OCT 16, 2018 10:37 PM PDT

Anti-Venomous Plant Compound

WRITTEN BY: Nouran Amin

According to a study published in PLOS Neglected Tropical Diseases, researchers at the Institute Butantan, São Paulo, Brazil, have discovered a flavonoid found in plants to be effective in acting as antivenom compound from the South American pit viper Bothrops jaraca.

The viper is most commonly found northern Argentina, southern Brazil and northeastern Paraguay. It is an abundant species and the large cause of snakebites. Their venom is composed of a mixture of complex proteins that disrupt chemical reactions inside cells.

Being bitten by the snake, can lead to site swelling, blistering, severe hypotension and systemic bleeding from the skin, nose, and gums--eventually leading to shock, intracranial hemorrhage, or renal failure. More than often, the venom of the viper causes proteolytic, coagulant and hemorrhagic effects. Uniquely, these properties are based on a peptide found in their venom which is presently being used for drug development in the treatment of heart failure and hypertension.

Image via RisingKashmir.com

The flavonoid identified is called ‘rutin’ which can protect envenomed mice from bleeding and inflammation complications. Current anti-venoms can treat the major issues arising from a snake bite however, it cannot treat common saucer implications of the bite including bleeding.

Chemical Structure of Rutin. Image via 'Rutin' from Wikipedia

Existing anti-venoms can treat the major effects of the snake bites however, there are no known therapies for common secondary complications, such as the inability to stop the bleeding.

Results of the research were derived from studies on mouse models injected with both venom and rutin. The mice were than further analyzed for the physiological triggers of venom to better understand the effects rutin on pathophysiological events triggered by the venom. The research findings ‘indicates that rutin has a great potential as an ancillary drug in concert with antivenom therapy to treat snakebites, particularly in countries where antivenom availability is scarce.’

 

Source: Drug Target Review

About the Author
  • Nouran earned her BS and MS in Biology at IUPUI and currently shares her love of science by teaching. She enjoys writing on various topics as well including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
NOV 25, 2019
Drug Discovery & Development
NOV 25, 2019
Discovery of mechanism behind Alexander disease may lead to enhanced drug development
Researchers have long known that the cause behind Alexander disease is a genetic culprit—mainly a mutation leading to the production of a defective p...
DEC 12, 2019
Drug Discovery & Development
DEC 12, 2019
Probiotics Treat Alcohol-Induced Liver Injury
Alcoholic liver injury is caused by overconsumption of alcohol, something that can lead to serious diseases such as liver steatosis, liver cirrhosis and li...
DEC 19, 2019
Drug Discovery & Development
DEC 19, 2019
Upcoming Psychedelic Cure for Addiction Derived from African Shrub
Every year, almost 70,000 people die from an overdose in the US. Now, a company called MindMed is testing a compound derived from ibogaine, a West African ...
DEC 23, 2019
Drug Discovery & Development
DEC 23, 2019
Novel Drug for Treating Insomnia
The U.S. Food and Drug Administration (FDA) has approved DAYVIGO™ (lemborexant) in 5 mg and 10 mg for the treatment of insomnia among adult patients ...
JAN 15, 2020
Cancer
JAN 15, 2020
Hope for patients with AML
Research published recently in the medical journal EMBO Molecular Medicine brings hope for leukemia patients with a report that a common and cheap drug may...
FEB 03, 2020
Drug Discovery & Development
FEB 03, 2020
HIV Viral Structures Improve Therapeutics
Researchers have recently discovered how a powerful class of HIV drugs bind to a key piece of HIV machinery. Their findings, for the first time, shows how ...
Loading Comments...