JUN 09, 2014 12:00 AM PDT

Child

WRITTEN BY: Peter Micheli
Much attention is given to the quality of schools when it comes to producing well-adjusted children that become responsible adults, but new research indicates that it might be much more important and rewarding to focus efforts on the very early preschool years, especially from birth to three years. In a paper entitled "Biological Embedding of Early Childhood Adversity: Toxic Stress and the Vicious Cycle of Poverty in South Africa" by University of Cape Town-affiliated neurobiologist, Barak Morgan, he explains how negative signals from the environment add permanent small molecules called "epigenetic marks" onto DNA during early brain development, even before birth. It is during this time that it is critical for a child to acquire the skills needed to manage their emotions, control aggression and thrive as adults. After this period it becomes very difficult to change these pathways.

The nature vs. nurture debate is an old one. Most people know that we are at the mercy of genes inherited from our parents (nature), but it is not as well known that French scientists Francis Jacob and Jacques Monod won the Nobel Prize in 1969 for discovering that DNA is regulated by the environment (nurture). Morgan writes, "It has become clear that Nature and Nurture, genes and environment, are not only of equal importance, but form an inseparable whole."

The negative signals influencing brain development are more common in poor homes where parents are struggling to just survive and where violence, neglect, poor nutrition and a lack of nurturing may be found. Several years ago a Canadian researcher, Michael Meany found that the amount of licking and grooming received by baby rats in the first days of their lives influenced their response to stress. Those that received the least licking and grooming had more epigenetic marks on the brain's major stress gene. Those that received more attention were better able to cope with stress. It did not matter if the licking and grooming was provided by the biological mother or another rat.

Especially worrisome is that the negative imprinting onto DNA is passed on from one generation to the next, resulting in a continuous cycle of dysfunctional family life and poverty. Jack Shonkoff, director of Harvard's Center on the Developing Child, says, "The quality of the foundation we build in the first couple of years doesn't completely determine everything that is going to come later, but it nevertheless sets you up for a lifetime of good prospects for healthy development, or it puts you in a deep hole that says the risks are much greater that you will have problems across the board."

The type of stress that causes these problems is known as "toxic stress". It is stress that cannot be coped with or can only be coped with at great cost in comparison to "manageable stress", stress that can be coped with. Toxic stress can lead to autoimmune disorders, substance abuse, heart problems, depression, anxiety, poor social skills, teenage pregnancy, delinquency, and suicidal behavior.

The discovery that the effects of toxic stress cause biological changes and can be passed on to subsequent generations makes it obvious that breaking this cycle can have enormous social and economic benefits. But, of course, the usual obstacles of finances and politics are likely to hinder the steps necessary to do that, whether the approach is to fight poverty or to support primary caregivers. But, if more research is conducted that supports the nature and nurture viewpoint and the case for costly interventions can be supported by science, advocacy for them may grow.
About the Author
You May Also Like
DEC 13, 2019
Microbiology
DEC 13, 2019
Using CRISPR to Alter or Kill Bacteria
In recent years, the gene editing tool CRISPR/Cas9 has been applied to a wide variety of different organisms, and now, bacteria....
DEC 13, 2019
Genetics & Genomics
DEC 13, 2019
A 'Molecular Clock' for Determining a Child's Age
This tool can aid in the diagnosis of developmental disorders, including autism spectrum disorder....
DEC 13, 2019
Technology
DEC 13, 2019
Machine-Learning and Epigenetics Drug Discovery
Machine learning is known for detecting patterns seen in complex data—such uniqueness has proven it roles in health and medicine. Now, researchers at...
DEC 13, 2019
Neuroscience
DEC 13, 2019
Alcohol Consumption Linked to Epigenetic Changes in Brain Memory System
For a recovering alcoholic, walking past a familiar bar or attending social events are often challenging situations. In the past, stimuli such as the smell, sight, and sounds of a bar become...
DEC 13, 2019
Genetics & Genomics
DEC 13, 2019
Even Different Species of Butterflies Can Easily Share Genes
After assessing the genomes of twenty species of butterflies, scientists were surprised to find that genes flow easily between them....
DEC 13, 2019
Genetics & Genomics
DEC 13, 2019
Promising New Treatment for Mitochondrial Disease Found in Fruit Flies
Researchers at the University of Cambridge have discovered a protein in fruit flies that can reverse the effects of harmful mutations in mitochondrial gene...
Loading Comments...