JUN 17, 2019 7:59 AM PDT

Promising Hypertension Drug for Alzheimer Disease

WRITTEN BY: Nouran Amin

In a study led by the American Heart Association, the blood pressure drug nilvadipine (a calcium channel blocker) was found to increase blood flow to the brains memory and learning center in individuals with Alzheimer's disease without adverse effects to other regions of the brain. The study was published in the journal Hypertension and indicates that a decrease in cerebral blood flow in patients with Alzheimer's can be reversed in some regions.

Alzheimer disease is a form of dementia with a risk that increases with age. Causes for Alzheimer disease still remain unknown but earlier studies have shown that blood flow to the brain declines in the early stages of Alzheimer disease. Other studies implied that possible high blood pressure treatment may reduce the risk of dementia possibly because of the beneficial effects on brain blood flow.

"This high blood pressure treatment holds promise as it doesn't appear to decrease blood flow to the brain, which could cause more harm than benefit," said study lead author Jurgen Claassen, M.D., Ph.D., associate professor at Radboud University Medical Center in Nijmegen, the Netherlands. "Even though no medical treatment is without risk, getting treatment for high blood pressure could be important to maintain brain health in patients with Alzheimer's disease."

Learn more about Alzheimer Disease:

 

 

"In the future, we need to find out whether the improvement in blood flow, especially in the hippocampus, can be used as a supportive treatment to slow down progression of Alzheimer's disease, especially in earlier stages of disease," Claassen said.

The study was the first to utilize MRI technique to observe the effects of treatment on cerebral blood flow.

Source: American Heart Association

About the Author
  • Nouran is a scientist, educator, and life-long learner with a passion for making science more communicable. When not busy in the lab isolating blood macrophages, she enjoys writing on various STEM topics.
You May Also Like
JAN 07, 2021
Drug Discovery & Development
Novel Drug To Treat Osteoporosis
JAN 07, 2021
Novel Drug To Treat Osteoporosis
A novel drug to treat osteoporosis comes with fewer side effects and may potentially be a new option for patients. The s ...
FEB 26, 2021
Microbiology
Good Bacteria Fights Bad Bacteria in a Clinical Trial
FEB 26, 2021
Good Bacteria Fights Bad Bacteria in a Clinical Trial
Eczema is a skin condition that causes a chronic, itchy rash. The most common form of the disorder, atopic dermatitis, i ...
FEB 22, 2021
Drug Discovery & Development
Screening Macrocyclic Peptides
FEB 22, 2021
Screening Macrocyclic Peptides
Macrocyclic peptides are promising for pharmaceuticals for cancer—however, screening for them is challenging. Find ...
APR 03, 2021
Drug Discovery & Development
Why Are Some Cancer Therapeutics Ineffective?
APR 03, 2021
Why Are Some Cancer Therapeutics Ineffective?
Why don’t some cancer therapeutics not work in humans when they were successful in mice? The answer to this questi ...
APR 21, 2021
Drug Discovery & Development
Dietary Supplement Successfully Treats Mice with Schizophrenia
APR 21, 2021
Dietary Supplement Successfully Treats Mice with Schizophrenia
Researchers from the University of Tokyo have found that betaine, a dietary supplement found in sugar beets, reduces beh ...
APR 24, 2021
Drug Discovery & Development
Lithium Treats Intellectual Disabilities in Mice
APR 24, 2021
Lithium Treats Intellectual Disabilities in Mice
Mouse models of Bardet-Biedl Syndrome (BBS) have a challenge with learning as a result of dysfunctional neuronal systems ...
Loading Comments...