AUG 01, 2016 2:17 PM PDT

Immunotherapy Target Identified For Ovarian Cancer Treatment

WRITTEN BY: Kara Marker
A new treatment for the selective targeting of ovarian cancer cells has been adopted from chimeric antigen receptor (CAR) T cell technology, thanks to scientists from The Wistar Institute in Philadelphia, Pennsylvania. 

Instead of targeting antibody fragments, the technique used in CAR T cell technology, the new method targets a hormone whose expression is unique to ovarian cells. The receptor-protein is expressed on the surface of two of the most aggressive types of ovarian cancer: clear cell and mucinous ovarian tumors. 
Credit: ovariancancerday.org
“Ideally, we’d like to see this technology used after initial treatment with surgery and chemotherapy,” said postdoctoral fellow and first author of the study Alfredo Perales-Puchalt, MD, PhD. The new treatment is uniquely non-invasive and non-toxic due to its specificity to ovarian cells, leaving the rest of the body’s cells unaffected. 

In their study of mice with ovarian cancer, The Wistar Institute scientists found the receptor-protein, follicle-stimulating hormone receptor (FSHR), expressed on the surface of about 70 percent of cell ovarian carcinomas, 67 percent of mucinous ovarian carcinomas, and 33 percent of of clear cell ovarian carcinomas. By developing T cells designed to target cells expressing FSHR, the researchers uncovered a completely new way to selectively target different types of ovarian cancer with almost zero adverse effects. The Ovarian Cancer National Alliance predicts more than twenty thousand new cases of ovarian cancer will occur in 2016 in the United States, with more than fourteen thousand women dying of the disease.

CAR T cell technology also has scientists excited about the new possibilities of selectively targeting tumor cells, reducing the toxic side effects of many existing cancer treatments. However, CAR T cell technology is currently limited to B cell blood cancers, namely chronic lymphocytic leukemia. Evolving CAR T cell technology to what researchers are now calling “chimeric endocrine receptor-expression T cells (CER-T),” scientists are beginning the process of diversifying the original idea that inspired CAR T cell technology.

Researchers tested CER-T in immunodeficient mice, with the experimental T cells programmed to target ovarian cancer cells expressing FSHR with the full-length sequence of hormone. They had success in getting the mice to reject established tumors of human origin, and when tested in mice with normal, healthy immune systems, the researchers saw no negative side effects.

Scientists responsible for the study believe that this new therapy, in conjunction with surgery and chemotherapy, could help reduce the risk of cancer recurrence, which remains a major concern for patients fighting ovarian cancer.

The study was recently published in the journal Clinical Cancer Research. 
 


Sources: The Wistar Institute, Ovarian Cancer National Alliance  
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
AUG 20, 2021
Drug Discovery & Development
One Vaccine to Rule Them All: Researchers One Step Closer to Universal Vaccine
AUG 20, 2021
One Vaccine to Rule Them All: Researchers One Step Closer to Universal Vaccine
Researchers have identified two antibodies that can protect animals from diseases caused by alphaviruses, which are RNA ...
SEP 12, 2021
Coronavirus
Real-World, Post-Delta COVID-19 Vaccine Data & Potential Treatment
SEP 12, 2021
Real-World, Post-Delta COVID-19 Vaccine Data & Potential Treatment
New research may have identified a potential treatment or preventive medication for SARS-CoV-2 and other viral infection ...
SEP 21, 2021
Immunology
1 in 5 Hospitalized COVID Patients Develop Self-Destructive Antibodies
SEP 21, 2021
1 in 5 Hospitalized COVID Patients Develop Self-Destructive Antibodies
One in five hospitalized COVID-19 patients go on to develop autoantibodies—immune molecules that mistakenly target ...
OCT 05, 2021
Immunology
Inflammation Overload Triggers 'Microclots' in COVID Long-Haulers
OCT 05, 2021
Inflammation Overload Triggers 'Microclots' in COVID Long-Haulers
Months after COVID symptoms have subsided, some individuals continue to grapple with the lingering effects of the infect ...
OCT 19, 2021
Drug Discovery & Development
Researchers develop a potent antiviral drug for dengue fever
OCT 19, 2021
Researchers develop a potent antiviral drug for dengue fever
Dengue fever is a mosquito borne illness that is widespread, especially in tropical countries. The global incidence of d ...
NOV 01, 2021
Cell & Molecular Biology
How SARS-CoV-2 Evades Antiviral Defenses
NOV 01, 2021
How SARS-CoV-2 Evades Antiviral Defenses
Researchers have learned a lot about the SARS-CoV-2 virus since the start of the COVID-19 pandemic. We know that he viru ...
Loading Comments...