JUN 06, 2022 9:30 AM PDT

New Antibiotic Shows Promise Against Treatment-Resistant Tuberculosis

WRITTEN BY: Annie Lennon

A new class of antibiotics has shown promise in preclinical trials against drug-resistant tuberculosis. The corresponding study was published in PLOS Biology

Each year, around 1.5 million people die from Mycobacterium tuberculosis infection. Although antibiotics exist to treat the bacteria, multi-drug resistant, extensively drug-resistant, and totally drug-resistant strains have developed, and pose a significant health risk.

For the current study, researchers screened a variety of plant extracts to find a new antibiotic capable of treating drug-resistant tuberculosis. They ultimately found deoxypergularinine (DPG), a compound purified from the root of Cynanchum atratum- a flowering plant used in traditional Chinese medicine- that exhibited promising antibacterial activity. 

The researchers created multiple analogs of DPG and tested them for their ability to inhibit M. tuberculosis without harming infected cells. In doing so, they identified a class of derivatives with antitubercular effects and low toxicity. 

They then tested these derivatives on mouse models. Four weeks of treatment with one derivative, known as PP1S, significantly reduced TB infection compared to a control group. The derivative also produced no clinical side effects in healthy rats after two weeks of high-dose treatment. 

Alongside PP1S, the researchers tested a second derivative, PP2S, in mice and found that, likewise, it produced no clinical side effects in healthy rats after two weeks. It also produced no adverse effects after four weeks of intermediate-dose therapy. 

They further noted that after a week of treatment with PP2S, mice underwent no significant changes in their gut microbiome, while other TB drugs produced multiple changes. This effect, says the researchers, is likely as PPS targets a gene called PE_PGRS57, which is found in few species of bacteria. 

"While further testing will be required, the low effective dose and high level of safety in these early tests indicate that these new drugs are likely to be important alternatives to the current regimen for treatment of tuberculosis," said Ho-Yeon Song of Soonchunhyang University in the Republic of Korea, one of the study’s authors, "A new class of PP derivatives is a M. tuberculosis-targeted antimicrobial with microbiome-safe properties."

 

Sources: Science DailyPLOS Biology

About the Author
University College London
Annie Lennon is a writer whose work also appears in Medical News Today, Psych Central, Psychology Today, and other outlets. When she's not writing, she is COO of Xeurix, an HR startup that assesses jobfit from gamified workplace simulations.
You May Also Like
APR 20, 2022
Cancer
"Saturating" the Liver with Chemotherapy to Treat Cancer
APR 20, 2022
"Saturating" the Liver with Chemotherapy to Treat Cancer
Uveal melanoma is a rare type of cancer that grows in the melanin, the dark-colored pigment of the eye. About  ...
APR 22, 2022
Health & Medicine
Differences in the Impact of Acute and Chronic Cannabis Use on Stress Response Regulation
APR 22, 2022
Differences in the Impact of Acute and Chronic Cannabis Use on Stress Response Regulation
A new study published in Frontiers examined the influence of acute and chronic cannabis use on stress regulation. Althou ...
JUN 06, 2022
Immunology
Using Antibodies to Create Potent Cancer Treatments
JUN 06, 2022
Using Antibodies to Create Potent Cancer Treatments
Cancer can arise from a variety of aberrations that cause cells to divide uncontrollably, and form a tumor. The causes o ...
JUN 06, 2022
Drug Discovery & Development
Weight loss Surgery Reduces Cancer Risk and Cancer Deaths
JUN 06, 2022
Weight loss Surgery Reduces Cancer Risk and Cancer Deaths
Weight loss achieved via bariatric surgery among adults with obesity is linked to a lower risk of developing cancer and ...
JUN 09, 2022
Plants & Animals
Traditional Indian Medicine Helps Treat and Manage Type 2 Diabetes
JUN 09, 2022
Traditional Indian Medicine Helps Treat and Manage Type 2 Diabetes
Medicine has been practiced for millennia. Despite the dominance of Western medicine, many traditional approaches to tre ...
JUN 19, 2022
Drug Discovery & Development
Oral Immunotherapy for Peanut Allergy Most Effective Before 12 Months Old
JUN 19, 2022
Oral Immunotherapy for Peanut Allergy Most Effective Before 12 Months Old
Oral immunotherapy for peanut allergies is safer and more effective in children under 12 months old than in toddlers and ...
Loading Comments...