DEC 24, 2020 8:06 PM PST

Diabetic Drug Combo Improves Symptoms

WRITTEN BY: Nouran Amin

Scientists have shown that adding a drug combination widely used in diabetic therapy will control blood glucose and weight loss in mice,

"We have previously shown that prolonged association of the GLP-1 agonists with the glucagon-like peptide 1 receptor supports insulin secretion in pancreatic beta cells," explains project team leader Dr. Prasenjit Mitra of the Dr. Reddy's Institute of Life Sciences. "This led us to see whether we could enhance the effects of GLP-1 agonism on regulating glucose levels with a complementary therapy."

Findings were reported in the journal eLife and describes a new class of drugs called glucagon-like peptide 1 agonists (GLP-1 analogs).

Learn more about diabetes:

"GLP-1 drugs have emerged in the last decade as unique medicines that provide substantial improvements in glycemic control and body weight; however, they seldom achieve full metabolic recovery or help treat associated comorbidities such as body weight," Dr. Mitra explains. "Our results suggest that the class 1 HDAC inhibitor MS-275 can significantly enhance the action of GLP-1 drugs, more effectively normalising blood glucose and reducing weight gain. This lays the foundation for clinical studies of combinations of GLP-1/HDAC inhibitors for the long-term management of diabetes and obesity in humans."

Source: Science Daily

About the Author
  • Nouran is a scientist, educator, and life-long learner with a passion for making science more communicable. When not busy in the lab isolating blood macrophages, she enjoys writing on various STEM topics.
You May Also Like
DEC 28, 2020
Cell & Molecular Biology
How an Herbal Compound May Fight Pancreatic Cancer
DEC 28, 2020
How an Herbal Compound May Fight Pancreatic Cancer
For centuries, Chinese practitioners have used herbs to treat all kinds of ailments. New research has shown that one of ...
FEB 06, 2021
Cannabis Sciences
Cannabis Reduces Disruptive Behavior in 50% of Young People with Autism
FEB 06, 2021
Cannabis Reduces Disruptive Behavior in 50% of Young People with Autism
Current pharmacotherapies for disruptive behaviors among those with autism are relatively ineffective. Now though, resea ...
FEB 18, 2021
Cell & Molecular Biology
Inhibition of a Specific Enzyme Could be a Way to Treat Glioblastoma
FEB 18, 2021
Inhibition of a Specific Enzyme Could be a Way to Treat Glioblastoma
Researchers may have identified a new treatment target for a deadly form of brain cancer. Inhibiting an enzyme called PR ...
MAR 09, 2021
Cannabis Sciences
Cannabis Alleviates Neuropathic Pain from Chemotherapy
MAR 09, 2021
Cannabis Alleviates Neuropathic Pain from Chemotherapy
Neuropathic pain from oxaliplatin-based chemotherapy regimens occurs in up to 90% of patients, and continued exposure to ...
APR 05, 2021
Neuroscience
Could a Keto Diet Treat Alzheimer's Disease?
APR 05, 2021
Could a Keto Diet Treat Alzheimer's Disease?
  Researchers from Brigham Young University have found evidence that eating a ketogenic diet- which is a diet that ...
APR 10, 2021
Drug Discovery & Development
How New ADHD Drug for Children Differs from Adderall
APR 10, 2021
How New ADHD Drug for Children Differs from Adderall
Over 1 in 10 children in the US aged between 5 and 17 have been diagnosed with attention deficit hyperactivity ...
Loading Comments...