MAR 18, 2021 11:15 PM PDT

Cannabis Not as Promising as Hoped for PTSD

WRITTEN BY: Angela Dowden

Medical marijuana is used fairly routinely as a treatment for veterans suffering with PTSD (post traumatic stress syndrome). But this prescribing practice has run ahead of the evidence supporting it. Now that evidence is coming in, it looks somewhat thinner than had been hoped.

New information on the subject comes from a long awaited trial whose results landed this week in PLOS ONE.

The study, led by Marcel Bonn-Miller of the University of Pennsylvania and Sue Sisley of the Scottsdale Research Institute, was funded by a $2.2 million grant from the Colorado Department of Public Health and Environment (CDPHE) to the Multidisciplinary Association of Psychedelic Studies (MAPS). Researchers fought for seven years to obtain approval to conduct the study, and it took three more years to carry it out.

The researchers found little evidence for effectiveness of cannabis in PTSD, though it was a safe and well-tolerated treatment.

76 military veterans with PTSD (mostly men between the ages of 24 and 77) were involved in the study in which participants were randomized to receive cannabis equivalent to 2-3 joints daily, or a placebo, for 21 days prior to a 2-week washout period followed by re-randomization to one of three cannabis treatment groups. In the second phase, some participants self-administered cannabis with 12% THC over three weeks, others received an 11% CBD product with minimal THC and a third group received a balanced THC-CBD product, containing roughly 8% THC and 8% CBD. A fourth and final group received a placebo with almost zero active cannabinoids.

The results found that in this randomized placebo-controlled trial of smoked cannabis for PTSD, no active treatment statistically outperformed placebo.

All treatment groups, including placebo, showed good tolerability and significant improvements in PTSD symptoms during three weeks of treatment. In fact, nearly half of the veterans who received a placebo believed they had been given active cannabis.

The study’s authors cited several confounding factors that may have contributed to the results, including issues surrounding the quality and potency of the National Institute on Drug Abuse-supplied cannabis and the fact that the study sample included participants with a history of cannabis use.

“The recruitment of active cannabis users might have increased the potential for biased responding,” the researchers wrote. “Despite many participants already having experience with the drug, nearly half of those receiving placebo believed that they received active cannabis. Prior expectations about cannabis’ effects might explain why even those in the placebo condition reported larger than average reductions in PTSD symptoms after only 3 weeks of treatment.”

Sources: Leafly, PLOS ONE

About the Author
  • I'm a journalist and author with many year's experience of writing for both a consumer and professional audience, mostly on nutrition, health and medical prescribing. My background is food science and I'm a registered nutritionist.
You May Also Like
MAR 29, 2021
Microbiology
High-Fiber Diets Can Alter the Microbiome Quickly & Significantly
MAR 29, 2021
High-Fiber Diets Can Alter the Microbiome Quickly & Significantly
We know that the microbes in the gut have a significant effect on human biology, and researchers are starting to learn m ...
MAR 29, 2021
Cardiology
Learning More About How Stress Breaks the Heart
MAR 29, 2021
Learning More About How Stress Breaks the Heart
Scientists are learning more about what causes a real phenomenon known as broken heart syndrome, or stress-related cardi ...
APR 02, 2021
Genetics & Genomics
A New Neurodevelopmental Disorder is ID'ed
APR 02, 2021
A New Neurodevelopmental Disorder is ID'ed
Researchers have identified a genetic disease that causes neurodevelopmental disorders in some affected kids. The diseas ...
APR 09, 2021
Microbiology
A Neurological Disorder Sometimes Seen After Vaccinations
APR 09, 2021
A Neurological Disorder Sometimes Seen After Vaccinations
Functional neurological disorder (FND) is a real neuropsychiatric disorder that some people have after medical procedure ...
APR 11, 2021
Genetics & Genomics
Trial Shows Personalized Cancer Vaccines are Safe
APR 11, 2021
Trial Shows Personalized Cancer Vaccines are Safe
Vaccines are mostly known as tools to prevent illness. But cancer vaccines are a bit different, and aim to treat existin ...
APR 01, 2021
Chemistry & Physics
Analyzing nitrogen dioxide with deep learning
APR 01, 2021
Analyzing nitrogen dioxide with deep learning
Researchers from Penn State are looking to deep learning to act as a method for improving air quality predictions. The r ...
Loading Comments...