AUG 19, 2016 4:06 PM PDT

"Healthy Obesity" May be a Myth

WRITTEN BY: Julianne Chiaet
Back in December, I wrote an article titled "Being 'Lean and Unfit' is Better Than Being 'Fat and Fit’" that outlined research suggesting normal weight men, regardless of their fitness level, were at a lower risk of death than obese individuals in the highest quarter of aerobic fitness. The article ended up being the most popular one I’ve written for this publication - and this popularity was partly due to the fact that the research was both highly disconcerting and directly affected many individuals (specifically, individuals on Reddit). 
 
Credit: Ryden et al./Cell Reports 2016

In general, those considered metabolically fit have a high sensitivity to the hormone insulin. Until recently, medical experts estimated that up to 30 percent of obese individuals were metabolically healthy; and these individuals were less prone to obesity-related complications. 

Obesity-related complications include cancer, heart disease, and stroke. Symptoms of these diseases don’t always lie in areas where extra fat has accumulated. Yet, obesity increases the risk of those diseases because it is a condition of systemic inflammation, according to research from the Institute for Molecular Medicine.

Now, research published on August 18 in Cell Reports has provided further evidence that being healthy while obese is a myth.

Researchers found that white tissue samples from obese patients showed nearly identical abnormal changes in gene expression in response to insulin regardless of whether the patient was metabolically healthy or unhealthy.
 
"The findings suggest that vigorous health interventions may be necessary for all obese individuals, even those previously considered to be metabolically healthy,” said Mikael Rydén, first author of the paper, from the Karolinska Institutet. "Since obesity is the major driver altering gene expression in fat tissue, we should continue to focus on preventing obesity."

The researchers are currently tracking the participants post-bariatric surgery to see whether the weight loss normalizes gene expression in response to insulin stimulation. 

Source: Cell Press press release via EurekAlert!Cell Reports, Rydén et al.: "The Adipose Transcriptional Response to Insulin Is Determined by Obesity, Not Insulin Sensitivity" 
About the Author
  • Julianne (@JuliChiaet) covers health and medicine for LabRoots. Her work has been published in The Daily Beast, Scientific American, and MailOnline. While primarily a science journalist, she has also covered culture and Japanese organized crime. She is the New York Board Representative for the Asian American Journalists Association (AAJA). • To read more of her writing, or to send her a message, go to Jchiaet.com
You May Also Like
DEC 17, 2020
Drug Discovery & Development
Molecular Mechanism Behind Ketamine for Depression Discovered
DEC 17, 2020
Molecular Mechanism Behind Ketamine for Depression Discovered
Over 30% of people with major depressive disorder are resistant to serotonin reuptake inhibitors (SSRI's), the curre ...
DEC 18, 2020
Microbiology
Wildfire Health Hazards Include Airborne Microbes
DEC 18, 2020
Wildfire Health Hazards Include Airborne Microbes
Research has shown that air pollution & smoke can have serious detrimental health effects. Now scientists have revealed ...
DEC 23, 2020
Cancer
A Combination of Photo and Sonodynamic Therapies Could Assist in Treating Brain Cancer
DEC 23, 2020
A Combination of Photo and Sonodynamic Therapies Could Assist in Treating Brain Cancer
Brain cancer is an incredible challenge for modern medicine. Most drugs don’t make it past the blood-brain barrier ...
DEC 25, 2020
Immunology
A High-Fat Diet Starves Immune Cells, Tumor Growth Goes Unchecked
DEC 25, 2020
A High-Fat Diet Starves Immune Cells, Tumor Growth Goes Unchecked
  Sitting down to enjoy an indulgent Christmas feast? A recent study in mice by Harvard Medicine scientists found t ...
DEC 29, 2020
Clinical & Molecular DX
Injectable Heart Health Tracker Now Picks Up COVID Red Flags
DEC 29, 2020
Injectable Heart Health Tracker Now Picks Up COVID Red Flags
The statistics are a real eye-opener: in the United States, one person dies every 36 seconds from cardiovascular disease ...
JAN 11, 2021
Neuroscience
Religion Promotes Psychology-backed Methods to Manage Distress
JAN 11, 2021
Religion Promotes Psychology-backed Methods to Manage Distress
Researchers from the University of Illinois Urbana-Champaign have found that psychologists recommend similar mechanisms ...
Loading Comments...