JUN 16, 2021 7:00 AM PDT

Researchers Identify a Novel COVID Therapeutic Target and Mortality Predictor

WRITTEN BY: Tara Fernandez

Researchers at King’s College London have discovered a new antiviral target to combat COVID-19: the galectin-3-binding protein, or LGALS3BP. 

Analysis of around 500 blood samples from COVID-19 patients admitted to the intensive care unit revealed that during infection, LGALS3BP levels in the lungs were significantly elevated. The scientists found that the interaction between the SARS-CoV-2 spike protein and LGALS3BP may be a novel therapeutic target to help alleviate the life-threatening symptoms of COVID-19.

Additionally, the researchers found that the presence of SARS-CoV-2 RNA in the blood of COVID-19 patients could be used as a predictive mortality marker. 56 percent of ICU patients who had succumbed to severe COVID-19 symptoms had detectable viral RNA in the blood, compared to just 13 percent of those who survived the infection.

"We report that presence of detectable viral RNA in plasma or serum of COVID-19 patients is associated with increased risk of severe illness. We also highlight a novel interaction with potential antiviral effect between the SARS-CoV-2 spike protein and a protein called galectin-3-binding protein,” said Manu Shankar Hari, who led the research. 

“Our research findings have two main implications. First, there is an unmet diagnostic technology need for near patient tests to identify the presence of viral RNA in blood in COVID-19 patients. Second, our research potentially highlights an antiviral drug target, which is a priority area highlighted within the UK government's launch of a COVID-19 antivirals Taskforce."

 


Sources: Nature Communications, King's College London.

About the Author
  • Tara Fernandez has a PhD in Cell Biology and has spent over a decade uncovering the molecular basis of diseases ranging from skin cancer to obesity and diabetes. She currently works on developing and marketing disruptive new technologies in the biotechnology industry. Her areas of interest include innovation in molecular diagnostics, cell therapies, and immunology. She actively participates in various science communication and public engagement initiatives to promote STEM in the community.
You May Also Like
APR 21, 2021
Health & Medicine
Topical Probiotics Are a Beneficial Acne Treatment
APR 21, 2021
Topical Probiotics Are a Beneficial Acne Treatment
Research underway is showing topical probiotics to be a beneficial treatment for acne vulgaris. Topical probiotics are a ...
MAY 17, 2021
Immunology
Understanding Inflammation: A Faster, Easier Way to Detect Cytokines in Cells
MAY 17, 2021
Understanding Inflammation: A Faster, Easier Way to Detect Cytokines in Cells
Inflammation, a process that was meant to defend our body from infection, has been found to contribute to a wide range o ...
MAY 18, 2021
Immunology
A Silver Bullet Against COVID Variants?
MAY 18, 2021
A Silver Bullet Against COVID Variants?
Canadian researchers have discovered an antiviral drug that blocks the SARS-CoV-2 virus from infecting lung cells. Promi ...
MAY 19, 2021
Drug Discovery & Development
Combination Immunotherapy Shows Promise in Treating HIV
MAY 19, 2021
Combination Immunotherapy Shows Promise in Treating HIV
  Researchers have found that a new combination immunotherapy, alongside antiretroviral therapy (ART), is effective ...
JUL 29, 2021
Drug Discovery & Development
What is Ivermectin and Can it Treat COVID?
JUL 29, 2021
What is Ivermectin and Can it Treat COVID?
Lab tests in 2020 found that the widely available drug ivermectin had a weak effect on the SARS-CoV-2 virus and that unf ...
AUG 03, 2021
Health & Medicine
Viruses and Autoimmunity: What Pandemics Have Taught Us
AUG 03, 2021
Viruses and Autoimmunity: What Pandemics Have Taught Us
COVID-19 infections have given rise to COVID long haulers, people who had COVID and continue to have symptoms months aft ...
Loading Comments...