SEP 14, 2016 7:31 PM PDT

The "Universal Remote" of All Flu Vaccines

WRITTEN BY: Kara Marker
From the first scientist to ever discover broadly neutralizing antibodies, a new candidate for protection from influenza virus has been found. 
Credit: Louise Scharf/Caltech
Wayne Marasco, MD, PhD, was the first scientist to discover broadly neutralizing antibodies in 2009. These are antibodies that, as their name suggests, are able to target and neutralize a wide variety of viruses, and scientists often study broadly neutralizing antibodies in experiments looking for a way to vaccinate against HIV. 

From the Dana Farber Cancer Institute, Marasco and his team described a protein called 3I14 mAb, a broadly neutralizing antibody found to be capable of adapting to recognize different viruses, in their study recently published in the journal Nature Communications.

Marasco and his team analyzed blood samples from seven blood bank donors, where they eventually identified 3I14 as a new antibody. In the lab, they challenged B cells, immune lymphocytes designed to create antibodies during the adaptive immune response, obtained from the blood samples with different types of influenza to see how they would respond. 

Influenza virus mutates so frequently that the vaccine changes every year, which is why one vaccine won’t protect an individual for life. However, one population of B cells in the study appeared to be responsive to every single influenza strain tested. When the researchers isolated the gene responsible for the high-quality protection, 3I14 mAb was discovered.

They also observed just how 3I14 was uniquely able to bind to multiple types of influenza. 3I14 antibodies bind to a part of the virus that doesn’t change even among mutations, called the “stem.”

Next, they challenged the same B cells with a type of bird flu virus called H5 so they could be certain that the cells had never encountered this particular strain of influenza. 3I14 didn’t bind strongly at first, but a single DNA mutation applied in the lab increased its binding strength by tenfold, an incredible improvement considering the mutation was easily induced and is often found in nature.

After more research, scientists found that 3I14 is capable of recognizing and disabling a diverse group of the 18 different strains of influenza virus that infect people all around the world. Specifically, 3I14 antibodies neutralize two main types of influenza virus: group 1 and group 2. 

The influenza virus mutates both suddenly and slowly over time, a tendency exacerbated by the combination of human virus strains with strains that traditionally infect animals. Every year, scientists predict which strains will be most prevalent and develop vaccines for those strains to protect as many people as possible. With a new vaccine based on the 3I14 broadly neutralizing antibody, scientists could protect people from many more variants of influenza virus.
 


Sources: Dana Farber Cancer Institute, Flu.gov, Caltech 
 
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
FEB 21, 2020
Drug Discovery & Development
FEB 21, 2020
New Antibiotics Found Using AI Technology
Using AI, researchers at MIT have found a powerful new antibiotic capable of killing some of the most dangerous drug-res ...
MAR 07, 2020
Drug Discovery & Development
MAR 07, 2020
Do Surgical Masks Really Prevent the Spread of COVID-19?
As COVID-19 has spread around the world, there has been a global run on surgical masks. This has led some governments, s ...
MAR 19, 2020
Infographics
MAR 19, 2020
All You Need to Know About Coronavirus (CoVID-19)
A new coronavirus, first identified in China in December 2019, has caused an outbreak of respiratory illness that was re ...
APR 01, 2020
Immunology
APR 01, 2020
New Airway-Hugging Immune Cells Discovered in the Lung
  Scientists have discovered a previously unknown subset of immune cells residing in the lung that specifically com ...
APR 02, 2020
Immunology
APR 02, 2020
Transforming T Cells into Powerful Memory Cells That Target Cancer
New cancer treatments are now based on harnessing the power of the human body’s own immune cells to get the job do ...
APR 22, 2020
Immunology
APR 22, 2020
Scientists Engineer Custom Antiviral Receptors to Fight COVID-19
The best offense may be a good defense in the fight against COVID-19. Researchers from the Duke-NUS Medical School are e ...
Loading Comments...