AUG 01, 2016 8:57 AM PDT

Updates From the FaceBase Consortium

WRITTEN BY: Carmen Leitch
The FaceBase Consortium was established in 2009 to create a publicly available database - facebase.org - to study how faces develop and the dysfunctions that underlie craniofacial malformations. It's been updated to reflect more data and new methods.
The FaceBase website home page is shown here.
As bioinformatics techniques have advanced and expanded, the amount of data that has been generated has been tremendous. However, it’s becoming increasingly apparent to researchers that in many cases, it’s the connections between those observations that provide the critical insight into the physiology that underlies the complex processes of development.

The National Institute of Dental and Craniofacial Research (NIDCR) established the FaceBase Consortium with the goals of creating comprehensive resources to empower and foster collaboration in the research community, taking advantage of high-throughput technology, and facilitating hypothesis-driven research to take scientific discovery from the bench to the bedside. The video below shows the opening remarks from the annual FaceBase meeting in 2016.
Since the inception of FaceBase, the NIDCR has enabled eleven peer-reviewed research projects; one of those projects served as ‘the Hub’ or central project that functioned to coordinate and integrate data. The remaining ten projects were ‘spoke’ projects that would flesh out the database with both information generated from research and technological development.

Those projects have turned into around 600 datasets on midface development in humans and animals, which are now part of facebase.org and openly accessible to the public. Over 100 publications have now referenced these resources. The NIDCR has also funded three projects that will perform secondary analysis of FaceBase datasets, using them to investigate human craniofacial conditions and their corresponding animal models.
The architecture of the consortium is illustrated here. / Credit: Developmental Cell
In 2014, FaceBase 2 was launched with another set of Hub and spoke projects. This time, the scope of the consortium was expanded to include the craniofacial region beyond the palate and midface. The aim of the project remains generally the same – the acceleration of research into craniofacial development through easy accessibility of a massive and diverse stew of resources. No one lab would be able to create this pool of data on their own. As the repository of information grows, it can be applied in more ways; data from several animal models provides an evolutionary and a translational context. Another video from their 2016 meeting is shown below, this time discussing genomic and transgenic resources.
There are many kinds of data in the FaceBase projects. Genome-wide association studies, anatomical atlases, detailed to global gene expression patterns, software tools, imaging modalities and transcriptional information from the course of development from embryonic to postnatal, is included.  The Hub also provides users with flexible and interactive ways to interrogate the information.

A new publication in Developmental Cell has highlighted the various new projects in the latest iteration of FaceBase. The authors comment that they hope to promote data sharing in the scientific community while upholding strong standards of intergrity and transparency. They also note the importance of taking time to evaluate the consortium and ensure that it fulfills its mandate to improve the lives of patients through collaborative efforts.

Sources: FaceBase.org, Developmental Cell
 
About the Author
  • Experienced research scientist and technical expert with authorships on 28 peer-reviewed publications, traveler to over 60 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
MAR 17, 2020
Genetics & Genomics
MAR 17, 2020
Targeting RNA With CRISPR
Researchers screened thousands of target molecules to find the most effective targets, and have made their data openly a ...
MAR 18, 2020
Cell & Molecular Biology
MAR 18, 2020
Researchers Devise a Way to Model Membraneless Organelles
Like mixing oil and water, cells use phase separation to organize and separate their contents.
APR 04, 2020
Cancer
APR 04, 2020
Unique Cancer Mutation Hijacks Nearby Signaling Pathway
  In cancer, tyrosine kinase mutations are quite common. MET is one such example that normally binds its native lig ...
APR 09, 2020
Cancer
APR 09, 2020
The Unexpected Anti-Cancer Effects of the Human Telomerase
The research to find effective treatments and diagnosing tools in the fight against cancer has led to a thorough investi ...
APR 13, 2020
Neuroscience
APR 13, 2020
The Memory Cells that Help Us Interpret Different Situations
Neuroscientists from MIT have identified cell populations that encode different parts of an overall experience. Like the ...
MAY 24, 2020
Cell & Molecular Biology
MAY 24, 2020
Common Chemicals May Contribute to Obesity
Several explanations have been proposed to answer the question of why obesity has been on the rise for many years in the ...
Loading Comments...