AUG 10, 2019 10:20 AM PDT

Can LSD Treat Addiction?

WRITTEN BY: Annie Lennon

Modern medicine commonly refers to addiction as a brain disease caused by drugs and other negative stimuli. However, evidence is surmounting that addiction may in fact have more fundamental causes. This is bringing about rapid change in the way it may be treated- namingly, with substances previously considered dangerous and taboo such as LSD. 

Although certain drugs and substances may stimulate an addiction response, recent research indicates that it may have another cause: an inability to connect oneself to a sense of deeper meaning, value and purpose. Nowadays, rather than looking at surface factors which may simply stimulate addiction, more and more attention is being given to the fact that addiction itself may occur as a form of escapism from the pain associated with the experience of living. Thus, rather than being a pharmacological condition, addiction may indeed be an existential one (Taub: 2018). 

This is where psychedelics, such as LSD, become interesting in treating addiction. Known to ignite feelings of deeper understanding of life and the world when properly used, psychedelics may be key to addressing existential questions. Their ability to provide different reference points of how reality may be, and to help people confront their fears and limiting beliefs, has been known to make people not only more at peace with their trauma, but more accepting and calm about life in general. This feeling of peace and acceptance is thus an important step towards curing addiction, as it confronts and dissolves any pain associated with living, and perhaps the addiction too (Bleyer: 2017). 

Since LSD was first synthesized, many experiments and studies have demonstrated its efficacy in treating addiction in psychotherapeutic settings. A meta-study looking at six clinical trials between 1966 and 1970, for example, found that of those who had taken LSD as part of their treatment for alcoholism, 59% decreased their alcohol consumption, compared to 38% who did not take LSD (Krebs: 2012). The study further found that participants who took LSD during their therapy were 15% more likely to remain sober six months after leaving treatment than those who did not take LSD (Chant: 2012).

But how did this happen? Short term effects of taking the psychedelic are known to decrease impulsivity and improve mood. However, this downregulation only lasts for a week, and so is unlikely to account for long-term changes. Thus, it has been suggested that psychedelics such as LSD cause neuronal changes that essentially cause a remodeling of the brain that unlearns addiction patterns (Bleyer: 2017). 

This theory may be supported by brain imaging displaying how LSD decreases communication between the brain regions that create the Default Mode Network (DMN), a collection of brain areas that control and repress consciousness. When under LSD, brain imaging has demonstrated how the DMN disintegrates, allowing for an increase in communication between normally segregated brain networks, something that has been associated with more fluid modes of cognition (Carhart-Harrs: 2016). To properly understand the real mechanisms behind its efficacy however, further research is being conducted, as well as modern trials combining LSD with psychotherapeutic practices (MAPS: 2019). 

To conclude, as attitudes towards the cause of addiction are changing- from being caused by substances to being caused by existential crises, attitudes towards treatments are changing too. LSD has a strong historical record of aiding with the condition and, coupled with growing knowledge on neuroscience and the development of psychotherapy alongside new trials, is showing promising signs of becoming an effective treatment for addiction. 


 

Sources 

 

Taub, Benjamin: The Third Wave 

Bleyer, Jennifer: Psychology Today 

Krebs, TS. et al. : Pub Med

Chant, Ian: Scientific American

MAPS 

Carhart-Harris RL. et al. : Beckley Foundation 

About the Author
  • Writer with a keen interest in genetics, psychology, health and everything in between. Currently focused on the interplay of genetics and society to understand how to create meaningful interactions and environments.
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