MAR 14, 2016 2:52 PM PDT

Defining the Role of Tumor Necrosis Factor During Chronic Viral Infections

WRITTEN BY: Kara Marker
Some viral infections, like HIV, are chronic, while others are acute. HIV infections are labeled chronic because the virus targets and kills helper T cells, and without these lymphocytes the body cannot fight off the HIV infection. Viruses causing acute infections, like the seasonal “stomach bug,” work differently and can be eliminated by the body.

New research from a collaboration between the University of Bonn, University of Cologne, and the Technical University of Munich has led to the discovery of an explanation for why certain viral infections are chronic and others are not. This same discovery has promise for generating new therapeutic targets.
 
Helper T cells secrete inflammatory messengers, a kind of “distress call” to killer T cells to come to their aid and fight off invading pathogens. However, viruses that cause a chronic infection, like HIV, employ virulence factors to silence these messages, ironically rendering the helper T cells helpless and ineffective.
 
In the recent collaborative study, published in the journal Nature Immunology, scientists studied mice models of chronic viral infection to see which helper T cell genes remain active when silenced by viruses. They were able to implicate tumor necrosis factor (TNF) as an agent of chronic viral infection. TNF controls various signaling pathways that inhibit helper T cell activity during chronic inflammation. In mice suffering from HIV-esque chronic viral infections with TNF inactivated, helper T cells produce inflammatory messengers like normal.
 
TNF plays a role in several different functions.

 
“After ten days, the animals had completely eliminated the virus; they were healthy,” explained Dr. Marc Beyer from the University of Bonn.
 
Meanwhile, during acute viral infections, TNF has the opposite effect. It boosts the immune system and stimulates apoptosis in cells corrupted by viral particles.
 
“In an acute infection, large quantities of TNF are formed very rapidly," said Dr. Zeinab Abdullah from the University of Bonn. "In chronic infections, on the other hand, the body secretes small amounts of TNF over a long period of time. This appears to cause the helper T cells to shut down to some extent."
 
The difference seems to stem from some sort of protective mechanism that prevents healthy tissues from being damaged from persistent inflammation, however the team is still in the dark about how exactly TNF works on a molecular level. For the time being, TNF inhibitors could be useful as a therapeutic treatment for patients with chronic viral infections like they are currently used for patients with rheumatoid arthritis and other autoimmune diseases.
 
 
Source: University of Bonn
 
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
JUL 26, 2021
Cell & Molecular Biology
Cells Have a Self-Defense Mechanism Against Bacteria
JUL 26, 2021
Cells Have a Self-Defense Mechanism Against Bacteria
There are natural detergents that cells can use to defend themselves from pathogens. Scientists have now identified a pr ...
AUG 10, 2021
Immunology
A Tapeworm Drug as a COVID Antiviral?
AUG 10, 2021
A Tapeworm Drug as a COVID Antiviral?
A study by researchers at the Scripps Research Institute looking into potential COVID-19 medications has revealed a surp ...
AUG 13, 2021
Cancer
Ultrasound Triggers Immunotherapy to Destroy Tumors
AUG 13, 2021
Ultrasound Triggers Immunotherapy to Destroy Tumors
An immunotherapy engineered to be triggered by ultrasound beams significantly slows the growth of cancerous tumors in mi ...
AUG 26, 2021
Immunology
Sugar-Coating Organs Stops Them From Getting Rejected
AUG 26, 2021
Sugar-Coating Organs Stops Them From Getting Rejected
Once organ failure patients receive the gift of a transplant, they face a life-long threat of immune rejection. Their im ...
OCT 07, 2021
Cancer
Dual Threat: CAR T Cells Modified to Target Two Neuroblastoma Antigens
OCT 07, 2021
Dual Threat: CAR T Cells Modified to Target Two Neuroblastoma Antigens
Neuroblastoma is a cancer of immature nerve cells found in various areas, including the adrenal glands, neck, chest ...
OCT 14, 2021
Immunology
'Bio-Betters' Form the Next Wave of Cancer Therapies
OCT 14, 2021
'Bio-Betters' Form the Next Wave of Cancer Therapies
  Antibodies are blood proteins with highly specialized functions: to recognize and eliminate bacteria, viruses, an ...
Loading Comments...