JUL 03, 2019 7:17 AM PDT

Controlling The Release of Drug Components Using Artificial DNA

WRITTEN BY: Nouran Amin

Studies carried out at the Technical University of Munich (TUM) can allow nanapoarticles to be released in pre-defined sequence at specified times. Using a combination of hydrogels and artificial DNA, the process may advance the field of therapeutics for drugs that contain several active ingredients.

More patients are now placed on several different medications with the necessity of taking these medicines at correct intervals—such requirement often increases the risk of skipping critical doses or completely forgetting to the medication altogether

“For example, an ointment applied to a surgical incision could release pain medication first, followed by an anti-inflammatory drug and then a drug to reduce swelling," explains Oliver Lieleg, a professor of biomechanics and a member of the Munich School of BioEngineering at TUM. "Ointments or creams releasing their active ingredients with a time delay are not new in themselves.”

The study utilized a spectroscopic tool to track the exit of nanometer-sized silver, iron oxide and gold particles embedded in a hydrogel. They examined particles that are similar to the motion characteristics of the hydrogel which is used for the transport of real active ingredients.

Technical University of Munich: This chart shows a simplified version of the new approach which consist of one active ingredient at a time. Image: Ceren Kimna / TUM

"The consistency of ointments makes them the most obvious solution for a hydrogel-based approach. However, this principle also has the potential to be used in tablets that could release several effective ingredients in the body in a specific order," says Professor Lieleg.

The unique ingredient controlling the nanoparticles is artificial DNA.

Learn more about the general creation of artificial DNA:

DNA carries our genetic information, however, in recent years researchers have been exploiting the combination of DNA fragments.

Technical University of Munich: Prof. Oliver Lieleg and PhD student Ceren Kimna use balls and pipe cleaners in different colors to visualize how nanoparticles can be bound together by DNA fragments. Such connections may become the basis of drugs that release their active ingredients in sequence. Image: Uli Benz / TUM

In the study, silver particles were bound by DNA fragments which were so large that affected their mobility in the hydrogel. It wasn’t until a saline solution was added that the silver particles were free from the DNA.

"Because the saline solution has approximately the same salinity as the human body, we were able to simulate conditions where the active ingredients would not be released until the medication is applied," says doctoral candidate, Ceren Kimna.

Source: Technical University of Munich

About the Author
  • Nouran earned her BS and MS in Biology at IUPUI and currently shares her love of science by teaching. She enjoys writing on various topics as well including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
APR 22, 2020
Drug Discovery & Development
APR 22, 2020
Using Colors To Track The Spread of Drug Particles
Forensic scientists from the National Institute of Standards and Technology (NIST) are relying on color to see the sprea ...
MAY 08, 2020
Drug Discovery & Development
MAY 08, 2020
Cholesterol Drugs May Boost Healthy Gut Bacteria in Obese People
While statins have long been known for their efficacy in treating high cholesterol, until recently, there was no evidenc ...
MAY 02, 2020
Drug Discovery & Development
MAY 02, 2020
Glioblastoma Treatment Using Schizophrenic Drug Plus Radiation
A therapeutic used for the treatment of schizophrenia could be a gateway for targeting glioblastoma, one of the deadlies ...
MAY 03, 2020
Drug Discovery & Development
MAY 03, 2020
Hydroxychloroquine: The Controversial Use
COVID-19 was declared a public health threat on January 30th and since then it took the world by a storm with more than ...
MAY 13, 2020
Drug Discovery & Development
MAY 13, 2020
Fecal Transplant Helps Fight off Antibiotic Resistance
Fecal transplants work by transporting fecal matter from healthy donors to those who are less healthy. Now, a study has ...
MAY 23, 2020
Chemistry & Physics
MAY 23, 2020
Improving the understanding of GPCRs functioning
New research reported in Current Opinion in Structural Biology combines structural and spectroscopic approaches to garne ...
Loading Comments...