JUL 03, 2019 6:36 AM PDT

Common Anticonvulsant Drug May Counteract Inflammation

WRITTEN BY: Nouran Amin

Sepsis is a serious medical condition that results from inflammation in the body and can cause fatal multi-organ dysfunction. The inflammation is usually triggered from a chromosomal protein called high-mobility group box 1 (HMGB1) that is secreted from immune or dying cells. Current treatments methods to counteract the inflammation lacks efficacy however, a common anticonvulsant and vasodilating drug called papaverine, discovered recently by scientists through a computer software-based docking study, may provide a strong therapeutic method.

Learn more about sepsis:

"Our research group has been trying to identify compounds, preferably based on existing drugs, that block the binding of irritants to cellular receptors,” says senior researcher, Professor Sei-ichi Tanuma from Tokyo University of Science (TUS). “We want to find novel drugs to treat inflammation-based conditions.”

Supposedly, papeverine can effectively counteract the inflammation in septic conditions by inhibiting the binding of HMGB1 to its receptor—known as RAGE. Findings of the study published in Biochemical and Biophysical Research Communications describes a novel approach involving the utilization of a computer software program known as "COSMOS” to develop a small protein that mimics the RAGE-binding domain of HMGB1. Results indicated that the designed protein effectively mimicked the binding domain and "competitively inhibited" the HMGB1-RAGE interaction. Using data generated from the DrugBank Library, they concluded that papaverine was structurally similar to the protein they designed.

"This in silico drug design approach, to find novel effects of papaverine, is a unique strategy employed for the first time only by TUS researchers,” says Professor Tanuma.

Laboratory studies have shown that papaverine successfully reduced death rates among model mice.

"Drug repositioning using the in silico drug discovery approach used in our research can repurpose existing drugs into novel therapeutic agents. Also, because the cost of 'designing' a novel drug is saved, such approaches can also radically reduce the cost of medical treatment. The next step is to understand the degree to which papaverine blocks HMGB1-RAGE interaction in the human body. We are now trying to optimize the structure of papaverine to design a more 'effective' drug for the future."

Source: Science Daily

About the Author
  • Nouran earned her BS and MS in Biology at IUPUI and currently shares her love of science by teaching. She enjoys writing on various topics as well including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
SEP 21, 2020
Microbiology
A Fast, Cheap Way to See if Two Antibiotics Work Together
SEP 21, 2020
A Fast, Cheap Way to See if Two Antibiotics Work Together
When a person has a bacterial infection, doctors can prescribe antibiotics. Some antibiotics combos can work better than ...
SEP 20, 2020
Drug Discovery & Development
New Drug Shows Promise in Treating Advanced COVID-19
SEP 20, 2020
New Drug Shows Promise in Treating Advanced COVID-19
As the COVID-19 pandemic rages on, the search for drugs to combat the virus is ongoing. Now, scientists have found that ...
OCT 03, 2020
Cannabis Sciences
Cannabis Compound Prevents Colon Cancer in Mice
OCT 03, 2020
Cannabis Compound Prevents Colon Cancer in Mice
Second only to skin cancer, colon cancer is the most common cancer diagnosed in both men and women in the US. Now, resea ...
OCT 01, 2020
Drug Discovery & Development
Antidepressants Treats Lazy Eye
OCT 01, 2020
Antidepressants Treats Lazy Eye
A study published in Current Biology revealed how a therapeutic used as an antidepressant and for managing pain could tr ...
NOV 01, 2020
Cannabis Sciences
Can Cannabis Treat ALS?
NOV 01, 2020
Can Cannabis Treat ALS?
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative illness that damages motor neurons and leads to progressive m ...
NOV 06, 2020
Drug Discovery & Development
New Vaccine Shows Promise for Herpes
NOV 06, 2020
New Vaccine Shows Promise for Herpes
The World Health Organization estimates that over 500 million people have Herpes Simplex Virus Type 2 (HSV-2), a sexuall ...
Loading Comments...