NOV 19, 2019 08:21 PM PST

Experimental Cholesterol-Lowering Drug

WRITTEN BY: Nouran Amin

A recent study shows that patients who take a maximum dose of statin drugs in addition to a twice-yearly injection of the experimental cholesterol-lowering drug, inclisiran, was effective at reducing low-density lipoprotein (LDL) cholesterol, often called bad cholesterol. Results of the study were generated from the ORION-10, a phase 3 placebo-controlled, double-blind, randomized clinical trial.

Learn more about LDL cholesterol:

 

 

When increased levels of LDL cholesterol builds up in the walls of the arteries, blood cannot pass through efficiently which leads to blockage. This blockage, as a result of hard and narrow capillaries, puts a patient at risk of heart attacks and strokes. "Maintaining low LDL over a sustained period is essential to reduce the risk of heart attacks and stroke," says R. Scott Wright, M.D., a Mayo Clinic cardiologist and principal investigator of ORION-10 trial.

Inclisiran is the only siRNA drug that works to lower cholesterol. Developed by the Medicines Company, the drug works to mimic a gene variant and prevent the production of the protein PCSK9, this in turn lowers LDL.

"The data show that inclisiran dosed twice-yearly achieved durable and potent LDL reductions with an excellent safety profile, and no treatment-related liver or kidney side effects," Dr. Wright says. "Twice-yearly administration by a health care professional coincides with typical patient visits, which can help with medication adherence."

Source: Science Daily

About the Author
  • Nouran enjoys writing on various topics including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
DEC 12, 2019
Genetics & Genomics
DEC 12, 2019
Non-Invasive Gene Therapy Holds Promise for Treating Blindness
Researchers at John Hopkins Medicine have found a way to deliver sight-saving gene therapy to the retina. Having already shown success in treating rates, p...
DEC 12, 2019
Drug Discovery & Development
DEC 12, 2019
Common Drug May Prevent Thousands Deaths from Head Injury
Each year, there are over 60 million new cases of traumatic brain injury (TBI). Mostly caused by road traffic crashes and falls, TBI often causes intracran...
DEC 12, 2019
Drug Discovery & Development
DEC 12, 2019
Diabetes: The next-generation therapy
A publication in Nature Communications describes a therapeutic that can avoid the side-effects of insulin in diabetic treatments particularly hypoglycemia....
DEC 12, 2019
Cancer
DEC 12, 2019
C2 combination targets cancer cells more efficiently
Treating cancer is in part so difficult because to be effective, high doses of aggressive drugs must be administered to patients. These treatments often ha...
DEC 12, 2019
Cannabis Sciences
DEC 12, 2019
Cannabis Can't Simply Replace Opioids for Pain Management
According to the research, cannabis is not effective when it comes to treating individuals struggling with opioid use disorder. While some may have conside...
DEC 12, 2019
Drug Discovery & Development
DEC 12, 2019
Drug To Treat Ulcerative Colitis
Biomedical researchers at the University of California—Riverside, found that the therapeutic drug ‘tofacitinib’ used in treating autoimmu...
Loading Comments...