JAN 24, 2019 10:06 AM PST

Drug Slows Cancer's Circadian Clock

WRITTEN BY: Nouran Amin

According to a study done on human kidney cancer cells and acute myeloid leukemia cells in mice, a compound was examined to halt the cancerous growth by stunting the cell’s biological clock. The compound is named GO289 and works by targeting an enzyme that slows down the cell's circadian rhythm. Since disrupting the essential factors that make up the circadian rhythm can negatively impact health—the same applies for the circadian clock of cells which has concerned researchers that a compound like GO289 might affect healthy cells.

Learn more about circadian rhythms:

Essentially, the drug-protein interaction disrupts the functions of other proteins that are important for cell growth and survival. "In some cancers, the disease takes over the circadian clock mechanism and uses it for the evil purpose of helping itself grow," says Steve Kay, director of convergent biosciences at the USC Michelson Center and USC Provost Professor of Neurology, Biomedical Engineering and Biological Sciences. "With GO289, we can interfere with those processes and stop the cancer from growing."

The photograph shows an enlarged view of human bone cancer cells, which stopped growing when a drug molecule, GO289, jammed their circadian rhythm.

Credit: USC Michelson Center for Convergent Bioscience via ScienceDaily

However, the researchers wanted to see if GO289 hindered other cancers in anyway. They tested GO289 on human bone cancer cells and was examined to inhibit an enzyme named CK2--slowing down the tumors' circadian clock. They concluded that GO289 inhibited cancer cell metabolism and other circadian-related functions that normally would enable the cancer to metastasize.

Findings of the study were published in Science Advances and seeks to bring life to the study of circadian rhythms as a method of fight against cancer. "This could become an effective new weapon that kills cancer," says Kay.

Source: USC Dornsife

About the Author
  • Nouran earned her BS and MS in Biology at IUPUI and currently shares her love of science by teaching. She enjoys writing on various topics as well including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
SEP 13, 2020
Drug Discovery & Development
Scientists Find Way to Reduce Inflammation from Vaccines
SEP 13, 2020
Scientists Find Way to Reduce Inflammation from Vaccines
Researchers from the University of Chicago have found a new way to reduce vaccine-related inflammation from adjuvants, a ...
SEP 21, 2020
Microbiology
A Fast, Cheap Way to See if Two Antibiotics Work Together
SEP 21, 2020
A Fast, Cheap Way to See if Two Antibiotics Work Together
When a person has a bacterial infection, doctors can prescribe antibiotics. Some antibiotics combos can work better than ...
OCT 01, 2020
Cancer
Understanding in vivo Metabolomics: C13 Isotope Studies
OCT 01, 2020
Understanding in vivo Metabolomics: C13 Isotope Studies
One key to understanding cancer metabolomics lies in the ability to accurately replicate the natural environment of the ...
OCT 05, 2020
Drug Discovery & Development
Fecal Transplants Could Restore Cognitive Function in the Elderly
OCT 05, 2020
Fecal Transplants Could Restore Cognitive Function in the Elderly
An international team of researchers has found that fecal transplants could one day be used to restore cognitive functio ...
OCT 12, 2020
Microbiology
Researchers May Have Found a Way to Cure Rotavirus Infections
OCT 12, 2020
Researchers May Have Found a Way to Cure Rotavirus Infections
Rotaviruses are very contagious. They are the most common cause of diarrhea in children and are estimated to cause about ...
NOV 02, 2020
Drug Discovery & Development
Type 2 Diabetic Drug Combo Proves Effective
NOV 02, 2020
Type 2 Diabetic Drug Combo Proves Effective
A common first-line therapeutic for type 2 diabetes is the metformin drug used to stabilize blood glucose levels. Althou ...
Loading Comments...