DEC 11, 2019 8:11 AM PST

Drug Candidates for Alzheimer Disease May Reverse Effects of Aging

WRITTEN BY: Nouran Amin

Researchers using mouse models of Alzheimer disease were able to demonstrate that the investigational drug candidates ‘CMS121’ and ‘J147’ will not only improve symptoms of memory impairment by slowing the deterioration of brain cells but can also reverse aging.

“This study further validated these two compounds not only as Alzheimer’s drug candidates but also as potentially more widely useful for their anti-aging effects,” says Pamela Maher, a senior staff scientist at Salk Research Institute and a co-corresponding author of the new paper. “The bottom line was that these two compounds prevent molecular changes that are associated with aging.”

Learn more about Alzheimer disease:

Findings were published in the journal eLife and indicates how these drug candidates, which are actually variants of plant compounds with medicinal properties, can inhibit the damage to brain cells that are normally seen during aging and restoring the necessary protein seen in younger brains. The drugs are capable of keeping neurons alive when exposed to forms of cellular stress as a result of aging or from implications of Alzheimer.

“The contribution of old age-associated detrimental processes to the disease has been largely neglected in Alzheimer’s disease drug discovery,” says Antonio Currais, a Salk staff scientist and first author of the new paper.

Results suggest that these drugs hold potential in reversing broader aging and links to a new pathway involved in longevity between aging and the Alzheimer brain. The pathway is likely involved with the cellular organelle and power house of the cell known as the mitochondria.

“There was already some data from human studies that the function of mitochondria is negatively impacted in aging and that it’s worse in the context of Alzheimer’s,” says Maher. “This helps solidify that link.”

“We are now using a variety of animal models to investigate how this neuroprotective pathway regulates specific molecular aspects of mitochondrial biology, and their effects on aging and Alzheimer’s,” says Currais.

Source: The Salk Institute for Biological Studies

About the Author
  • Nouran earned her BS and MS in Biology at IUPUI and currently shares her love of science by teaching. She enjoys writing on various topics as well including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
JAN 27, 2020
Drug Discovery & Development
JAN 27, 2020
Vaccine Causes More Polio Cases than Wild Virus
The World Health Organization (WHO) has confirmed that 11 new cases of polio in five African countries including Nigeria, Congo and Angola were caused by a...
JAN 27, 2020
Drug Discovery & Development
JAN 27, 2020
Could the diabetic drug 'metformin' extend a healthy lifespan?
The most commonly prescribed diabetic medication for the Type 2 condition is ‘Metformin’—a drug with a mysterious mechanism of action but...
JAN 27, 2020
Drug Discovery & Development
JAN 27, 2020
MagLev: Telling Drugs Apart
Likely, a suspicious powder will be composed of illicit drugs but nothing is certain until confirmation. To do so, analysis must be quick and efficient and...
JAN 27, 2020
Drug Discovery & Development
JAN 27, 2020
Vaccine To Protect Against The Zika Virus
Scientists at The University of Texas Medical Branch at Galveston present for the first time how a single high dose vaccine can protect a pregnant mouse al...
JAN 27, 2020
Drug Discovery & Development
JAN 27, 2020
Eye Solution Approved for Surgical Application
As announced by the Dutch Ophthalmic Research Center in a press release, a new eye solution was recently approved by the US Food and Drug Administration fo...
JAN 27, 2020
Drug Discovery & Development
JAN 27, 2020
Using Vitamins to Treat Pediatric Sepsis
New research indicates that is very much possible to treat pediatric septic shock in children with a combination of intravenous vitamin C and intravenous v...
Loading Comments...