OCT 16, 2015 08:56 AM PDT

A Cure for Ebola?

WRITTEN BY: Kerry Evans
This isn’t the first time I’ve written about Ebola (and it probably won’t be the last).  Recently, a number of techniques for quickly diagnosing Ebola have been developed, and could make it to market in the (hopefully near) future.  Until now, however, there has been little progress towards vaccines or therapeutics for the virus.  Researchers at the US Army Medical Research Institute of Infectious Diseases and Gilead Sciences isolated a compound called GS-5734 that cured monkeys of Ebola virus disease (EVD).  
 
GS-5734 is a promising Ebola therapeutic.

Ebola virus causes a devastating hemorrhagic fever in humans and non-human primates, where the average survival rate is about 50%.  Clinicals symptoms include fever, headaches, vomiting, and bleeding, both internal and external.  Death often results from low blood pressure and overall fluid loss.  

GS-5734 is a nucleotide analog that inhibits the viral RNA polymerase, but does not affect host polymerases (an important consideration).  The group first tested the ability of GS-5734 to inhibit Ebola virus replication in human cell culture.  Next, they treated one group of Ebola-infected monkeys with 3 mg/kg of GS-5734, but only 50% of them survived.  They treated a second set of monkeys with a higher dose of the drug, 10 mg/kg, and all of the monkeys survived.  Clinical symptoms of EVD such as excessive bleeding were also reduced.  Although viral load was significantly decreased, it does not appear that the monkeys were “cured” of the virus.

GS-5734 was also effective against other Filoviruses such as Marburg, indicating it could serve as a broad-spectrum anti-viral.  However, the fact that Ebola virus was still detectable in the “cured” monkeys leaves me only cautiously optimistic.      

Check out the following video for information on Ebola gene-silencing technology being developed in Canada by Tekmira.  
 

Sources: ID Week 2015, Medical News Today, Genome Web, Wikipedia
 
About the Author
  • Kerry received a doctorate in microbiology from the University of Arkansas for Medical Sciences.
You May Also Like
MAY 17, 2018
Microbiology
MAY 17, 2018
Increased Concern as Ebola Outbreak Spreads to a City
Along with partners like Médecins Sans Frontières, WHO is springing into action to try to stop the spread of the virus....
MAY 30, 2018
Microbiology
MAY 30, 2018
'Innoculating' Newborns with Vaginal Fluids Found to be Unsafe
A lack of exposure to the vaginal canal does not account for the increased risk of later health problems for those born by C-section, researchers say....
JUN 22, 2018
Microbiology
JUN 22, 2018
Antiviral Compound Found in the Human Body
The human body can make a compound with a special power to fight viruses - an enzyme called viperin....
JUN 25, 2018
Microbiology
JUN 25, 2018
Gut Microbes Linked to Development of Liver Disease
The bacteria that live in our gut release compounds that might act as biomarkers, and may be a part of disease development....
AUG 02, 2018
Immunology
AUG 02, 2018
Chronic Infections Outsmart the Immune System
Chronic parasitic infection shown to take advantage of a mechanism to sustain infection and induce death of white blood cells essential to immune response....
AUG 05, 2018
Microbiology
AUG 05, 2018
The War Beneath Our Feet
The bacteria living in the soils of Earth seem locked in battle with the fungi there....
Loading Comments...