JUN 10, 2019 12:10 PM PDT

Tart Cherry and Pain Management in Breast Cancer Patients

WRITTEN BY: Nouran Amin

In patients with non-metastatic breast cancer, treated with aromatase inhibitors, tart cherry was found to reduce the musculoskeletal effects of the drug. The findings were based on a clinical trial by researchers at Marshall University Joan C. Edwards School of Medicine and Edwards Comprehensive Cancer Center.

"The flavonoids and anthocyanins in tart cherry have anti-inflammatory properties and may be playing a role in reducing the side effects of joint pain and muscles aches, although etiology of aromatase-induced arthralgias remain unclear at this time," said principal investigator Maria Tria Tirona, M.D., professor of hematology-oncology at the Marshall University Joan C. Edwards School of Medicine and director of medical oncology at Edwards Comprehensive Cancer Center. "There was a statistically significant difference in the pain levels experienced by patients in the group that received the tart cherry concentrate compared to the placebo group."

Currently, aromatase inhibitors (AIs) therapeutics are the standard treatment option for hormone receptor-positive breast cancer in postmenopausal women. The drug can prevent reemergence of the disease by blocking the activity of aromatase, an enzyme that is responsible for converting androgens to estrogens. However, an estimated half of all patients treated with AIs will suffer from joint and muscle pain. That particular pain is known as aromatase inhibitor induced arthralgia and at times can often be so painful and debilitating that it leads to patients to stop treatmetns earlyleading to patients stopping treatments.

Learn more about aromatase inhibitors (AIs):

But, in the randomized, double-blind trial of 60 participants, the consumption of 1 ounce of tart cherry concentrate in 8 ounces of water daily for six weeks with a placebo group in women was compared with stage 1, 2 or 3 non-metastatic breast cancer.

Patients were required to document their pain intensity at the beginning of the trial, weekly and at study completion. Upon completion, 34.7% of patients reported a mean decrease in pain compared to just 1.4% in the placebo group.

Source: Joan C. Edwards School of Medicine

 

About the Author
  • Nouran enjoys writing on various topics including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
DEC 12, 2019
Technology
DEC 12, 2019
New Encapsulation Technology
Research at the University of Waterloo has concluded new encapsulation technology that can offer an inexpensive, and effective method for coating liquid me...
DEC 12, 2019
Drug Discovery & Development
DEC 12, 2019
How Fluorescent Probes Can Enhance Drug Delivery
Researchers at Cornell University are working on improving the trial-and-error process that is implicated in finding effective molecules for drug delivery....
DEC 12, 2019
Drug Discovery & Development
DEC 12, 2019
Gene Variant Could Be a Therapeutic Target For Alzheimer Disease
A variation in genetics for an individual at high-risk for Alzheimer development has defied the odds for being dementia-free way beyond anticipated. The in...
DEC 12, 2019
Genetics & Genomics
DEC 12, 2019
New Way to Determine What Our Genes Do
Geneticists at the University of Virginia (UVA) School of Medicine have developed a new way to determine what our genes do. This will not only allow scient...
DEC 12, 2019
Drug Discovery & Development
DEC 12, 2019
The Fight Against Lethal Childhood Brain Cancers
Scientists used studies on cell and animal models to reveal insights into lethal childhood brain cancers and find promising drug therapeutics. The deadly c...
DEC 12, 2019
Drug Discovery & Development
DEC 12, 2019
Could the diabetic drug 'metformin' extend a healthy lifespan?
The most commonly prescribed diabetic medication for the Type 2 condition is ‘Metformin’—a drug with a mysterious mechanism of action but...
Loading Comments...