FEB 20, 2019 09:10 AM PST

Lupus Flares are Connected to a Gut Microbe

WRITTEN BY: Carmen Leitch

There is a large microbial community that lives in the human gut, and that community has been connected to a wide variety of disorders. As scientists learn more about the gut microbiome, they’re finding that it can influence the health of its host through bacterial gene expression, changes in the way that the microbes take up nutrients, or how the gut lining is impacted, for example. That lining is closely related to our immune system, and problems in the immune system can cause many diseases, such as arthritis. New work has indicated that systemic lupus erythematosus (SLE), another immune disorder, is associated with a bacterium found in the human gut. The research has been reported in the Annals of Rheumatic Diseases.

SLE or lupus is characterized by flares of joint pain, fatigue, and rash, and can impair several organs including the kidneys. The causes are unclear, although genetics may play a role. It impacts around 1.5 million people in the US and is more common in women. 

This study found that 61 women with SLE carried about five times as much of a gut bacterium called Ruminococcus gnavus compared to seventeen healthy women of similar races and ages. The team also found that flares of the disease tracked with increases in R. gnavus levels in the gut. In the blood, antibodies for the bacterium were similarly increased. In patients with kidney flares, there were particularly high levels of R. gnavus antibodies.

"Our study strongly suggests that in some patients bacterial imbalances may be driving lupus and its associated disease flares," said the senior investigator of the study, immunologist Gregg Silverman, MD. "Our results also point to leakages of bacteria from the gut as a possible immune system trigger of the disease, and suggest that the internal gut environment may, therefore, play a more critical role than genetics in renal flares of this all too often fatal disease.”

 Silverman who is a professor in the departments of Medicine and Pathology at NYU Langone Health, suspects that R. gnavus antibodies trigger the immune system to launch a "continuous and unrelenting" attack on organs. He suggested that a blood test could be used in the future to track antibody levels even in the early stages of the disease. Current methods used for testing are inconclusive and unreliable, especially at early stages, he noted.

More work will be needed on a larger group of patients to confirm these findings, Silverman cautioned. This research could help shift treatment approaches for the disorder, however. It’s possible that future treatment efforts would focus on altering the microbiome to prevent the growth of R. gnavus and stop flares. Fecal transplants pr probiotics may also be useful. Hundreds of bacteria compose the human gut microbiome, and one microbe, Bacteroides uniformis, is thought to impede R. gnavus growth. 

Researchers will be learning more about these and other microbes in the years to come. One day, probiotics might be an important part of disease therapeutics for lupus and other disorders.


Sources: AAAS/Eurekalert! Via NYU Langone Health/ NYU School of Medicine, Annals of Rheumatic Diseases 

About the Author
  • Experienced research scientist and technical expert with authorships on 28 peer-reviewed publications, traveler to over 60 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
JAN 08, 2019
Microbiology
JAN 08, 2019
Ebola Relative is Discovered
Bats are a vital part of the ecosystem, but they also host deadly viruses. Scientists have now discovered a new filovirus in a bat....
JAN 28, 2019
Genetics & Genomics
JAN 28, 2019
New CRISPR Enzyme is Ready for Use
The CRISPR gene editing system is usually paired with an enzyme called Cas9. Researchers have now created a new CRISPR enzyme: Cas12b....
JAN 30, 2019
Immunology
JAN 30, 2019
T Cell Stimulation for Zika Vaccine Design
Immune cells called CD4+ T cells could be important mediators of protection against the Zika virus...
FEB 20, 2019
Health & Medicine
FEB 20, 2019
Rapid Idenditfication of Microorganisms in Positive Blood Cultures Using MALDI-TOF MS
Conventional methods of identifying a positive blood culture require waiting for the blood culture broth to grow the organism and once positive, it ha...
FEB 25, 2019
Cardiology
FEB 25, 2019
Breathalyzer Testing For Chronic Illness
In the fight against disease, medicine has turned its focus from curing illness, to prevention. The prevention of disease requires studies to determine wha...
MAR 09, 2019
Videos
MAR 09, 2019
How Penicillin Works
In 1928, Alexander Fleming found a contaminated Petri dish, and from there, humanity's use of antibiotics started....
Loading Comments...