NOV 04, 2019 10:26 AM PST

How Fluorescent Probes Can Enhance Drug Delivery

WRITTEN BY: Nouran Amin

Researchers at Cornell University are working on improving the trial-and-error process that is implicated in finding effective molecules for drug delivery. Specifically, researchers have developed a technique that employs florescent probes that enhances the drug delivery method by giving scientists a unique look inside cells. Study authors are hopeful that their technique can advance through pharmaceutical partnerships.

Learn more about drug delivery systems:

 

“For the biomolecular engineers and companies that have a target in mind, we can … make the drug discovery process that much faster because we now know something about how long it’s going to take to release the drug,” says research team leader, Chris Alabi.

Current drug delivery systems control how therapeutics are released inside the body which involves how a particular molecule that ‘links’ to another in the body, like an antibody on cancer cells. “Right now, pharmaceutical companies make a ton of linkers and then see which functions best for a particular application by having to test each one. It’s a shotgun approach,” said Alabi, am associate professor of chemical and biomolecular engineering. “With our technique, they can now make an informed decision based on actual intracellular numbers, before they put the drug system together.”

The researchers tested their fluorescent probes to measure the rate at which linkers successfully release drugs in living cells. Findings were published in the research a paper “Responsive Antibody Conjugates Enable Quantitative Determination of Intracellular Bond Degradation Rate,” seen in the journal Cell Chemical Biology.

Image retrieved via Cornell University (Credit)

“Once we know what the timing is for different linker bonds and cell processes, then we can say, ‘OK, for drug A connected to antibody B, this is how long it will take, so if we want to treat disease C, we should use this linker,’” Alabi said. “The probes can also be used by chemical biologists to learn more about intracellular processes, such as the specific agents responsible for cleaving linkers.”

Source: Cornell University

About the Author
  • Nouran earned her BS and MS in Biology at IUPUI and currently shares her love of science by teaching. She enjoys writing on various topics as well including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
APR 21, 2020
Neuroscience
APR 21, 2020
Considerations for Lab Managers in Choosing a Microplate Reader
In today's high-tech, digitized laboratory environments, nobody pays very much attention to the humble plastic micro ...
APR 17, 2020
Chemistry & Physics
APR 17, 2020
Fish Tank Chemicals Aren't COVID-19 Medication, Says FDA
While the medical community is scrambling to find the proper medications for Sars-CoV-02 infection, a significant portio ...
APR 22, 2020
Drug Discovery & Development
APR 22, 2020
Preventing Blindness in Premature Births
The premature birth of infants places them at risk for blindness because of retinopathy of prematurity (ROP). To prevent ...
MAY 11, 2020
Cancer
MAY 11, 2020
Using Deep Learning to Diagnose Breast Cancer Sub-Types
Cancer and computer programming may not sound like two things that go together. However, advanced programming techniques ...
MAY 25, 2020
Drug Discovery & Development
MAY 25, 2020
Potential Targets for Alcohol Induced Liver Disease
Alcohol-related liver disease (ALD) is a fatal condition targeting more than 150 million people. Part of what makes it d ...
MAY 29, 2020
Genetics & Genomics
MAY 29, 2020
Advances in Our Understanding of Huntington's Disease
Huntington's disease (HD) is a fatal neurodegenerative disease caused by an expanded sequence in the huntingtin gene.
Loading Comments...