NOV 18, 2020 2:31 PM PST

Hepatitis C Drugs May Be Involved Coronavirus Treatment

WRITTEN BY: Nouran Amin

At the present moment, there are no inhibitors that target protease activity of the novel SARS-CoV-2. The main proteases is a critical protein in the life cycle of the coronavirus, ultimately allowing it to reproduce. However, recently researchers have found that hepatitis C drugs may certainly do the trick in inhibiting/blocking the protease from functioning.

"Currently, there are no inhibitors approved by the Food and Drug Administration that target the SARS-CoV-2 main protease," said ORNL lead author Daniel Kneller. "What we found is that hepatitis C drugs bind to and inhibit the coronavirus protease. This is an important first step in determining whether these drugs should be considered as potential repurposing candidates to treat COVID-19."

Learn more about a protease:

Findings of the study were published in the journal Structure. In addition, researchers used the assistance of modern-day X ray technology to look at the atomic arrangements of how protease and drug inhibitors work.

"What we're doing is laying the molecular foundation for these potential drug repurposing inhibitors by revealing their mode of action," said ORNL corresponding author Andrey Kovalevsky. "We show on a molecular level how they bind, where they bind, and what they're doing to the enzyme shape. And, with in vitro kinetics, we also know how well they bind. Each piece of information gets us one step closer to realizing how to stop the virus."

Source: Science Daily

About the Author
BS/MS
Nouran is a scientist, educator, and life-long learner with a passion for making science more communicable. When not busy in the lab isolating blood macrophages, she enjoys writing on various STEM topics.
You May Also Like
APR 21, 2022
Drug Discovery & Development
No Link Between Antidepressants and Improved Quality of Life
APR 21, 2022
No Link Between Antidepressants and Improved Quality of Life
Those who use antidepressant medications have a similar health-related quality of life to people who are depressed and w ...
MAY 02, 2022
Drug Discovery & Development
Synthetic Coating Improves Survival of Oral Medications During Digestion
MAY 02, 2022
Synthetic Coating Improves Survival of Oral Medications During Digestion
We’re probably all familiar with the (sometimes unpleasant) experience of swallowing pills. Whether ibuprofen for ...
MAY 19, 2022
Drug Discovery & Development
Experimental Drug Shows Promise Against ALS
MAY 19, 2022
Experimental Drug Shows Promise Against ALS
A new experimental drug known as NU-9 may be more effective in treating ALS than existing FDA-approved drugs. The corres ...
MAY 25, 2022
Neuroscience
Exploring Drug Targets in Neurodegenerative Diseases
MAY 25, 2022
Exploring Drug Targets in Neurodegenerative Diseases
Introduction Life expectancy has increased globally over the last several decades. However, longer life expectancy comes ...
JUN 14, 2022
Coronavirus
Advances in Latest Coronavirus Research in the 2022 Ongoing Labroots Virtual Event Series
JUN 14, 2022
Advances in Latest Coronavirus Research in the 2022 Ongoing Labroots Virtual Event Series
Labroots hosted its 3rd annual Coronavirus Conference Virtual Event Series on May 4, 2022. The speaker roster for this f ...
JUN 22, 2022
Cell & Molecular Biology
A New, Innovative Process for Clarifying and Sterile Filtering Cells for Protein Purification Workflows
JUN 22, 2022
A New, Innovative Process for Clarifying and Sterile Filtering Cells for Protein Purification Workflows
Introduction Centrifugation and filtration have been widely accepted as techniques required for clarifying complex cell ...
Loading Comments...