NOV 08, 2019 8:30 AM PST

New Way to Determine What Our Genes Do

WRITTEN BY: Annie Lennon

Geneticists at the University of Virginia (UVA) School of Medicine have developed a new way to determine what our genes do. This will not only allow scientists to better understand the genetic causes of certain diseases, but also more effectively map out how new drugs may work on different targets. 

Until now, understanding the function of a specific gene has been very challenging. Usually blocking the function of genes and observing the results, as one gene may have multiple functionalities, it is often difficult to pinpoint causes and correlations precisely. 

According to Michael J. Guertin from UVA’s Department of Biochemistry and Molecular Genetics, “The problem with that approach is that if you make a mutation in a gene, or you delete a gene, then that can perturb the entire system for hours, days or, sometimes, an entire lifetime (Anderton: 2019).”

Moreover, given that some genes are essential for life to function, blocking them to observe effects may result in death of the organism, and thus become a pursuit in vein. 

Due to these complications, Guertin and research scientist Kizhakke Mattada Sathyan sought to develop another way to determine what our genes do. Unlike earlier methods, their new technique makes use of a plant protein to rapidly degrade proteins encoded by genes with more precision and control than previous methods, and without many of the negative downstream effects typically observed (News Staff: 2019). 

Possible at a negligible cost, Guertin said, “It's pretty simple for a competent molecular biology lab to pick up the tools that we provided and adopt this within their research program...And we think it will offer big benefits for them (Anderton: 2019)."

In particular, this new technique is likely to benefit drug development, as it will make it much easier to determine the efficacy of a drug by seeing whether it has the same effect as blocking a gene in lab conditions. 

Moreover, Sathyan added that it may also have a useful application for gardners, “Another good thing about this is that auxins (the plant hormone) are some of the weed killers used in the garden...It has some toxicity, so you could use this new information in the plant world to develop better, safer weed killers (ibid.)."


 

Sources 

 

Anderton, Kate: News Medical 

News Staff: CBS

 

About the Author
  • Science writer with keen interests in technology and behavioral biology. Her current focus is on the interplay between these fields to create meaningful interactions, applications and environments.
You May Also Like
AUG 27, 2020
Genetics & Genomics
Understanding How Animals Make Seasonal Adaptations
AUG 27, 2020
Understanding How Animals Make Seasonal Adaptations
Some animals don't need a new wardrobe to change with the seasons, and scientists have now learned more about how they d ...
SEP 25, 2020
Genetics & Genomics
How Genetics Can Inform Our Understanding of ADHD
SEP 25, 2020
How Genetics Can Inform Our Understanding of ADHD
Scientists have discovered that African-Americans and people of European ancestry may have different genetic causes of a ...
OCT 04, 2020
Cardiology
The Genetics of Body Fat May Shape Health Risks
OCT 04, 2020
The Genetics of Body Fat May Shape Health Risks
The work may help explain why men and women are at risk for different diseases and often respond to different treatments ...
OCT 22, 2020
Cell & Molecular Biology
How a Gene Variant Raises the Risk of Multiple Sclerosis
OCT 22, 2020
How a Gene Variant Raises the Risk of Multiple Sclerosis
Now that sequencing the whole human genome is easier, faster, and cheaper than it used to be, scientists have been able ...
OCT 24, 2020
Genetics & Genomics
Cord Blood Samples Reveal More About the Genetics of Autism
OCT 24, 2020
Cord Blood Samples Reveal More About the Genetics of Autism
The activity of genes in our genome is controlled by many factors, one of which are chemical tags or structural changes ...
NOV 12, 2020
Genetics & Genomics
Liposomes Potentially Safer Alternative to Viruses for CRISPR Delivery
NOV 12, 2020
Liposomes Potentially Safer Alternative to Viruses for CRISPR Delivery
To repair disease-causing errors in the genome, gene editing reagents like those used in CRISPR-Cas9 first have to reach ...
Loading Comments...