SEP 08, 2020 9:04 PM PDT

Anticholinergic Drugs Reported to Cause Cognitive Decline

WRITTEN BY: Nouran Amin

A team of researchers have reported that a class of drugs used for an array of conditions—such as allergies, hypertension and urinary incontinence—could be associated with the increased likelihood of developing Alzheimer's disease (AD). These drugs are known as anticholinergic and they work by blocking acetylcholine activity.

"This study, led by Alexandra Weigand, suggests that reducing anticholinergic drug use before cognitive problems appear may be important for preventing future negative effects on memory and thinking skills, especially for people at greater risk for Alzheimer's disease," said senior author Lisa Delano-Wood, PhD, associate professor in the Department of Psychiatry at UC San Diego School of Medicine.

Findings were published in Neurology, the medical journal of the American Academy of Neurology.

Learn more about anticholinergic drugs:

"We believe this interaction between anticholinergic drugs and Alzheimer's risk biomarkers acts in a 'double hit' manner," said Weigand, the study's first author. "In the first hit, Alzheimer's biomarkers indicate that pathology has started to accumulate in and degenerate a small region called the basal forebrain that produces the chemical acetylcholine, which promotes thinking and memory. In the second hit, anticholinergic drugs further deplete the brain's store of acetylcholine. This combined effect most significantly impacts a person's thinking and memory."

Source: Science Daily

About the Author
  • Nouran earned her BS and MS in Biology at IUPUI and currently shares her love of science by teaching. She enjoys writing on various topics as well including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
AUG 24, 2020
Cell & Molecular Biology
A Shield Surrounds the Flexible SARS-CoV-2 Spike Protein
AUG 24, 2020
A Shield Surrounds the Flexible SARS-CoV-2 Spike Protein
Researchers know that the viruses including SARS-CoV-2 have a Spike protein that allows them to bind to receptors on hos ...
AUG 26, 2020
Cancer
NAP-6: A Potential Candidate for the Treatment of Breast Cancer
AUG 26, 2020
NAP-6: A Potential Candidate for the Treatment of Breast Cancer
The body is an amazing and complex system of pathways, all working together in harmony. However, cancer can quickly disr ...
SEP 03, 2020
Drug Discovery & Development
Combination of Cholesterol Lowering Drugs Effective in Reducing Heart Disease
SEP 03, 2020
Combination of Cholesterol Lowering Drugs Effective in Reducing Heart Disease
A recent European study found that individuals taking a combination of lipid-lowering therapeutics may reduce the risk o ...
SEP 27, 2020
Cell & Molecular Biology
How Spiders May Open a Path to IBS Treatment
SEP 27, 2020
How Spiders May Open a Path to IBS Treatment
Irritable bowel syndrome (IBS) is term that describes a gut disorder that causes abdominal pain, cramping, diarrhea or c ...
OCT 02, 2020
Immunology
Stop the Clot: A New Antibody Treatment for Thrombosis
OCT 02, 2020
Stop the Clot: A New Antibody Treatment for Thrombosis
Blood clotting helps stem the bleeding from a wound, suppressing blood loss and stopping pathogenic microorganisms from ...
OCT 03, 2020
Cannabis Sciences
Cannabis Compound Prevents Colon Cancer in Mice
OCT 03, 2020
Cannabis Compound Prevents Colon Cancer in Mice
Second only to skin cancer, colon cancer is the most common cancer diagnosed in both men and women in the US. Now, resea ...
Loading Comments...