DEC 07, 2017 5:32 AM PST

Treating Heart Failure by Targeting a Mitochondrial Protein

WRITTEN BY: Kara Marker

One explanation for why heart failure develops goes all the way to the miniscule organelles inside individual cells. From Georgia State University, researchers from a new study show how one mitochondrial protein, FUNDC1, is connected to heart dysfunction and, ultimately, heart failure.

An electron micrograph image of a cell with several mitochondria surrounding the nucleus. Credit: Wikimedia User T. Voekler

Understanding FUNDC1

FUNDC1 is an outer mitochondrial membrane protein whose function has yet to be entirely explained. What scientists from the current study do know, though, is that reducing its levels in heart muscle cells, called cardiomyocytes, initiates cardiac dysfunction and makes existing dysfunction worse.

Additionally, intervention between FUNDC1’s interaction with certain protein receptors blocks the release of calcium from an organelle called the endoplasmic reticulum (ER), preventing calcium from reaching the mitochondria. This leads to a plethora of problems stemming from mitochondrial and cardiac dysfunction, ultimately resulting in heart failure.

Powerhouse of the Cell

As the infamous “powerhouses of the cell,” the mitochondria are responsible for several vital roles in the cell, and thus, in the body as a whole:

  • Energy production

  • Reactive oxygen species generation

  • Signal transduction

In the heart, mitochondria play a particularly important role, providing energy for “optimal cardiac performance.” Thus, a disruption in mitochondrial function in cardiomyocytes will always mean a disruption in heart function.

The relationship between mitochondria and the ER

Mitochondria and the ER are physically interconnected via mitochondria-associated ER membranes (MAMs). When the connections between the two are disrupted, several diseases can develop, including Alzheimer’s and Parkinson’s, but the details of how this happens are fuzzy.

In their study, Georgia State researchers used echocardiography to monitor heart function in several situations:

  • Mouse neonatal cardiomyocytes

  • Mice lacking FUNDC1 gene

  • Control mice

  • Cardiac tissues of heart failure patients

The genetically deficient mice showed several issues involved in heart function, including muscle scarring, compared to control mice.

True for human hearts too?

“The formation of MAMs mediated by the mitochondrial membrane protein FUNDC1 was significantly suppressed in patients with heart failure, which provides evidence that FUNDC1 and MAMs actively participate in the development of heart failure," explained Georgia State’s Dr. Ming-Hui Zou.

The findings from the study indicate a new potential treatment approach, rejuvenating MAMs to promote both mitochondrial and cardiac function.

Going forward, Zou said, “this work has important clinical implications and provides support that restoring proper function of MAMs may be a novel target for treating heart failure."

The present study was published in the journal Circulation.

Source: Georgia State University

About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
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