MAR 06, 2019 4:33 PM PST

Welcome to the Immune Family

WRITTEN BY: Nicholas Breehl

Researchers have discovered how a tiny molecule is known as miR-132 acts as a "handbrake" on our immune system -- helping us fight infection.

The scientists say the findings could lead to new treatments for life-threatening infections such as leishmaniasis, as well as autoimmune and chronic inflammatory diseases.

Our immune system protects us from invading pathogens but also can over-react, causing irreparable damage to our tissue. When fighting a long-lived infection, the spleen can become bigger as it attacks the invader.

Although this is necessary for an effective immune response, if the spleen becomes too big, as occurs in some infections, this can stop the immune system working properly, leading to severe clinical complications and even death.

A study, funded by the Medical Research Council, led by researchers at the University of York and carried out in collaboration with Queen Mary University London, discovered a novel mechanism that promotes explicitly immune responses to protect from infection.

At the heart of it all is a tiny part of our genome named miR-132. This belongs to a family of genes called microRNAs. The research revealed that miR-132 controls how immune cells respond to infection.

In a pre-clinical model of visceral leishmaniasis (a fatal parasitic disease) lack of miR-132 limits spleen enlargement but also the immune response. This leads to increased susceptibility to infection.

The team discovered that although miR-132 is not a protein itself, it masters activation of immune cells by harnessing the protein-making super engines of the cell called ribosomes.

Through pacing these "enthusiastic engines," miR-132 ensures that immune responses persist as long as is required for optimal parasite clearance.

Dr Dimitris Lagos, Senior Lecturer in Immunology at Hull York Medical School, University of York said: "When you are responding to an infection your immune system protects you and keeps you alive, but it can also be the thing that makes you ill and getting that balance wrong is what usually leads to a chronic infection.

"We looked at which molecules help you and in particular the role of the miR-132. It is a very small part of your DNA, but we discovered that it helps control how other molecules work.

"It acts as a pacer, making sure your immune system doesn't go too fast and get exhausted. It seems like in this case driving with a handbrake on is the way our body protects us from infection."

"This discovery opens novel routes of clinical intervention that aims to promote protective immunity and limit damage in life-threatening infections."

Researchers say the next stage will be to develop drugs that promote the beneficial effects of miR-132 in the immune system.

The findings are published in the journal EMBO Reports.

Sources: Science Daily, EMBO, YouTube

About the Author
You May Also Like
JAN 27, 2020
Cardiology
JAN 27, 2020
Strep Throat Can Lead To Heart Complications
Rheumatic fever (RF) is a complication resulting from untreated strep throat. Caused by group A streptococcal infection, rheumatic fever was once the numbe...
JAN 27, 2020
Immunology
JAN 27, 2020
A Food Additive Could Make Your Cat Hypoallergenic
With 10-30% of the population reporting sensitivity to cat dander, you probably know someone with a cat allergy.  That's why scientists at Nestl&e...
JAN 27, 2020
Immunology
JAN 27, 2020
Your Immune Response Varies from AM to PM
“My biological clock is ticking.” We’ve heard people say this phrase - maybe even said it ourselves - but what do we mean exactly? Often...
JAN 27, 2020
Immunology
JAN 27, 2020
Harnessing the Power of Natural Killer Cells to Fight Cancer
Manipulating the immune system’s population of natural killer cells could bolster therapies targeting cancer. A new study saw positive results invest...
JAN 27, 2020
Immunology
JAN 27, 2020
Protecting Killer Immune Cells from Themselves
Destroying human cells compromised by viruses and cancer is the name of the game for so-called “killer” cells of the immune system. They employ...
JAN 27, 2020
Drug Discovery & Development
JAN 27, 2020
Vaccine To Protect Against The Zika Virus
Scientists at The University of Texas Medical Branch at Galveston present for the first time how a single high dose vaccine can protect a pregnant mouse al...
Loading Comments...