocked activation of NADPH oxidase 2 (NOX2), an enzyme active during infections that can become toxic if overproduced. They knew to do so because of its connection to boosting oxidative stress in the heart.

"Increased levels of reactive oxygen species are a key feature of cardiac dysfunction during sepsis," Drosatos explained. "Mitochondria, the energy powerhouses of cells, are especially vulnerable to damage from reactive molecules, and this seems to be critical for energy production in the heart and maybe other organs."

Inhibiting the activity of NOX2 lowered oxidative stress in the face of sepsis, and it boosted the heart’s ability to produce energy. Drosatos believes that blocking NOX2 along with applying traditional drugs could increase survival following sepsis and wants to pursue human clinical trials in the near future.

"With our latest findings, supportive and anti-inflammatory treatments would remain a mainstay,” Drosatos explained. “But by also ensuring that the heart is producing energy, we could provide extra time for the treatments to work before the heart fails.”

The present study was published in the Journal of Clinical Investigation Insight.

Sources: MedlinePlus, Journal of Endotoxin Research, Cellular & Molecular Immunology, Temple University Health System

About the Author
I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
MAR 29, 2022
Cardiology
Heart Disease Patients Show Altered Gut Microbiomes
MAR 29, 2022
Heart Disease Patients Show Altered Gut Microbiomes
Two recent studies have linked disturbed gut microbiomes to cardiovascular disease.
MAY 25, 2022
Clinical & Molecular DX
Deadly Heart Arrhythmia Linked to Air Pollution May be Avoidable
MAY 25, 2022
Deadly Heart Arrhythmia Linked to Air Pollution May be Avoidable
Doctors at the Maggiore Hospital in Bologna, Italy noticed that on days with high levels of air pollution, clusters of p ...
JUN 04, 2022
Drug Discovery & Development
3g of Omega-3 Fatty Acids Daily May Lower Blood Pressure
JUN 04, 2022
3g of Omega-3 Fatty Acids Daily May Lower Blood Pressure
Around 3g of omega-3 fatty acids taken on a daily basis may be the optimal dose for lowering blood pressure. The corresp ...
JUN 12, 2022
Plants & Animals
Vegan Diet Rich in Legumes Helps with Weight Loss
JUN 12, 2022
Vegan Diet Rich in Legumes Helps with Weight Loss
New research conducted by the Physicians Committee for Responsible Medicine suggests that a vegan diet offers a range of ...
JUN 23, 2022
Cardiology
Nordic Walking Improves Life for Heart Disease Patients
JUN 23, 2022
Nordic Walking Improves Life for Heart Disease Patients
A new study has shown that Nordic walking improves functional capacity and other symptoms in heart disease patients.
JUL 21, 2022
Clinical & Molecular DX
Scientists Find a Potential Cause and Treatment for Shorter Life Span in Men
JUL 21, 2022
Scientists Find a Potential Cause and Treatment for Shorter Life Span in Men
Scientists are beginning to understand the significant impact of a process called hematopoietic mosaic loss of Y chromos ...
Loading Comments...