NOV 07, 2016 05:54 PM PST

Blood Vessels Regulate Growth of the Rodent Brain

WRITTEN BY: Carmen Leitch
New neurons in the brain of adult rodents are regulated by the blood vessels that are associated with them. Research that was recently published in the Proceedings of the National Academy of Scientists by researchers at University College London (UCL) has demonstrated that blood vessels are able to increase the amount of neural stem cells that an organism has, using mice as a model. This work could help improve the development of therapeutics that use stem cells as a way to regenerate parts of the nervous system that have become damaged or are diseased.
 
Multipotential Human Neural Progenitor Cells / Credit: NIH
 
Neural stem cells of the developing rodent brain perform self-renewal and also produce cells that are destined to become neurons. The stem cells receive direction as to how frequently they reproduce and what cell type they create. The signals that send those directions have been unclear, however. This new work shows how important blood vessels are in this process.
 
"We found that blood vessels play a vital role in telling neural stem cells when and how to reproduce," explained the lead author of the work, Mathew Tata of the UCL Institute of Ophthalmology. "We examined neural stem cell behaviour in the brainstem of mice lacking the blood vessel protein NRP1, because this part of the brain is particularly important to control fundamental processes such as breathing and heart rate.”
 
The researchers used genetically altered mice in their work. “Preventing blood vessel growth in the neurogenic areas of the brainstem interfered with normal neuron production, causing neural stem cells to lose their ability to reproduce. As a result the stem cells disappeared from the brainstem before its growth was complete, so mice lacking NRP1 ended up with smaller brainstems," said Tata.
 
The investigators have shown that blood vessels play critical roles not only in supplying the developing brain with oxygen, but also in stem cell signaling and how stem cells are regulated.
 
"Blood vessels are best known for their important function in supplying oxygen and nutrients to the brain," said senior author Christiana Ruhrberg, also of the UCL Institute of Ophthalmology. "However, the most intriguing finding of this study was that blood vessels did not regulate neural stem cell behavior in the brainstem simply through their role in brain oxygenation or keeping brain tissue healthy. We found that blood vessels also provide important signals that allow stem cells to reproduce for a longer period of time, before they permanently become nerve cells that cannot multiply."
 
Sources: AAAS/Eurekalert! via UCL News, PNAS
 
About the Author
  • Experienced research scientist and technical expert with authorships on 28 peer-reviewed publications, traveler to over 60 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
OCT 20, 2019
Technology
OCT 20, 2019
Bioprinting Complex Tissues
Tissue engineering is a quickly growing field that involves the development of artificial organs and tissues that can be utilized to test the efficacy of d...
OCT 20, 2019
Drug Discovery & Development
OCT 20, 2019
The Three Drugs that Reverse Biological Aging
In the last 100 years, life expectancy in the US has risen from 55 years until 79 (Roser: 2019). And with the continuous development of medicine and scie...
OCT 20, 2019
Genetics & Genomics
OCT 20, 2019
Genetic Cause for Tumor Progression
Researchers from the University of Delaware (UDEL), Harvard Medical School (HMS) and University of California, Los Angeles (UCLA), have discovered a ribonu...
OCT 20, 2019
Genetics & Genomics
OCT 20, 2019
A DNA 'Stitch' as a Therapy for Duchenne Muscular Dystrophy
DMD is a genetic disorder that causes degeneration in muscles. Now there may be a treatment for as many as 47% of patients....
OCT 20, 2019
Neuroscience
OCT 20, 2019
Extreme athletic training tires out the brain, impairs decision-making
Excessive athletic training does some wear and tear on the body; but according to new research, it can also make the brain tired, leading to poor decision-making. In a paper recently publish...
OCT 20, 2019
Immunology
OCT 20, 2019
Coffee Bean Extracts for Fat-induced Inflammation
One man’s coffee trash is another man’s solution for addressing chronic inflammation. A new Food and Chemical Toxicology study illustrates the ...
Loading Comments...