DEC 11, 2019 8:11 AM PST

Drug Candidates for Alzheimer Disease May Reverse Effects of Aging

WRITTEN BY: Nouran Amin

Researchers using mouse models of Alzheimer disease were able to demonstrate that the investigational drug candidates ‘CMS121’ and ‘J147’ will not only improve symptoms of memory impairment by slowing the deterioration of brain cells but can also reverse aging.

“This study further validated these two compounds not only as Alzheimer’s drug candidates but also as potentially more widely useful for their anti-aging effects,” says Pamela Maher, a senior staff scientist at Salk Research Institute and a co-corresponding author of the new paper. “The bottom line was that these two compounds prevent molecular changes that are associated with aging.”

Learn more about Alzheimer disease:

Findings were published in the journal eLife and indicates how these drug candidates, which are actually variants of plant compounds with medicinal properties, can inhibit the damage to brain cells that are normally seen during aging and restoring the necessary protein seen in younger brains. The drugs are capable of keeping neurons alive when exposed to forms of cellular stress as a result of aging or from implications of Alzheimer.

“The contribution of old age-associated detrimental processes to the disease has been largely neglected in Alzheimer’s disease drug discovery,” says Antonio Currais, a Salk staff scientist and first author of the new paper.

Results suggest that these drugs hold potential in reversing broader aging and links to a new pathway involved in longevity between aging and the Alzheimer brain. The pathway is likely involved with the cellular organelle and power house of the cell known as the mitochondria.

“There was already some data from human studies that the function of mitochondria is negatively impacted in aging and that it’s worse in the context of Alzheimer’s,” says Maher. “This helps solidify that link.”

“We are now using a variety of animal models to investigate how this neuroprotective pathway regulates specific molecular aspects of mitochondrial biology, and their effects on aging and Alzheimer’s,” says Currais.

Source: The Salk Institute for Biological Studies

About the Author
  • Nouran earned her BS and MS in Biology at IUPUI and currently shares her love of science by teaching. She enjoys writing on various topics as well including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
SEP 27, 2020
Cell & Molecular Biology
How Spiders May Open a Path to IBS Treatment
SEP 27, 2020
How Spiders May Open a Path to IBS Treatment
Irritable bowel syndrome (IBS) is term that describes a gut disorder that causes abdominal pain, cramping, diarrhea or c ...
OCT 15, 2020
Neuroscience
Neurometabolism: A bold, new frontier
OCT 15, 2020
Neurometabolism: A bold, new frontier
Billions of neurons communicate with each other through trillions of synapses to create a functioning, unique system we ...
OCT 20, 2020
Cannabis Sciences
Should Cannabis Doses Be Standardized?
OCT 20, 2020
Should Cannabis Doses Be Standardized?
Should cannabis and its compounds such as tetrahydrocannabinol (THC), the psychoactive compound in cannabis, come in sta ...
NOV 02, 2020
Drug Discovery & Development
Beetroot Peptide Shows Promise in Treating Inflammatory Diseases
NOV 02, 2020
Beetroot Peptide Shows Promise in Treating Inflammatory Diseases
Researchers from the Medical Univesity of Vienna in Austria have found that a peptide (a small protein molecule) found i ...
NOV 06, 2020
Drug Discovery & Development
Anti-depressant Shows Promise in Treating Childhood Cancer
NOV 06, 2020
Anti-depressant Shows Promise in Treating Childhood Cancer
Researchers from Sweden and the US have found that a commonly prescribed antidepressant may help stop the growth of a ca ...
NOV 16, 2020
Drug Discovery & Development
A Change of Heart
NOV 16, 2020
A Change of Heart
For a long time cardiovascular issues related to the heart muscular wall have been addressed by therapeutics that target ...
Loading Comments...