OCT 22, 2019 9:44 PM PDT

Common Therapeutic Can Treat Bleeding Associated with Traumatic Brain Injury

WRITTEN BY: Nouran Amin

An inexpensive and accessible drug was found to reduce rates of mortality associated with traumatic brain injury (TBI) patients by 20%. TBI is a major cause of death and disability worldwide however, the effectiveness of the drug, known as tranexamic acid (TXA), is highly dependent on depending on the severity of the head injury. The findings of the study were published in The Lancet and explains how TXA can block the bleeding into the brain by stopping the breakdown of the blood clot and saving hundreds of thousands of lives.

Learn more about the clinical trial, CRASH-3 (Clinical Randomisation of an Antifbrinolytic in Significant Head Injury), involving TXA:

 

“We already know that rapid administration of tranexamic acid can save lives in patients with life threatening bleeding in the chest or abdomen such as we often see in victims of traffic crashes, shootings or stabbings. This hugely exciting new result shows that early treatment with TXA also cuts deaths from head injury. It’s an important breakthrough and the first neuroprotective drug for patients with head injury,” states Ian Roberts, Professor of Clinical Trials at the London School of Hygiene & Tropical Medicine, who co-led the study.

“Traumatic brain injury can happen to anyone at any time, whether it’s through an incident like a car crash or simply falling down the stairs. We believe that if our findings are widely implemented they will boost the chances of people surviving head injuries in both high income and low income countries around the world.”

A common complication of TBI is bleeding in the brain as a result of tearing in the blood vessels. Early treatment with TXA is critical to prevent the severity of bleeding—but, still cannot undo the overall damage to the brain and head regions.

CT scan observing an enlarging epidural. (Image Credit: LSHTM.AC.UK)

“This is a landmark study. After decades of research and many unsuccessful attempts, this is the first ever clinical trial to show that a drug can reduce mortality after traumatic brain injury. Not only do we think this could save hundreds of thousands of lives worldwide, but it will no doubt renew the enthusiasm for drug discovery research for this devastating condition,” says Dr. Antoni Belli, a neurosurgeon and Professor of Trauma Neurosurgery at the University of Birmingham.

Watch this video below to learn more about the possibility of having TXA as a treatment measure to reduce death associated with head injuries:

“Treating traumatic brain injury is extremely challenging with very few treatment options available for patients. Thanks to these latest results, which are applicable to patients with head injuries of any cause and of all demographics, clinicians now have a potentially powerful new treatment available to them,” says Dr. Ben Bloom, a Consultant in Emergency Medicine at Barts Health NHS Trust.

Source: Science Daily, London School of Hygiene and Tropical Medicine

About the Author
  • Nouran earned her BS and MS in Biology at IUPUI and currently shares her love of science by teaching. She enjoys writing on various topics as well including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
DEC 25, 2019
Drug Discovery & Development
DEC 25, 2019
New Drug to Make Breast Cancer Treatment More Affordable
The US Food and Drug Administration has granted accelerated approval to new breast cancer drug, trastuzumab deruxtecan. The drug’s increasing recogni...
JAN 16, 2020
Drug Discovery & Development
JAN 16, 2020
Fatty Acid Supplement Repairs Brain After Stroke in Mice
Researchers have found that supplements containing short chain fatty acids (SCFAs) may be able to help the brain recover from having a stroke. This comes a...
JAN 21, 2020
Cell & Molecular Biology
JAN 21, 2020
Repurposing Existing Drugs to Treat Cancer
Drugs have to be rigorously tested before they can be offered to patients, so it can be much easier to find more than one application for a medication....
JAN 18, 2020
Drug Discovery & Development
JAN 18, 2020
Drug Combo Targets Osteoarthritis
Individuals suffering from osteoarthritis often face challenges of limited treatment options mainly pain relievers or joint replacement surgery. However, s...
FEB 26, 2020
Microbiology
FEB 26, 2020
NIAID Tests Remdesivir as a Treatment for COVID-19
A case of coronavirus has now occured in the US in someone without a known link to an infected person or travel....
FEB 27, 2020
Drug Discovery & Development
FEB 27, 2020
New Drug Shows Promise in Treating Chronic Cough
Between 4% and 10% of adults around the world have an unexplainable chronic cough that has lasted for over 8 weeks. Although no treatments are currently av...
Loading Comments...