NOV 22, 2017 1:59 PM PST

Bi-Specific Antibodies- New Improvements to Cancer Immunotherapy

WRITTEN BY: Courtney Schaal

In the last several years, immunotherapy has been hailed as the therapeutic breakthrough for cancer that we’ve all been waiting for.  The ability to utilize and manipulate our own immune systems to eradicate cancer is not only highly promising, but has already proven effective in a subset of patients in the clinic – and this is not just in one cancer type – but many.  A lot of attention has been given to immune checkpoint blockade in highly mutagenic cancers such as melanoma and those of the lung, as well as to chimeric antigen receptor T-cell therapy (CAR-T therapy), but a third category is now gaining more attention as well.  This category is that of bispecific antibodies, or BsAbs.   Interestingly, bispecific antibodies were originally hypothesized to be a method to combat cancer as early as the 1980s.  These work through their affinity to two different targets which act to promote tumor progression.  By binding these targets, they in essence block their ability to interact with their normal partners and are then unable exert their oncogenic effects.  They also have the ability to link therapeutic agents to cancer cells to deliver the desired blow of the therapies.  This video, published by Roche in May of 2016, details the use of T-cell bispecific antibodies for use in cancer.

Sources: Roche, Youtube, Nature Reviews

 

 

 

 

About the Author
You May Also Like
JAN 15, 2020
Drug Discovery & Development
JAN 15, 2020
FDA Approves Drugs Faster than Ever- But is That Good?
The Food and Drug Administration (FDA) is approving new drugs for patients on less and less evidence thanks to special programs that streamline their appro...
JAN 20, 2020
Cell & Molecular Biology
JAN 20, 2020
Using Modified Red Blood Cells As a Drug Delivery System
For a drug to be effective, it has to get to the right place to exert its impact....
JAN 15, 2020
Drug Discovery & Development
JAN 15, 2020
Treating Malaria: Molecular Understanding of Drug Interactions
Crystallization is a process central to drug development that despite centuries of facilitating a particular method, chemists are still learning how to gra...
FEB 21, 2020
Drug Discovery & Development
FEB 21, 2020
Healing Bone Fractures
Studies on rats revealed that two existing drugs can boost repair machinery by triggering the release of bone marrow stem cells. Findings were published in...
FEB 28, 2020
Drug Discovery & Development
FEB 28, 2020
How Dietary Supplement Citicoline Improves Memory
For some time now, Citicoline has been known for its ability to improve memory and reduce cognitive decline. A primary ingredient in many pre-made nootropi...
MAR 14, 2020
Chemistry & Physics
MAR 14, 2020
Scientists Developed "Molecular Drills" to Treat Skin Diseases
Molecular machines are small chemical structures that are capable of achieving mechanical tasks that's similar to their macroscopic counterparts, excep...
Loading Comments...