OCT 22, 2019 10:08 PM PDT

Metformin Offers No Muscle Mass Gain for Older Adults

WRITTEN BY: Nouran Amin

A clinical trial initiated by Researchers at the University of Kentucky began a clinical study to address the long-held hypothesis that metformin, the diabetes drug, can help physical active seniors to gain muscle mass. The findings of the double-blind trial indicated that older adults who took metformin while had smaller gains of muscle mass than the placebo group. Results were published in the journal Aging Cell.

Learn more about metformin:

"Because metformin has anti-inflammatory properties, we thought it would be a logical candidate to study," said Charlotte Peterson, Ph.D., professor in the UK College of Health Sciences and director of the Center for Muscle Biology.

Although studies show that progressive resistance exercises can help older adults build muscle mass, this is highly dependent the presence of chronic inflammation.

"In older adults (age 65 and up) who have lost significant muscle mass and function over prior decades, we thought metformin might combat muscle inflammation and thereby boost the muscle regrowth response to resistance training," said Marcas Bamman, Ph.D., professor in the UAB Department of Cell, Developmental and Integrative Biology and director of the UAB Center for Exercise Medicine. "Instead, metformin impaired blunted the adaptations such that the placebo group experienced greater increases in muscle mass and muscle quality than the metformin group."

About half of the clinical study participants took 1700 mg of metformin every day, while the other half took a placebo. In two groups, they completed 14 weeks of resistance training and underwent thigh CT scans, DXA measurement, and a muscle biopsy.

"DXA and CT scans showed that the placebo group had greater gains in overall lean muscle mass and thigh muscle mass," said Peterson. "CT scans and analysis of the biopsy also allowed us to determine that the quality of the muscle improved in the control group over the metformin group."

Source: Science Daily

About the Author
  • Nouran enjoys writing on various topics including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
NOV 14, 2019
Drug Discovery & Development
NOV 14, 2019
Transplanted Brain Stem Cells Survive Without Anti-Rejection Drugs
Researchers at Johns Hopkins Medicine have successfully transplanted brain cells without the need of immune-suppressing drugs. Findings of the study were p...
NOV 14, 2019
Drug Discovery & Development
NOV 14, 2019
Injectable Implant Drug Shows Promise for HIV Treatment
In a study published in Nature Communications, alternative treatment was shown to have promising results for HIV as opposed to a daily pill regimen. Scient...
NOV 14, 2019
Drug Discovery & Development
NOV 14, 2019
Drug Increases Survival Rates for Heart Failure Patients
Scientists have demonstrated in preclinical studies that a drug called ‘Aliskiren’ works by inhibiting the activity of an enzyme involved in bl...
NOV 14, 2019
Drug Discovery & Development
NOV 14, 2019
Nanomesh Development Advances Drug Delivery's Fight Against Antibiotic-Resistance
As concern over medication-resistant bacteria grows, researchers at Flinders University have now fabricated nanomeshes as an effective drug delivery method...
NOV 14, 2019
Cancer
NOV 14, 2019
Using senolytics to treat cancer
New research published in Nature Metabolism proposes using an already existing drug – a cardiac glycoside called ouabain – as a senolytic to ki...
NOV 14, 2019
Drug Discovery & Development
NOV 14, 2019
Developing Animal-Free Neurotoxin Testing
The need to assess a group of deadly neurotoxins without turning to animal-testing may soon be a possibility. A new animal-free testing technique was recen...
Loading Comments...