JUL 15, 2021 7:00 AM PDT

Your Immune System Can't Deal With All the Plastic You're Eating

WRITTEN BY: Tara Fernandez

Microplastics—tiny fragments of plastic, less than five millimeters in diameter—pollute our environment and, according to scientists, also adversely affect animal health. Research also points to a connection between the ingestion of microplastics present in food and water and its toll on the human immune system.

We are consuming about a teaspoon of microplastics on a weekly basis, estimate scientists. Once ingested, these particles get red-flagged by macrophages, specialized immune cells that “gobble up” and eliminate invading pathogens and foreign bodies.

In an article featured in the journal Cell Biology and Toxicology, immunologist Eliseo Castillo and colleagues at the University of New Mexico studied the impact of polystyrene microplastics on macrophage biology. Once the pieces of plastic were internalized by these cells, they began churning out a suite of pro-inflammatory molecules, triggers for chronic conditions such as inflammatory bowel disease.

According to Castillo, this points to the theory that microplastics are altering and disrupting macrophage metabolism. 

“During intestinal inflammation – states of chronic illness such as ulcerative colitis and Crohn’s disease, both forms of IBD – these macrophages become more inflammatory, and they’re more abundant in the gut,” commented Castillo.

The bad news is that this is not an isolated phenomenon. There are likely knock-on effects on other aspects of the immune system as well, given that it is part of an intricate, interconnected network of cells.

The authors explain that our immune systems have not evolved to deal with these relatively “new” threats present in our environment. The risk is that chronic exposure to these particles could leave us vulnerable to the development of autoimmune conditions.

What’s clear is that there are no quick fixes to shield against the effects of microplastics on human health. Preliminary studies from the research team indicate that biodegradable plastics could be even worse for our health, leaching toxic chemical compounds as they break down.

 

Sources: UNM Health Sciences, Cell Biology and Toxicology.



 

About the Author
  • Tara Fernandez has a PhD in Cell Biology and has spent over a decade uncovering the molecular basis of diseases ranging from skin cancer to obesity and diabetes. She currently works on developing and marketing disruptive new technologies in the biotechnology industry. Her areas of interest include innovation in molecular diagnostics, cell therapies, and immunology. She actively participates in various science communication and public engagement initiatives to promote STEM in the community.
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