FEB 10, 2021 7:50 PM PST

Snail Venom Treats Malaria

WRITTEN BY: Nouran Amin

In a first-of-its-kind study, scientists from Florida Atlantic University's Schmidt College of Medicine in collaboration with FAU's Charles E. Schmidt College of Science and the Chemical Sciences Division, have discovered that the venom from Conus nux can treat malaria.

"Molecular stability, small size, solubility, intravenous delivery, and no immunogenic response make conotoxins excellent blockade-therapy candidates," said Andrew V. Oleinikov, Ph.D., corresponding author and a professor of biomedical science, FAU's Schmidt College of Medicine. "Conotoxins have been vigorously studied for decades as molecular probes and drug leads targeting the central nervous systems. They also should be explored for novel applications aimed to thwart amiss cellular responses or foil host parasite interactions through their binding with endogenous and exogenous proteins. Further investigation is likely to yield breakthroughs in fields continuously toiling for more efficient therapeutic approaches such as cancer, autoimmune diseases, novel emerging viral diseases as well as malaria where venom-based peptidic natural products can be put into practice."

Findings were published in the Journal of Proteomics.

"Among the more than 850 species of cone snails there are hundreds of thousands of diverse venom exopeptides that have been selected throughout several million years of evolution to capture their prey and deter predators," said Frank Marí, Ph.D., corresponding author and senior advisor for biochemical sciences at the National Institute of Standards and Technology. "They do so by targeting several surface proteins present in target excitable cells. This immense biomolecular library of conopeptides can be explored for potential use as therapeutic leads against persistent and emerging diseases affecting non-excitable systems."

Learn more about malaria:

 

 

Source: Science Daily

 

About the Author
BS/MS
Nouran is a scientist, educator, and life-long learner with a passion for making science more communicable. When not busy in the lab isolating blood macrophages, she enjoys writing on various STEM topics.
You May Also Like
APR 14, 2022
Drug Discovery & Development
COVID-19 Drug Combo More Effective than Single Drugs
APR 14, 2022
COVID-19 Drug Combo More Effective than Single Drugs
COVID-19 is more effectively treated by a combination of drugs than singular drugs alone. The corresponding study was pu ...
APR 20, 2022
Drug Discovery & Development
Vitamin E Stimulates Dendritic Cells, Boosts Immunotherapy Effectiveness
APR 20, 2022
Vitamin E Stimulates Dendritic Cells, Boosts Immunotherapy Effectiveness
Dendritic cells play an important role in the immune system. Specifically, they help gather up antigen-presenting cells ...
APR 19, 2022
Drug Discovery & Development
Repurposing an Alcoholism Drug to Treat Anxiety
APR 19, 2022
Repurposing an Alcoholism Drug to Treat Anxiety
Anxiety is the most common mental illness in the U.S. According to the National Institutes of Health, nearly a third of ...
MAY 20, 2022
Drug Discovery & Development
Drug Shows Promise in treating Spinal Cord Injury
MAY 20, 2022
Drug Shows Promise in treating Spinal Cord Injury
A drug developed by AstraZeneca preserves 80% of nerve function following spinal cord compression injury. The correspond ...
JUN 09, 2022
Cancer
A Case Study May Identify a Novel Gene Therapy for Pancreatic Cancer
JUN 09, 2022
A Case Study May Identify a Novel Gene Therapy for Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive pancreatic cancer with limited treatment options.  PDA ...
JUN 15, 2022
Drug Discovery & Development
High Intensity Ultrasound Therapy Treats Localized Prostate Cancer
JUN 15, 2022
High Intensity Ultrasound Therapy Treats Localized Prostate Cancer
High-intensity-focused ultrasound (HIFU) can treat some men with prostate cancer instead of surgery or radiation therapy ...
Loading Comments...