DEC 11, 2019 8:11 AM PST

Drug Candidates for Alzheimer Disease May Reverse Effects of Aging

WRITTEN BY: Nouran Amin

Researchers using mouse models of Alzheimer disease were able to demonstrate that the investigational drug candidates ‘CMS121’ and ‘J147’ will not only improve symptoms of memory impairment by slowing the deterioration of brain cells but can also reverse aging.

“This study further validated these two compounds not only as Alzheimer’s drug candidates but also as potentially more widely useful for their anti-aging effects,” says Pamela Maher, a senior staff scientist at Salk Research Institute and a co-corresponding author of the new paper. “The bottom line was that these two compounds prevent molecular changes that are associated with aging.”

Learn more about Alzheimer disease:

Findings were published in the journal eLife and indicates how these drug candidates, which are actually variants of plant compounds with medicinal properties, can inhibit the damage to brain cells that are normally seen during aging and restoring the necessary protein seen in younger brains. The drugs are capable of keeping neurons alive when exposed to forms of cellular stress as a result of aging or from implications of Alzheimer.

“The contribution of old age-associated detrimental processes to the disease has been largely neglected in Alzheimer’s disease drug discovery,” says Antonio Currais, a Salk staff scientist and first author of the new paper.

Results suggest that these drugs hold potential in reversing broader aging and links to a new pathway involved in longevity between aging and the Alzheimer brain. The pathway is likely involved with the cellular organelle and power house of the cell known as the mitochondria.

“There was already some data from human studies that the function of mitochondria is negatively impacted in aging and that it’s worse in the context of Alzheimer’s,” says Maher. “This helps solidify that link.”

“We are now using a variety of animal models to investigate how this neuroprotective pathway regulates specific molecular aspects of mitochondrial biology, and their effects on aging and Alzheimer’s,” says Currais.

Source: The Salk Institute for Biological Studies

About the Author
  • Nouran earned her BS and MS in Biology at IUPUI and currently shares her love of science by teaching. She enjoys writing on various topics as well including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
JUN 23, 2020
Drug Discovery & Development
FDA Warns Against Toxic Hand Sanitizers
JUN 23, 2020
FDA Warns Against Toxic Hand Sanitizers
The COVID-19 pandemic has seen demand for hand sanitizers soar in recent months. As such, the Food and Drug Administrati ...
JUL 19, 2020
Cannabis Sciences
Cannabis May Relieve Pain from Sickle Cell Disease
JUL 19, 2020
Cannabis May Relieve Pain from Sickle Cell Disease
Due to the rise in opioid-associated deaths, physicians and researchers are on the constant lookout for new, healthier o ...
JUL 19, 2020
Drug Discovery & Development
Nanodrug for Treating Invasive Breast Cancer
JUL 19, 2020
Nanodrug for Treating Invasive Breast Cancer
Scientists at the University of Arkansas created a nano-drug that may eradicate triple-negative breast cancer cells. Fin ...
JUL 30, 2020
Immunology
Gene Silencing Therapy Stops the Itch of Psoriasis
JUL 30, 2020
Gene Silencing Therapy Stops the Itch of Psoriasis
A team of Harvard researchers has identified a promising new approach for treating psoriasis — a topical lotion co ...
JUL 13, 2020
Drug Discovery & Development
Potential Therapy for The Dengue Virus
JUL 13, 2020
Potential Therapy for The Dengue Virus
Researchers at the University of Texas Medical Branch at Galveston have uncovered a new antiviral mechanism for the new ...
JUL 20, 2020
Technology
Robots as Models for Medicated Chewing Gum
JUL 20, 2020
Robots as Models for Medicated Chewing Gum
A robot with the ability to chew can provide useful insights on medicated chewing gum for pharmaceutical companies. The ...
Loading Comments...